Antidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats

Daradka, Haytham M.; Abas, Mohaned Mohamed; Mohammad, Mukhallad A.; Jaffar, Mohamed Mousa

doi:10.1007/s00580-014-1963-1

Cited by 48 publications

(32 citation statements)

References 35 publications

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“…Artemisia absinthium L. is an herb native of the Mediterranean region. Animal studies found that extracts from this species have anti-hyperglycaemic activity (Daradka et al, 2014) and glucosidase and lipase inhibitory activities (Ramírez et al, 2012). The compounds responsible for these effects are yet to be investigated, although they are unlikely to be artemisinin derivatives, since these compounds have not been associated with hypoglycaemia (Davis, 1997).…”

Section: Plant Species Used To Treat Diabetes and Its Sequelae In Cenmentioning

confidence: 99%

“…Hypoglycaemic effect on type 2 diabetic patients (Revilla-Monsalve et al, 2007). DM: extracts of the leaves and of the whole plant have antidiabetic and anti-hyperlipidemic activity (Bhagwat et al, 2008;Pareek et al, 2009;Petchi et al, (Daradka et al, 2014). Extract has in vitro glucosidae and lipase inhibitory activities (Ramírez et al, 2012).…”

Section: Plant Species Used To Treat Diabetes and Its Sequelae In Cenmentioning

confidence: 99%

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Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Giovannini

Howes

Edwards

2016

Journal of Ethnopharmacology

122

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This review provides an overview of the medicinal plants used to manage diabetes and its sequelae in Central America and of the current scientific knowledge that might explain their traditional use. In Central America a large number of medicinal plants are used to treat this condition and its sequelae, although relatively few species are widely used across the region. For the species used to manage diabetes, there is variation in the availability and quality of pharmacological, chemical and clinical studies to explain traditional use.

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Section: Plant Species Used To Treat Diabetes and Its Sequelae In Cenmentioning

confidence: 99%

Section: Plant Species Used To Treat Diabetes and Its Sequelae In Cenmentioning

confidence: 99%

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Giovannini

Howes

Edwards

2016

Journal of Ethnopharmacology

122

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“…Their Hypoglycemic effect was comparable with that of the usual hypoglycemic drugs repaglinide, insulin, metformin and glibenclamide. [ 7 15 19 20 ] However, as can be seen from the study of some of those species of Artemisia, such as Artemisia herba-alba have a greater potency in decreasing the serum glucose level and animals treated with this plant showed only mild visible undesirable clinical symptoms whereas the synthetic oral hypoglycemic agents can produce serious side effects. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

“…Thujone can increase free insulin-stimulated glucose transporter by activation of adenosine monophosphate-activated protein kinase. [ 20 ] A reported data about the hypoglycemic activities of flavonoids, tannins and apigenin proved that they increase insulin secretion and have insulinomimetic effect. [ 34 ] The main function of flavonoids are antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effects of artemisia species: A systematic review

Dabe

Kefale

2017

Ancient Sci Life

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Background:Over the last century, human life style and food habits have drastically changed which lead to various chronic diseases. Diabetes mellitus is one such disease which is causing serious problems to human health. Allopathic drugs are not much effective in handling the disease and its complications. Hence focus has been turned towards the traditional system of medicine. Medicinal plants play an important role in the management of diabetes mellitus.Methods:Experimental studies conducted on species of Artemisia on diabetic animal models and human published since the year 2000 until April, 2017 were reviewed. Each article was critically appraised by two independent reviewers for their methodological quality using the JBIMAStARI tool.Result:A total of 14 studies were included in this review and the blood glucose data obtained from these critically reviewed studies clearly showed that both the aqueous and alcoholic extracts of species of Artemisia produced significant hypoglycemic effects in alloxan, Streptozotocin and high fat diet induced diabetic animals and diabetic humans with different mechanisms of action as compared to standard antidiabetic medications.Discussion and Conclusion:The antidiabetic effect of single or multiple doses of aqueous and alcoholic extracts of Artemisia species was due to the active compounds of these plants and they all are effective in lessening the blood glucose level in all of those experimental studies. Despite the presence of known antidiabetic medicines in the pharmaceutical market, therapeutic remedies from these medicinal plants have been utilized with success to treat this disorder and its complications with a relatively less side effects.

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“…A previous literature search revealed information about antidiabetic and enzyme inhibition properties of thujone (6,67,68). The use of thujone for the treatment of diabetes mellitus has recently been suggested by Baddar (6).…”

Section: Free Radical Scavenging Activity (Dpph Assay)mentioning

confidence: 99%

Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Özek

2018

Journal of the Turkish Chemical Society Section A: Chemistry

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Two samples of Tanacetum praeteritum (Horwood) Heywood subsp. praeteritum (Horwood) were collected in flowering period and subjected separately to hydrodistillation to yield the essential oils (A and B). The oils were investigated for chemical composition with GC-FID and GC/MS techniques and evaluated against acetylcholinesterase and -amylase enzymes and free radicals (DPPH • and ABTS •+ ) using microtiter plate assays. Both oils were characterized with high abundance of oxygenated monoterpenes. The oils were distinguished by the main constituents, namely, camphor (37.6%), 1,8-cineole (19.5%) and terpinen-4-ol (9.3%) were found as the major constituents in the oil A, while -thujone (79.4%) and -thujone (8.5%) were detected in the oil B. The oils demonstrated significant inhibitory (80% and 60.0%) potentials on acetylcholinesterase (an IC50 of 0.74 mg/mL and an IC50 of 1.78 mg/mL, respectively) which is involved in Alzheimer's disease. With respect to antidiabetic activity, the oils demonstrated significant inhibiting potential on porcine pancreatic -amylase (an IC50 of 1.02 mg/mL and an IC50 of 0.89 mg/mL) in I2/KI assay. The oils demonstrated weak free radical scavenging activity against DPPH radicals and moderate activity (0.23 mM and 0.15 mM) against ABTS +• in TEAC assay.

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Antidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats

Cited by 48 publications

References 35 publications

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Antidiabetic effects of artemisia species: A systematic review

Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

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