BACKGROUND: 'Phytonutrients' have been reported to exert an incredible impact on the healthcare system and offer medical benefits including the prevention or treatment of lifestyle-associated diseases. We chose one of the most common and important plant families, Musaceae, for our present study and explored its antidiabetic potential. RESULTS: Seeds of the edible fruits of Musa balbisianaColla. were investigated for their antidiabetic potential. After estimating the proximate composition, the seeds were extracted with various solvents and evaluated for antidiabetic potential in terms of the inhibition of digestive enzymes, antiglycation activity and in vitro glucose uptake. The acetone extract demonstrated the highest inhibition of -amylase and -glucosidase enzymes with IC 50 values of 36.67 ± 0.367 and 100.61 ± 0.707 g mL -1 , respectively. The extract also exhibited significant glycation inhibition with an IC 50 value of 86.48 ± 0.751 g mL -1 . Furthermore, a major phytochemical, apiforol, was isolated from the acetone extract for the first time, which demonstrated promising -glucosidase inhibition (IC 50 = 48.25 ± 0.255 mol L -1 ), antiglycation property (IC 50 = 114.23 ± 0.567 mol L -1 ) and enhanced glucose uptake in L6 myoblasts. In molecular docking studies, apiforol efficiently bonded to the active sites of -glucosidase enzyme 3A4A. CONCLUSIONS:As dietary intervention is one of the effective strategies for addressing diabetes, special attention is always given to natural food bio-actives or agro-products for better human health. The results of our study suggest that Musa balbisiana has significant potential as an ingredient in health food formulations by reducing postprandial hyperglycaemia.

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The remarkable α-glucosidase inhibition exhibited by the acetone extract of the rhizome of Ampelocissus indica (L.) and stem bark of Vateria indica Linn. (IC50 23.2 and 1.47 μg mL−1) encouraged us to isolate the phytochemicals from these plants.