Antidiabetic and Lipid‐Lowering Effects of the Polyphenol Extracts from the Leaves of Clausena lansium (Lour.) Skeels on Streptozotocin‐Induced Type 2 Diabetic Rats

Abstract

Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. This study analyzed polyphenol compounds in polyphenol extracts of the leaves C. lansium (lour.) Skeels (PEL) and investigated the protective effect of PEL against hyperglycemia and hyperlipidemia in T2DM rats. The result showed that PEL is composed mainly of gallic acid, chlorogenic acid, coffee acid, ferulic acid, and rutin. PEL could obviously relieve some symptoms of T2DM rats, including emaciation, hyperhidrosis, polyphagia, diuresis, liver swelling, kidney, and pancreas hypertrophy, as well as reduce fasting blood glucose. Moreover, the supplementation of PEL significantly ameliorated lipids disorder and protected liver in T2DM rats, including fat accumulation, improvement of lipid distribution and hepatocyte protection. These results indicate that the Oral of PEL have potential effects of against hyperglycemia and hyperlipidemia in diabetic disorders.Keywords: antidiabetic, lipid-lowering, liver protection, polyphenolPractical Application: The leaves Clausena lansium (lour.) Skeels is rich in polyphenol and other ingredients. In this research, the preliminary study shows that PEL can reduce fasting blood glucose and improve lipids disorder in rats, which will bring to diabetic patients a way to improve the disease and enhance the quality of life. The PEL therefore can be used for the production of pharmaceutical raw materials and the design of novel functional foods by simple conversion.

Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways

“…Flavonoids (about 3% in total extract) containing quercetin and kaemferol as the parent nucleus are main active components in Loquat Leaf [ 24 , 30 ]. These flavonoids not only have benefits on glucose metabolism, lipid metabolism, and NAFLD, but also exhibit anti-oxidative activity [ 23 , 24 , 25 , 26 ]. In this study, after enrichment and purification, six flavonoids were identified, and the content of TF in Loquat Leaf is 83.2 ± 2.7%.…”

“…Phytochemical studies indicate that flavonoids are a member of the main chemical components of Loquat Leaf, and most of them contain quercetin and kaemferol as the parent nucleus, such as rutin (quercetin-3- O -rutinoside), kaemferol-3- O -glucoside, and so on [ 24 ]. These flavonoids are known as powerful polyphenols and antioxidants, and they also have potent effects on metabolic syndrome, such as hyperglycemia, hyperlipidemia [ 24 , 25 ], and anti-NAFLD activities [ 26 ]. In our previous study, we demonstrated that total flavonoids (TF) isolated from Loquat Leaf displayed a beneficial effect on glucose metabolism disorder [ 24 ].…”

Screening of Musa balbisiana Colla. seeds for antidiabetic properties and isolation of apiforol, a potential lead, with antidiabetic activity

“…Currently, the hypoglycaemic properties of several medicinal plants are being investigated and this promises a great future in the development of new antidiabetic drugs. Our research mainly focuses on the identification of secondary metabolites that can play dual roles, as functional foods as well as drug candidates . Though M. balbisiana is one of the most important drupes in every part of the world, there is little information on its hypoglycaemic properties.…”

“…Primary research on various organisms in nature could reveal unexpected insights into the development of new pharmaceutical possibilities of more immediate use with fewer side effects . Also, the consumption of natural compounds is known to lead to fewer side effects compared to synthetic derivatives . The on‐going research in our laboratory focuses on the identification of compounds that hove both nutrition and drug applications .…”

A comparative UPLC‐Q‐Orbitrap‐MS untargeted metabolomics investigation of different parts of Clausena lansium (Lour.) Skeels

“…As an edible and medicinal fruit (Yang, Chen, & Huang, 1988), the bioactivities of the leaves, stem barks, seeds, and fruits of wampee have been investigated recently. For instance, the polyphenol extracts from the leaves of wampee were proven to have antidiabetic and lipid‐lowering effects on streptozotocin‐induced type 2 diabetic rats (Kong, Su, Guo, Zeng, & Bi, 2018). Chang, Lu, et al (2018)) and Chang, Ye, et al (2018) also investigated the polyphenolics profile and antioxidant activity of wampee leaves during the development process.…”