Antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract ofLaportea ovalifolia(Urticaceae), measured in rats with alloxan-induced diabetes

Abstract

A decoction of the leaves of Laportea ovalifolia is widely used in Cameroon for the treatment of several illnesses, including diabetes mellitus. The antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of the aerial parts of L. ovalifolia have now been investigated, in normal rats and rats with diabetes induced by the intraperitoneal injection of alloxan (at 150 mg/kg bodyweight). In the diabetic rats, 2 weeks of daily, intragastric treatment with the L. ovalifolia extract not only produced a significant reduction in the fasting serum glucose concentrations but also lowered the serum concentrations of total cholesterol, triglycerides, and low-density-lipoprotein cholesterol, lowered the ratio of total cholesterol to high-density-lipoprotein (HDL) cholesterol, and increased the serum concentration of HDL cholesterol. At least in rats with alloxan-induced diabetes, the methanol/methylene-chloride extract of L. ovalifolia therefore appears to possess antidiabetic and hypolipidaemic properties.

Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon

“…Leaves of Eremomastax speciosa Hochst, are used as anti-diarrheal [22], [23]. Leaves of Cassia alata are used against yellow fever or malaria, and as anti asthmatics, or anti diabetics [24], [25], [26].…”

Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines

“…Chew (Urticaceae); 34812/HNC Antihelmintic , treatment of headache, syphilitic yaws, fever, gonorrhea , rheumatism, menopausal disorder, antidote, asthma, hypertension, stomachage, diarrhea, wounds [ 60 ] Whole plant (8.82) Vanilic acid, gallic acid, ferulic acid, (6)-gingerol, capsaicin, rosemamic acid, tannic acid, p-coumaric acid, caffeic acid, scopoletin, catechin, resveratrol, genistein, apigenin, kaempherol, epicatechin, epigallocathechin, ellagic acid, myricitin acid, quercetin- 3, 7, 4-trimethyl ether, quercetin–3,7,3′,4′-trimethyl ether, artemetin, kaempferol–arabinoside, quercitrin, isoquercitrin, naringin, rutin, hesperidin, limonene, α-pinene, β-pinene, cis-ocimene, myrcene, citronellol, neryl acetate, malvidine, lycopene, carotene, lutein, hispogenin, diosgenin, neochlorogenin, hecogenin, [ 61 , 62 ] Antimicrobial effect of crude extract against; K, Ec, Sa, Bs, St, Pa, Ca, [ 61 , 63 ] Ec , Pa, Kp, Ea , Ps [ 42 ] Laportea ovalifolia (Schum.) Chew (Urticaceae) 44306/HNC Treatment of headache, internal ulcers , diabetes , bronchitis and wired [ 64 , 65 ] Leaves (12.13) and roots (6.17) Laportoside A and laportomide A [ 66 ] Crude extract of leaves: antidiabetic and hypolipidaemic effects [ 65 ], and crude extract against Ec , Kp, Pa, Ea , Ps [ 36 ] Pennisetum purpureum Schumach. (Poaceae); 12525/SRF/Cam Diuretic, antivenomous, treatment of measles , wound healing [ 67 ] Whole plant (8.82) Alkaloids, polyphenols, flavonoids, tannins, triterpenes, sterols ans saponins [ 42 ] Antimicrobial effect of EO: Ec, Pa [ 67 ] and crude extract against Ec , Kp, Pa, Ea , Ps [ 42 ] Spathodea campanulata P. Beauv.…”

Pilea umbrosa ameliorate CCl4 induced hepatic injuries by regulating endoplasmic reticulum stress, pro-inflammatory and fibrosis genes in rat

“…Compounds with antioxidant aptitude related to the prevention and treatment of oxidative damage induced by intracellular ROS level have been studied. Various taxa within the Urticaceae family have been explored for its medical potential against a wide array of diseases including cardiovascular, inflammatory, metabolic and respiratory disorders [ 15 – 17 ]. Among them some well-known plants such as Elatostema umbellatum , Pilea microphylla and Urtica dioica owing phenolic contents have been documented with antioxidant properties [ 18 ].…”