Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Özek, Gülmira

doi:10.18596/jotcsa.389075

Cited by 11 publications

(5 citation statements)

References 109 publications

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“…In this sense, Özek (2018) evaluated the in vitro α-amylase inhibitory effects of T. praeteritum ssp. praeteritum aerial parts essential oils using the Caraway Somogyi iodine/potassium iodide (IKI) method and acarbose as the reference drug.…”

Section: Biological Activitiesmentioning

confidence: 99%

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Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence

et al. 2023

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Introduction: The Tanacetum genus consists of 160 accepted flowering species thriving throughout temperate regions, mainly in the Mediterranean Basin, Northern America, and southwestern and eastern Asia. Tanacetum species bear a long-standing record of use in the folk medicine of indigenous tribes and communities worldwide, along with multitudinous applications in traditional cuisines, cosmeceuticals, and agricultural fields.Methods: Up-to-date data related to traditional uses, phytochemistry, biological activities, toxicity and clinical trials of the genus Tanacetum were systematically reviewed from several online scientific engines, including PubMed, Web of Science, Scopus, SciFinder, Wiley Online, Science Direct, and Cochrane library.Results and discussion: Over the past three decades, 241 metabolites have been isolated from nearly twenty species, including phenolic acids, flavonoids, coumarins, fatty acids and alkanes, aldehydes, volatile compounds, and naphthoquinones. Some unique metabolites have also been identified, such as the ceramides tanacetamide (A-D) from T. artemisioides, pyrethrins from T. cinerariifolium, and sesquiterpene lactones from several species. However, these secondary metabolites are still poorly studied despite in vitro clues highlighting their colossal pharmacological properties, especially as hypotensive, neuroprotective, anticancer, and antimicrobial agents. Scientific studies have validated some traditional claims of the plant, such as antidiabetic, anticancer, anthelmintic, insecticide, antioxidant, and hepatoprotective activities, as well as against festering wounds, skin ulcers, urinary tract infections, and sexually transmitted diseases. Other ethnomedicinal uses for arthritis, gout, rheumatism, anemia, and as a litholytic, antivenom and diaphoretic have not yet been supported and would constitute the subject of further research.

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Section: Biological Activitiesmentioning

confidence: 99%

“…The author indicated that the essential oil displayed α-amylase inhibitory features with an IC 50 value of 0.89 ± 0.13 mg/mL compared to acarbose 0.08 mg/mL. The author attributed the inhibitory effects to the high amount of oxygenated monoterpenes in the EO ( Özek, 2018 ).…”

Section: Biological Activitiesmentioning

confidence: 99%

Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence

et al. 2023

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“…Moreover, as initially disclosed, α-glucosidase inhibition effect was measured [21]. Additionally, the α-amylase inhibition experiment was subjected by adapting the procedure used by Caraway-Somogi iodine/potassium iodide method [22].…”

Section: Enzyme Inhibition Potentialsmentioning

confidence: 99%

EXAMINATION OF THE AERIAL PARTS OF CALAMINTHA PAMPHYLICA SUBSP. DAVISII (CONTANDR. & QUÉZEL) P.H. DAVIS IN TERMS OF ANTIOXIDANT AND ENZYME INHIBITION POTENTIALS, TOGETHER WITH PHENOLIC PROFILE

Eruygur

Ayaz

2022

Ankara Ecz. Fak. Derg.

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Amaç: Tıbbi ve aromatik bitkilerden oluşan Lamiaceae familyası Türkiye'de 46 cins ve 571 tür ile temsil edilmektedir. Calamintha Miller türleri geleneksel olarak uyarıcı, spazm giderici, terletici, balgam söktürücü ve baharat olarak ve bunun yanısıra mide ve boğaz ağrılarına karşı kullanılırlar. Calamintha pamphylica subsp. davisii (Contandr. & Quézel) P.H. Davis Türkiye'ye endemik bir türdür. Şimdiye kadar, bu bitki üzerinde uçucu yağ araştırmaları dışında herhangi bir biyolojik ve fitokimyasal araştırma bildirilmemiştir. Bu çalışmanın amacı, of C. pamphylica subsp. davisii’nin antioksidan ve enzim inhibisyonu etkileri ile birlikte fitokimyasal bileşeninin değerlendirilmesini incelemektir. Gereç ve Yöntem: C. pamphylica subsp. davisii’nin methanol ve su ekstreleri üzerinde in vitro antioksidan potansiyelini (DPPH, ABTS, demir şelasyon, toplam fenol ve flavonoit içeriği) ve asetilkolinesteraz, butirilkolinesteraz, α-glukozidaz, α-amilaz ve tirozinaz gibi enzim inhibitör aktiviteleri spektrofotometrik yöntemler kullanılarak ölçülmüştür. Ekstrelerin fenolik bileşimini belirlemek için HPLC kullanılmış ve çeşitli fenolik asitler ve flavonoidlerin miktarı tespit edilmiştir. Sonuç ve Tartışma: Sonuçlarımız demir şelasyon dışındaki DPPH ve ABTS yöntemleri ile metanol ekstresinin sulu ekstreden daha fazla antioksidan aktiviteye sahip olduğunu göstermiştir. Ayrıca, methanol ekstresi, test edilen asetilkolinesteraz ve α-glukozidaz dışındaki enzimler üzerinde sulu ekstreden daha fazla inhibisyon sergilemiştir. Başlıca bulunan fenolik bileşiklerin, HPLC kullanılarak metanol ve sulu ekstrelerde sırasıyla klorojenik ve kafeik asitler olduğu gösterilmiştir. Bu sonuçlar, Türk halk hekimliğinde geleneksel kullanımları olan C. pamphylica subsp. davisii için bilimsel bir temel oluşturmaktadır.

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“…These mice have a mutation in their leptin receptor, with the subsequent development of insulin resistance and obesity which was partially corrected by the administration of lemon balm essential oil ( Chung et al, 2010 ). Five experimental models used in vitro techniques for evaluating the effect of essential oils on important enzymes from glucose metabolism like α-amylase or α-glucosidase which are involved in the release of glucydic fractions in the digestive system ( Özek, 2018 ). In these models, the administration of essential oils inhibited the two enzymes with IC50 ranging from 0.5 to 8.16 µg/ml.…”

Section: Essential Oil-bearing Plants From the Balkansmentioning

confidence: 99%

“…Also, the inhibition of α-glucosidase was demonstrated by another in vitro study investigating the essential oil from Laurus nobilis L., which showed a 90% inhibition of the enzyme (IC50 of 1.748 µg/ml), the main chemical constituent responsible for the effect being 1,8-cineole ( Sahin Basak and Candan, 2013 ). The research of Özek (2018) identified a significant inhibition of α-amylase for the essential oil from Tanacetum praeteritum subsp . praeteritum (Horw.)…”

Section: Mechanisms Of Action Of Antidiabetic and Antihyperlipidemic mentioning

confidence: 99%

Essential Oil-Bearing Plants From Balkan Peninsula: Promising Sources for New Drug Candidates for the Prevention and Treatment of Diabetes Mellitus and Dyslipidemia

et al. 2020

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Metabolic diseases like diabetes mellitus or dyslipidemia have a complex etiology characterized by the interference of genetic predisposition and environmental factors like diet or lifestyle. Over time they can cause significant vascular complications, leading to dysfunction or failure of key organs (brain, heart), with possible fatal consequences or a severe reduction of life quality. Although current authorized drugs may successfully control blood glucose or cholesterol level, their use is often associated with severe side effects, therefore the development of new drug candidates is necessary for a better management of metabolic diseases. Among potential new drug sources, aromatic plants rich in essential oils like Melissa officinalis L., Mentha x piperita L., Cuminum cyminum L. or Pistacia lentiscus L. var. chia are very promising due to their diverse chemical composition and multiple mechanisms of action. This review describes a series of recent experimental studies investigating antidiabetic and hypolipemic effects of essential oils extracted from several aromatic plant species with an ethnopharmacological relevance in the Balkan peninsula. The pharmacological models used in the studies together with the putative mechanisms of action of the main constituents are also detailed. The presented data clearly sustain a potential administration of the studied essential oils for the prevention and treatment of metabolic diseases. Further research is needed in order to ascertain the therapeutic importance of these findings.

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Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Cited by 11 publications

References 109 publications

Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence

Tanacetum species: Bridging empirical knowledge, phytochemistry, nutritional value, health benefits and clinical evidence

EXAMINATION OF THE AERIAL PARTS OF CALAMINTHA PAMPHYLICA SUBSP. DAVISII (CONTANDR. & QUÉZEL) P.H. DAVIS IN TERMS OF ANTIOXIDANT AND ENZYME INHIBITION POTENTIALS, TOGETHER WITH PHENOLIC PROFILE

Essential Oil-Bearing Plants From Balkan Peninsula: Promising Sources for New Drug Candidates for the Prevention and Treatment of Diabetes Mellitus and Dyslipidemia

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