Antidiabetic Effect of Tecomine and Tecostanine

Hammouda, Y.; Amer, M. Samir

doi:10.1002/jps.2600551228

Cited by 54 publications

(20 citation statements)

References 2 publications

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“…T. stans growing in Egypt has two alkaloids called tecomine-1 and tecostanine-2 as the main active compounds in T. stans (Hammouda et al, 1964;Hammouda and Amer, 1996). Recently, Alonso-Castro et al (2010) reported that T. stans extracts contained more phenolics, flavonoids and alkaloids than other studied species and the chemical characterization of T. stans extra resulted in 12±2.1 GAEg/kg of phenolic compounds, 1.2±0.1 quercetin g/kg of flavonoids and 20.5±3.4 atropine g/kg of alkaloids.…”

Section: Yield and Phytochemical Analysismentioning

confidence: 99%

Antioxidant and antibacterial activities of leaves and branches extracts of Tecoma stans (L.) Juss. ex Kunth against nine species of pathogenic bacteria

Salem¹,

Gohar²,

Camacho³

et al. 2013

Afr. J. Microbiol. Res.

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Tecoma stans of the Bignoniaceae family, is an important medicinal plant. Different extracts of the leaves and branches of T. stans were evaluated as antibacterial potential against the growth of some human bacterial strains using the disc diffusion and minimum inhibitory concentration (MIC) methods as well as the antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Total phenolic and total flavonoid contents were determined. The different extracts of T. stans were obtained by successive solvent extraction with methanol and its fractions; ethyl acetate (EtOAc), chloroform (CHCl 3 ), n-butanol and aqueous. The methanol, EtOAc and CHCl 3 extracts of T. stans showed significant effect against the tested bacteria (Bacillus subtilis, Micrococcus luteus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Serratia marcescens, Salmonella typhi, Proteus vulgaris and Pseudomonas aeruginosa). The methanol extract of the leaves exhibited the highest amount of total phenolics (50.3±3 mg gallic acid equivalents/g extract) and flavonoids (40.66±5.03 mg catechin equivalents/g extract). The EtOAc fraction of leaves and branches extracts showed the highest total antioxidant activity (%) with 83.4±0.31 and 82.06±0.54%, respectively followed by CHCl 3 fraction of leaves extracts (79.17±0.20%). These findings provide scientific evidence to support traditional medicinal uses of T. stans and indicate a promising potential for the development of an antibacterial and antioxidant agent from T. stans trees.

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Section: Yield and Phytochemical Analysismentioning

confidence: 99%

Antioxidant and antibacterial activities of leaves and branches extracts of Tecoma stans (L.) Juss. ex Kunth against nine species of pathogenic bacteria

Salem¹,

Gohar²,

Camacho³

et al. 2013

Afr. J. Microbiol. Res.

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“…Et 2 O (5 ml); CH 3 (1H, s). Crystals suitable for X-ray analysis were grown from a methanolic solution.…”

Section: B-hydroxyskitanthine Methiodide (3a)mentioning

confidence: 99%

“…In fact, Tecomine 1 and Tecostanine 2, isolated from Tecoma stans growing in Egypt, were shown to produce a marked reductions in the blood sugar of fasting rabbits (normal or alloxantreated animals) both orally or i.v. ; the mechanism of action of these substances was not elucidated, but they showed to be inactive in the absence of pancreas [3,4]. Recently, Tecostanine 2 was shown to be inactive as hypoglycemic agent in normoglycemic and hyperglycemic rats [5].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Pharmacological Activities of the Tecoma Stans Alkaloids.

et al. 2004

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Tecoma stans is a plant traditionally used in Mexico for the control of diabetes. Amongst the alkaloids isolated from the plant harvested in Egypt, Tecomine was shown to be one of the compounds responsible for the hypoglycemic action. Given the interest in substances able to treat type II diabetes, we isolated the main alkaloids present in the plant growing in Egypt and Brazil and tested them in vivo on db/db mice. Contrary to previous literature reports on different animal models, Tecomine was unable to modify glycemia; the only effect seen being a decrease in plasma cholesterol levels. On the contrary, when tested in vitro on glucose uptake in white adipocytes, the compound showed a marked effect. The two other alkaloids isolated, namely 5b-Hydroxyskitanthine, early called Base C, and Boschniakine were inactive both in vivo and in vitro assays.

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“…The plant leaf extract reduces blood sugar of fasting rabbits (Hammouda, Rashid & Amer 1964). The plant contains monoterpene alkaloids and two of them (tecomine and tecostanine) are responsible for the hypoglycaemic activity of the plant (Hammouda & Amer 1966). No information in the literature was found on the antifungal activity of the plant, therefore leaving scope for this study to provide information regarding possible antifungal uses.…”

Section: Introductionmentioning

confidence: 99%

<i>Tecoma stans</i> (Bignoniaceae), leaf extracts, fractions and isolated compound have promising activity against fungal phytopathogens

Meela

Mdee

Eloff

2017

Suid-Afrikaanse Tydskr Natuurwetenskap Tegnol

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Plant pathogenic fungi are a major cause of reduced plant production and post-harvest losses of plant produce. The control of these fungi by some synthetic fungicides is complicated by human and environmental toxicity, the development of resistance by some fungi and high costs, thus prompting the investigation of other means of fungal control. Plant secondary metabolites have a good potential as antifungal agents. The aim of this study is to investigate the potential use of Tecoma stans as a plant-derived fungicide by determining the antifungal activity of extracts, isolating the bioactive compound and testing the toxicity of both the extract and the isolated compound. In bioassay-guided fractionation of the leaves of the Tecoma stans dichloromethane (DCM) extract contained one major compound that was isolated and characterised as oleanolic acid. The DCM extract and oleanolic acid were active against 10 tested plant fungal pathogens (Aspergillus niger, Aspergillus parasiticus, Collectotrichum gloeosporoides, Fusarium oxysporium, Penicillum expansum, Penicillum janthinellum, Pythium ultimum, Phytophthora nicotiana, Trichoderma harzianum and Rhizoctonia solani) with an average minimal inhibitory concentration of 130 μg/mL. The DCM extract and oleanolic acid were toxic to Vero cells with an LC50 of 0.413 mg/mL and 0.129 mg/mL respectively, when compared with berberine, a toxic compound with LC50 of 15.48 µg/mL. Oleanolic acid was more toxic than the crude extract, supporting the potential use of plant extracts for controlling plant fungal pathogens. The selectivity indices of 20 with several fungi indicated that extracts could possibly be used under controlled conditions against infections of certain fungal pathogens, even on edible plants. The large quantities available of this invasive plant species could lead to a commercially useful product in controlling plant fungal pathogens. Research correlation: This article is the translated version, made available to provide access to a larger readership, of which the original English article is available here: https://doi. org/10.4102/satnt.v36i1.1496

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Antidiabetic Effect of Tecomine and Tecostanine

Cited by 54 publications

References 2 publications

Antioxidant and antibacterial activities of leaves and branches extracts of Tecoma stans (L.) Juss. ex Kunth against nine species of pathogenic bacteria

Antioxidant and antibacterial activities of leaves and branches extracts of Tecoma stans (L.) Juss. ex Kunth against nine species of pathogenic bacteria

Isolation and Pharmacological Activities of the Tecoma Stans Alkaloids.

<i>Tecoma stans</i> (Bignoniaceae), leaf extracts, fractions and isolated compound have promising activity against fungal phytopathogens

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