Antidiabetic, Antihyperlipidemic, Antioxidant Property of Cordia obliqua on Streptozotocin Induced Diabetic Rats

Prakash, R; Ramadoss, Dhivya; Muthulingam, Priyadarshini; Nedunchezhian, Ramya; Krishnamoorthy, Karthick

doi:10.5530/jyp.2017.9.64

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…In diabetic rats, a marked increase in Serum TG, LDL and VLDL levels and a decrease in HDL level were observed. These observations could be supported with reports documented earlier [63][64][65] . In this study, sample extracts have shown lowering of TG, TCH, LDL and VLDL levels and increase in HDL level compared to the control group.…”

Section: Normal Diabetic Control Glibenclamidesupporting

confidence: 93%

Untitled

2019

IJPSR

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and NorthEastern parts of India. The leaves have been traditionally used in the treatment of diabetes and urinary disorders. The leaves were also known to possess potent antioxidant activity. Objective: Aim of the study was to investigate the in-vitro and in-vivo anti-diabetic activity of different extracts of leaves of Actinodaphane hookeri. Materials and Methods: The leaves of Actinodaphane hookeri were extracted successively with petroleum ether (AHP), chloroform (AHC), methanol (AHM) and water (AHA). Also, the leaves were extracted separately with alcohol (AHT). Extracts were subjected to phytochemical investigation and evaluated for its in-vitro anti-diabetic activity by α-glucosidase inhibitory activity, and in-vivo anti-diabetic activity was carried out in STZ-induced diabetic rats at two dose levels viz. 300 and 500 mg/kg doses for 21 days. Results: Phytochemical screening showed the presence of sterols, triterpenes, alkaloids, flavonoids, tannins, lactones and mucilages. The in-vitro αglucosidase inhibitory activity was highest in AHC with an IC 50 value of 309.04 ± 0.02 μg/ml and lowest in AHA with an IC 50 value of 812.86 ± 0.03 μg/ml. Significant decrease in blood sugar, gain in body weight, decrease in TCH, TG, LDL and VLDL and increase in HDL levels were observed. Potent activity was observed in AHC followed by AHP, AHT, AHM and AHA. Histopathological investigation showed pancreatic β-cell protection. Conclusion: The findings suggest that Actinodaphne hookeri Meissn. leaves have potent anti-diabetic activity. INTRODUCTION: Diabetes Mellitus (DM) is known to Indians from Vedic period onwards by the name Asrava (Prameha, derived from the Sanskrit words mih sechane meaning 'watering' that means dilution of everything in the body.

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Section: Normal Diabetic Control Glibenclamidesupporting

confidence: 93%

Untitled

2019

IJPSR

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“…A phase of hypoglycemia occurs due to four-fold increase in serum insulin level, and this phase is followed by persistence hyperglycemia. 12 In recent times a new animal model of Type 2 diabetes has been suggested by combining STZ and NAD in adult rats (160-240 gm).…”

Section: Methodsmentioning

confidence: 99%

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

Dewangan¹,

Tiwari²,

Sharma³

et al. 2017

IJPER

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Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day's newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.

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“…obliqua Willd. plant extracts possess antihyperlipidemic and antioxidant properties with potential application as an oral anti-hypoglycemic agent in the treatment of diabetes (Table 5, Ramakrishnan et al, 2017). The leaves of C. obliqua Willd.…”

Section: Medicinal Propertiesmentioning

confidence: 99%

A Review of Cordia Species Found in the Caribbean: Cordia Obliqua Willd., Cordia Dichotoma G. Forst. And Cordia Collococca L

Aimey

Goldson-Barnaby

Bailey

2020

International Journal of Fruit Science

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Members of the Cordia genus possess medicinal properties. There is however limited scientific literature on species within the genus that exists in the Caribbean, namely Cordia obliqua Willd., Cordia dichotoma G. Forst. and Cordia collococca L. This paper provides an overview of these plant species based on their morphology, growth conditions, fruiting season, nutritional and medicinal properties, current processing methods as well as their potential applications in the food and pharmaceutical industries.

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Antidiabetic, Antihyperlipidemic, Antioxidant Property of Cordia obliqua on Streptozotocin Induced Diabetic Rats

Cited by 4 publications

References 25 publications

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Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

A Review of Cordia Species Found in the Caribbean: Cordia Obliqua Willd., Cordia Dichotoma G. Forst. And Cordia Collococca L

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