Antidiabetic bioactive natural products from medicinal plants

Tresina, P. S.; Selvam, M. Santhiya; Doss, A.; Mohan, Vandana

doi:10.1016/b978-0-323-91250-1.00004-5

Cited by 8 publications

(1 citation statement)

References 224 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was consistent with a report by Al-Farsi and Lee (2008), which stated that water extracts of date pits were rich in dietary fibre compared to methanol extracts (Al-Farsi and Lee, 2008). These results were in line with previously reported data that BP was a useful source of dietary fibre, making it potentially beneficial for individuals with high cholesterol levels (Niewiadomska et al, 2022;Tresina et al, 2022). Our current results confirm that T contains a high amount of dietary fibre and protein.…”

Section: Discussionsupporting

confidence: 94%

Antidiabetic effect of black pepper, turmeric, and ajwa date pulp, seed, and their mixtures as antioxidants in alloxan diabetic rats

Sarfraz,

Ullah,

Iqbal

et al. 2023

J. Anim. Feed Sci.

View full text Add to dashboard Cite

Testing natural antihyperlipidemic substances is necessary due to the increasing prevalence of diabetes mellitus, which leads to chronic hyperglycaemia and poses a significant threat to public health and well-being worldwide. The present study investigated the anti-diabetic effect of black pepper, turmeric, and ajwa date pulp + seed and their mixtures as hypolipidemic, antioxidant and protective agents on the liver and kidney by examining histological changes in alloxanised diabetic rats. Eleven groups consisting of eighteen males and eighteen females were divided into a normal control (nondiabetic), a positive control (diabetic), positive groups receiving glibenclamide (10 mg kg -1 body weight), black pepper (BP), turmeric (T), ajwa pulp (AP), ajwa seeds (AS) aqueous extracts and their various combinations. The dose of BP aqueous extract was 50 mg kg -1 body weight, while the dose of the other materials was 500 mg kg -1 body weight. The aqueous extracts were administered orally once daily for eight weeks. Our phytochemical screening detected the presence of flavonoids, tannins, saponins, steroids, and alkaloids in these extracts. The results pertaining to serum levels of glucose, lipids, glycosylated haemoglobin, and antioxidant biomarkers revealed significant improvements after administration of AS, BP + AS, and the mixture of all extracts. Moreover, histological analyses demonstrated the protective effects of these extracts. In conclusion, all tested materials, especially ajwa seeds administered alone and in combination with black pepper extract, exerted significant antihyperlipidemic and weight-stabilising effects in alloxanised diabetic rats. Therefore, these natural substances hold promise as potential herbal medicines for managing diabetes mellitus.

show abstract

Section: Discussionsupporting

confidence: 94%

Antidiabetic effect of black pepper, turmeric, and ajwa date pulp, seed, and their mixtures as antioxidants in alloxan diabetic rats

Sarfraz,

Ullah,

Iqbal

et al. 2023

J. Anim. Feed Sci.

View full text Add to dashboard Cite

show abstract

Network Pharmacology Integrated With Quantum‐Polarized Ligand Docking and Molecular Simulation Revealed the Anti‐Diabetic Potential of Curcumin

Khan,

Sayaf,

Alshammarri

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Diabetes mellitus is a chronic metabolic disorder affecting millions of people worldwide and causes serious complications such as diabetic nephropathy. Curcumin, a natural polyphenol derived from turmeric, has demonstrated antidiabetic, anti‐inflammatory, and antioxidant properties. However, the molecular mechanisms underlying curcumin's anti‐diabetic effects remain incompletely understood. This study employed network pharmacology, molecular docking, and simulation techniques to explore the potential targets, and key pathways of curcumin in the treatment of diabetes. Using SwissTarget prediction and Superpred databases, we predicted the molecular targets for curcumin, while diabetes‐associated genes were obtained from DisGeNet. We identified 60 common targets for curcumin in diabetes. Protein‐protein interaction (PPI) analysis revealed three sub‐networks and ten hub genes with AKT1, TNF‐α, EGFR, and STAT3 identified as key hub genes that could serve as potential biomarkers. Gene enrichment analysis indicated that these genes primarily regulate insulin resistance and other metabolic pathways. Quantum‐polarized ligand docking (QPLD) showed that curcumin establishes multiple hydrogen and hydrophobic interactions with the essential amino acids of these hub targets. Molecular simulation results demonstrated stable dynamic behavior, a compact structure, and variations in residue flexibility. Binding free energy calculations using MM/GBSA and MM/PBSA methods validate curcumin's strong binding to the potential targets. Total binding free energy using MM/GBSA ranged from −21.35 to −30.94 kcal/mol while MM/PBSA calculations showed total binding free energy values between −19.80 and −26.66 kcal/mol. Altogether, this study provides valuable insights into the molecular targets of curcumin in diabetes and lays the foundation for future advancements in diabetes treatment.

show abstract

Effects of Nostoc sp. inoculation on the yield and quality of a medicinal plant, Allium sativum

Uniyal,

Singh,

Singh

et al. 2024

J Appl Phycol

View full text Add to dashboard Cite

Antidiabetic bioactive natural products from medicinal plants

Cited by 8 publications

References 224 publications

Antidiabetic effect of black pepper, turmeric, and ajwa date pulp, seed, and their mixtures as antioxidants in alloxan diabetic rats

Antidiabetic effect of black pepper, turmeric, and ajwa date pulp, seed, and their mixtures as antioxidants in alloxan diabetic rats

Network Pharmacology Integrated With Quantum‐Polarized Ligand Docking and Molecular Simulation Revealed the Anti‐Diabetic Potential of Curcumin

Effects of Nostoc sp. inoculation on the yield and quality of a medicinal plant, Allium sativum

Contact Info

Product

Resources

About