Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats

Pandit, Rucha; Phadke, A. V.; Jagtap, Aarti

doi:10.1016/j.jep.2010.01.025

Cited by 129 publications

(72 citation statements)

References 15 publications

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“…It was administered in three doses i.e., 100 mg/ kg body weight [12,13], 200 mg/ kg body weight [13], and 400 mg/ kg body weight. Streptozotocin (STZ) was procured from Merck, KGaA, Germany.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

An Evaluation of the Preventive Role of Ficus religiosa on High Fat Diet and Low Dose Streptozotocin Induced Diabetes Mellitus in Rats

Nath¹

2016

DMD

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Section: Drugs and Chemicalsmentioning

confidence: 99%

An Evaluation of the Preventive Role of Ficus religiosa on High Fat Diet and Low Dose Streptozotocin Induced Diabetes Mellitus in Rats

Nath¹

2016

DMD

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“…A wide variety of the traditional herbal remedies are used by diabetic patients, especially in the third world countries. 5,6 Ficus religiosa is a large tree belonging to the family Moraceae. This tree is given the name of Budhidhidru or tree of wisdom by Buddhists.…”

Section: Introductionmentioning

confidence: 99%

“…8 This plant reduces the levels of serum triglyceride and total cholesterol in STZ-induced diabetic rats. 9 Dietary fibre content of foods namely, peepalbanti influenced total lipids, cholesterol, triglycerides and phospholipids of the liver to varying extents. 10 Ficus religiosa is rich in soluble fiber beta-glucan and it is contributes to lowering blood cholesterol level.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and antihyperlipidemic effect of aqueous leaves extract of Ficus Religiosa in alloxan induced diabetic rats

Pochhi¹,

2017

Asian J Med Sci

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A B S T R A C TBackground: Medicinal plants provide valuable therapeutic agents,with less adverse effects. A number of indigenous plants were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the hypoglycemic and antihyperglycemic effect of aqueous leaves extract of F. religiosa in alloxan diabetes albino rats. Aims and Objectives: Therefore, the present thesis aim is in evaluating whether the hyperglycemic condition is related with hyperlipidemia and both these conditions could be controlled by indigenous preparations. Materials and Methods: The aqueous leaves extracts of Ficus religiosa (250 mg/kg) were administered orally for 21 days, in alloxan induced diabetic rats on Glucose, Lipid profile, Lipoproteins and Lipid metabolizing enzymes. Result: The aqueous leaves extract of F. religiosa induced significant improvement in glucose, serum lipids, lipoproteins concentration and lipid metabolizing enzymes activity (Lipase, HMG CoA reductase and LCAT). Conclusion: The present study indicates that the extract of Ficus religiosa exhibits lipid lowering, maintaining lipoproteins concentration and improve the activities of lipid metabolizing enzymes in hyperglycemic rats, by initiating the release of insulin. This study confirm the possible role of indigenous medicinal plants in the treatment of Diabetes.

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“…This plant has long been used in traditional medicine for various disorders and its different parts have been used medicinally in various forms as well as in combination with other herbs. This plant has been shown to have numerous biological activities such as wound healing, antibacterial, anticonvulsant, antidiabetic, antiinflammatory and acetyl cholinesterase inhibitory activity [8][9][10][11][12][13]. The acetone extract of F. religiosa leaves has been shown to induce apoptosis in breast cancer cell lines [14].…”

Section: Introductionmentioning

confidence: 99%

An Aqueous Extract of the Leaves of Ficus religiosa Inhibits the Growth of Urinary Calcium Hydrogen Phosphate Dihydrate Crystals-An In-Vitro Study

Jayakumar¹

2017

ACIM

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Background: Ficus religiosa L (Lauraceae) has been shown to have numerous biological activities such as wound healing, antibacterial, anticonvulsant, antidiabetic and antiinflammatory. However, the effects of this plant on Calcium Hydrogen Phosphate Dihydrate (CHPD) urinary crystals remain obscured. The present study investigated the inhibitory action of an aqueous extract of the Ficus religiosa (F. religiosa) leaves on the growth of CHPD crystals.Methods: CHPD crystals were grown as a urinary type using single diffusion gel technique in silica hydro-gels. An extract (50, 75 and 100%) of the leaves of F. religiosa was added over to CHPD crystals growth for 12 days to evaluate its inhibitory effect. Thermogravimetric (TGA) and powder X-ray diffraction analyses were performed to characterize the cultured CHPD crystals.Results: A 75 and 100% aqueous extracts of the leaves of F. religiosa was significantly (P<0.05 and 0.01, respectively) reduced CHPD crystals growth and the inhibition rate was almost >50%. Whereas, a moderate inhibition (P<0.05) of CHPD crystal growth was found in 75% of aqueous leaf extracts of F. religiosa. However, 50% of aqueous leaf extracts of F. religiosa exhibit no inhibition on the CHPD crystal growth. Conclusion:These results indicate that the higher concentration of the leaf extracts of F. religiosa is highly responsible for the inhibition of CHPD crystal growth. This study may suggest that F. religiosa can be used as therapeutic agent for the treatment of urinary calculi or their prevention.

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Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats

Cited by 129 publications

References 15 publications

An Evaluation of the Preventive Role of Ficus religiosa on High Fat Diet and Low Dose Streptozotocin Induced Diabetes Mellitus in Rats

An Evaluation of the Preventive Role of Ficus religiosa on High Fat Diet and Low Dose Streptozotocin Induced Diabetes Mellitus in Rats

Hypoglycemic and antihyperlipidemic effect of aqueous leaves extract of Ficus Religiosa in alloxan induced diabetic rats

An Aqueous Extract of the Leaves of Ficus religiosa Inhibits the Growth of Urinary Calcium Hydrogen Phosphate Dihydrate Crystals-An In-Vitro Study

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