Antidiabetic and Hypolipidemic Effect of Salacia Oblonga in Streptozotocin Induced Diabetic Rats

Abstract

Objectives: The present study was conducted to evaluate the effect of a standardized hydroalcoholic root extract of Sala¬cia oblonga (SOE) on the Random Blood Glucose (RBG) levels, serum insulin, glycated haemoglobin (HbA1c) and the serum lipid profile in long standing, experimentally induced Diabetes Mellitus (DM) with glibenclamide (Glb) as the standard. Materials and Methods:Streptozotocin (STZ) induced, diabetic, Wistar rats of either sex were treated with two oral doses of SOE, 100 and 50mg/kg body wt /day, for a period of 16 weeks. The RBG was estimated at day-1 and at the end of the 16 weeks by using a glucometer. The fasting serum insulin was determined by an ELISA technique. The plasma HbA1c was evaluated by a Turbidimetric Inhibition Immunoassay (TINIA) and the lipid profile was estimated enzymatically.Results and Analysis: A 45% decrease in the RBG was seen after the treatment with the higher dose of SOE, whereas a 44% decrease was observed with the lower dose as com¬pared to the diabetic control. Serum insulin was significantly increased (P<0.05) in all the treated groups as compared to the diabetic control. Plasma HbA1c was significantly decreased (P<0.05). The serum Triacyl Glycerol (TG) levels were signifi¬cantly decreased (P<0.05) in the treated rats as compared to the diabetic control. A significant increase in HDL-cholesterol (P<0.05) in the diabetic rats as a result of the 100mg/kg SOE treatment was a remarkable finding.Conclusion: SOE improves the glycaemic parameters in diabetic rats after a prolonged treatment. The serum TG levels were normalized on treatment. A higher dose of the extract could not alter the parameters significantly, except for HDL-C.

Antidiabetic and Antilipidemic Activity of Root Extracts of Salacia oblonga against Streptozotocin-Induced Diabetes in Wistar Rats

“…The decrease was similar to that seen in rats treated with the standard control (acarbose). Previous studies on S. oblonga root extracts reported a decrease in total cholesterol and triglyceride levels, and our results are in agreement with these reports [26,27]. Thus, S. oblonga root is considered a good source of antidiabetic and antilipidemic agents, and these compounds are free from side effects [28].…”

“…The rats were fed 250 mg/kg bw of extracts each day, and the extracts lowered their blood glucose levels. Bhat et al [27] carried out antidiabetic studies on albino Wistar rats using S. oblonga root extracts at concentrations of 50, 100, and 500 mg/kg bw and observed increased insulin and decreased Hb1Ac levels. Kushwaha et al carried out antidiabetic studies using hydroalcoholic root extracts of S. oblonga and reported similar effects in rats [26].…”

Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

“…Hence, we measured the lipid profile in the serum (total, LDL, non-HDL, and HDL cholesterol and triglycerides) and free fatty acid along with the LDL to HDL ratio and our results suggest prominent hypolipidemic effect for G-400. This effect was the consequence of the synergic effect of G-400 constituents as evident from early study of S. oblonga (Bhat et al, 2012), G. sylvestre (Daisy et al, 2009), T. cordifolia (Stanely Mainzen Prince andMenon, 2003), E. officinalis (Augusti et al, 2001) and C. longa (Babu and Srinivasan, 1997).…”

Anti‐diabetic and Anti‐hyperlipidemic Effects and Safety ofSalacia reticulataand Related Species

“…The extract resulted in significant reductions in serum cholesterol and serum triglycerides. Bhat et al (2012) not only examined the antidiabetic effects of a hydroalcoholic extract of S. olbonga in streptozotocin-diabetic rats, but also the antihyperlipidemic effects. The rats were treated with 50 or 100 mg/kg of the extract for 16 weeks.…”

“…A hydroalcoholic extract of S. oblonga was administered to streptozotocin‐diabetic Wistar rats for 16 weeks at doses of 50 and 100 mg/kg (Bhat et al, ). Both doses significantly decreased random blood glucose levels (approximately 45%) as well as HbA1c, while increasing serum insulin levels.…”