Antidiabetic effect of compounds isolated from plants

Rm, Perez; Zavala, S Miguel; Perez, G.

doi:10.1016/s0944-7113(98)80060-3

Cited by 99 publications

(54 citation statements)

References 58 publications

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“…It is commonly recognized that certain flavonoids and triterpenoids from plant exhibit antidiabetic activity (Perez et al 1998). In previous studies, several flavonoids and triterpenoids have been isolated from H. angustifolia root (Chen et al 1994(Chen et al 2006, and some of them have been proven to have antidiabetic activity.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic activity of Helicteres angustifolia root

Cheng

Zhang

2016

Pharmaceutical Biology

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ContextThe root of Helicteres angustifolia L. (Sterculiaceae) has been used as folk herbal drug to treat cancer, bacterial infections, inflammatory, and flu in China. However, there is no report on its antidiabetic activity. Objective This study evaluates the antidiabetic activity of ethanol extract from H. angustifolia root. Materials and methods The promoting effect of H. angustifolia root ethanol extract (25, 50, and 100 mg/mL) on glucose uptake was evaluated using HepG2 cell, differentiated C2C12 myotubes, and differentiated 3T3-L1 adipocytes. The antidiabetic activity of the extract was assessed in vivo using STZ-induced diabetic rats by orally administration of the extract (200 and 400 mg/kg b.w.) once per day for 28 d. Blood glucose, TG, TC, TP, HDL-C, UA, BUN, AST, ALT, insulin, and HOMA-IR were analyzed. Results The results showed that the extract increased glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes with an IC 50 value of 79.95 and 135.96 mg/mL, respectively. And about 12%, 19%, and 10% (p 5 0.05) in HepG2 cells when compared with the control at the concentration of 25, 50, and 100 mg/mL, respectively. After 28 days' treatment with the extract, significant reduction was observed in blood glucose, HOMA-IR, TC, TG, UA, BUN, AST, and ALT levels, while the levels of TP and HDL cholesterol increased. Discussion and conclusion These results suggest that H. angustifolia root ethanol extract possess potent antidiabetic activity, which is the first report on antidiabetic activity of this plant.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic activity of Helicteres angustifolia root

Cheng

Zhang

2016

Pharmaceutical Biology

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“…In recent years, various plant extracts have been claimed to be useful for the cure of diabetes mellitus [23][24][25][26] but few of them were tested for their effects on tissues of diabetic animals. 23,27,28) Acute treatment with Aloe leaf pulp resulted in a 30% and 34% decrease in blood sugar levels of n0STZ-diabetic rats, after 2 and 3 h of administration of the extract respectively, 13) whereas chronic treatment with the same extract leads to 7% decrease in blood glucose on the 7th day of administration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Aloe vera Leaf Gel and Pulp Extracts on the Liver in Type-II Diabetic Rat Models

Can

Akev

Özsoy

et al. 2004

Biological & Pharmaceutical Bulletin

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The aim of this work was to investigate the effects of Aloe vera leaf pulp and gel extracts on the liver tissue of neonatal streptozotocin (n0STZ)-induced type-II diabetic rats. The diabetic rats were separated into four groups and each group was given the following samples by gavage, daily for 15 d: phosphate buffered saline (PBS; diabetic control), Aloe leaf pulp extract, Aloe leaf gel extract, glibenclamide. Liver tissues were examined histologically. The markers of oxidative stress: glutathione (GSH), non-enzymatic glycosylation (NEG) and lipid peroxidation (LPO), were determined in liver tissue. Biochemical parameters for liver function: serum alkaline phosphatase (ALP), and alanine transaminase (ALP) activities, were evaluated. All parameters were also determined in healthy (non diabetic) rats for comparison. In the diabetic control group, the degenerative changes in liver tissue were remarkable, while in the diabetic groups given Aloe pulp and gel extracts and glibenclamide, the damage to the liver tissue was decreased. The increase of GSH and the decrease of NEG and LPO in liver tissues with the treatment of Aloe gel extract, is consistent with the beneficial effect of Aloe. Serum ALP and ALT activities were also decreased in the groups given Aloe gel extract. It was concluded that Aloe gel extract has a protective effect comparable to glibenclamide against hepatotoxicity produced by diabetes if used in the treatment of type-II diabetes.

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“…Three basic management methods already in use include diet, exercise and medication and there is still no perfect cure for diabetes and available therapies are extremely expensive Seuring 2015). Natural sources may however provide feasible alternatives for the treatment of diabetes (Marles and Farnsworth 1995;Perez et al 1998;Coman et al 2012). Folklore medications of DM in South East (SE) Nigeria, just as in other parts of West Africa, employ local decoctions in alcohol or water.…”

Section: Introductionmentioning

confidence: 99%

Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats.

Okolo¹,

Ejere²,

Chukwuka³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: The fruit extract of Dacryodes edulis (D. edulis), the African pear or plum, a tree indigenous to the humid tropics has been used for managing wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in decoctions administered to diabetic patients. However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model. Materials and Methods: Sub-toxic doses between 400 and 1600mg/kg were orally administered sub-chronically to alloxan-induced diabetic rats for 15 days and compared to glibenclamide (2.5mg/kg). The glycaemia levels, body weights, lipid profile, blood urea, creatinine and liver enzyme levels were measured. Basic histology of the pancreatic tissue was also performed to examine the effects on the pancreas as possible mechanistic lead. Results: Oral acute dosing of D. edulis hexane extract decreased blood glucose levels, while sub-chronic treatment of the extract down-regulated significantly hyperglycaemia, total cholesterol, triglycerides, LDL-C, ALT and ALP levels. However, the HDL-C levels increased significantly. Histopathological examination of the pancreatic tissues after sub-chronic treatment showed that glibenclamide and the highest dose of the extract 1600mg/kg restored the afore-damaged pancreatic β-cell architecture. Conclusion: Our findings portend that D. edulis hexane fruit extract possesses hypoglycaemic and hypolipidaemic activities as well as restoration of the pancreatic architecture without any obvious untoward hepatic damages, suggesting that its use in the management of the diabetes may be valid.

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Antidiabetic effect of compounds isolated from plants

Cited by 99 publications

References 58 publications

Antidiabetic activity of Helicteres angustifolia root

Antidiabetic activity of Helicteres angustifolia root

Effect of Aloe vera Leaf Gel and Pulp Extracts on the Liver in Type-II Diabetic Rat Models

Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats.

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