Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats

Moree, Sadiq S.; Kavishankar, G.B.; Rajesha, J.

doi:10.1016/j.phymed.2012.11.011

Cited by 55 publications

(21 citation statements)

References 41 publications

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“…The streptozotocin-induced treatment group experienced very high preprandial glucose levels exceeding 200 mg/dL and can be categorized as DM. The same is also shown in Moree et al [27]. In this study, male Wistar rats induced by streptozotocin dose 60 mg/kg increased blood glucose levels <200 mg/dL.…”

Section: Effect Of Na Alginate On Blood Glucosesupporting

confidence: 91%

Therapeutic Potential of Seaweed Polysaccharides for Diabetes Mellitus

Husni¹

2018

Seaweed Biomaterials

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Seaweed has attracted a great deal of interest as excellent sources of nutrients. Seaweeds contain polysaccharides, proteins, amino acids, lipids, peptides, minerals, and some vitamins. Polyphenols of seaweed was used as cosmetics and pharmacological as antioxidants, protection from radiation, anti-inflammatory, hypoallergenic, antibacterial, and antidiabetic. Besides that seaweed also has a high content of antioxidant that can be used to ward off free radicals that increase due to the condition of hyperglycemia in a patient with diabetes mellitus. Hence, a great deal of attention has been directed at isolation and characterization of seaweed polysaccharides because of their numerous health benefits, especially for diabetes mellitus. This paper is expected to provide information on the effect of alginate from two seaweeds on blood glucose and lipid profiles of diabetic rats.

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Section: Effect Of Na Alginate On Blood Glucosesupporting

confidence: 91%

Therapeutic Potential of Seaweed Polysaccharides for Diabetes Mellitus

Husni¹

2018

Seaweed Biomaterials

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“…Globally its incidence is considered to be about 5% of the total population [2]. The chronic hyperglycemia of DM is coupled with eternal damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels [3].…”

Section: Introductionmentioning

confidence: 99%

Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes

Ashafaq

Varshney

Khan

et al. 2014

BioMed Research International

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Oxidative stress has been implicated in pathogenesis of streptozotocin- (STZ-) induced diabetes mellitus and its complication in central nervous system (CNS). Recent studies have provided insights on antioxidants and their emergence as potential therapeutic and nutraceutical. The present study examined the hypothesis that hesperidin (HP) ameliorates oxidative stress and may be a limiting factor in the extent of CNS complication following diabetes. To test this hypothesis rats were divided into four groups: control, diabetic, diabetic-HP treated, and vehicle for HP treatment group. Diabetes mellitus was induced by a single injection of STZ (65 mg/kg body weight). Three days after STZ injection, HP was given (50 mg/kg b.wt. orally) once daily for four weeks. The results of the present investigation suggest that the significant elevated levels of oxidative stress markers were observed in STZ-treated animals, whereas significant depletion in the activity of nonenzymatic antioxidants and enzymatic antioxidants was witnessed in diabetic rat brain. Neurotoxicity biomarker activity was also altered significantly. HP treatment significantly attenuated the altered levels of oxidative stress and neurotoxicity biomarkers. Our results demonstrate that HP exhibits potent antioxidant and neuroprotective effects on the brain tissue against the diabetic oxidative damage in STZ-induced rodent model.

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“…Secoisoresinol which has highest MolDock score showed interaction with His 110. Moreover, antidiabetic effect of secoisoresinol has been shown in animal model also [38]. This clearly indicated that secoisoresinol from Pinus roxburghii can be utilized to care for diabetes.…”

Section: Discussionmentioning

confidence: 95%

Pharmacophore Modeling and Molecular Docking Studies on Pinus roxburghii as a Target for Diabetes Mellitus

Kaushik

Khokra

Rana

et al. 2014

Advances in Bioinformatics

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The present study attempts to establish a relationship between ethnopharmacological claims and bioactive constituents present in Pinus roxburghii against all possible targets for diabetes through molecular docking and to develop a pharmacophore model for the active target. The process of molecular docking involves study of different bonding modes of one ligand with active cavities of target receptors protein tyrosine phosphatase 1-beta (PTP-1β), dipeptidyl peptidase-IV (DPP-IV), aldose reductase (AR), and insulin receptor (IR) with help of docking software Molegro virtual docker (MVD). From the results of docking score values on different receptors for antidiabetic activity, it is observed that constituents, namely, secoisoresinol, pinoresinol, and cedeodarin, showed the best docking results on almost all the receptors, while the most significant results were observed on AR. Then, LigandScout was applied to develop a pharmacophore model for active target. LigandScout revealed that 2 hydrogen bond donors pointing towards Tyr 48 and His 110 are a major requirement of the pharmacophore generated. In our molecular docking studies, the active constituent, secoisoresinol, has also shown hydrogen bonding with His 110 residue which is a part of the pharmacophore. The docking results have given better insights into the development of better aldose reductase inhibitor so as to treat diabetes related secondary complications.

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Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats

Cited by 55 publications

References 41 publications

Therapeutic Potential of Seaweed Polysaccharides for Diabetes Mellitus

Therapeutic Potential of Seaweed Polysaccharides for Diabetes Mellitus

Neuromodulatory Effects of Hesperidin in Mitigating Oxidative Stress in Streptozotocin Induced Diabetes

Pharmacophore Modeling and Molecular Docking Studies on Pinus roxburghii as a Target for Diabetes Mellitus

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