Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats

Lu, Jianmei; Wang, Yanfang; Yan, Hongli; Lin, Pei; Gu, Wen; Yu, Jianhua

doi:10.1016/j.jep.2015.12.057

Cited by 71 publications

(37 citation statements)

References 31 publications

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“…A number of anti-diabetic drugs including biguanides and thiazolidinedione have lost effectiveness against this disease, due to drug resistance and which leads to serious side effects, such as heart failure or liver disease, cardiovascular risk, hepatotoxicity, hypoglycemia, weight gain, lactic acidosis, acute pancreatitis and gastrointestinal adverse effects, and hence the need for searching safe antidiabetic medicines from natural plant sources seems to be promising 6 . During the recent decades, the bioactive compounds extracted from bio-resources like microorganisms, terrestrial and marine plants were tried against diabetes 7 .…”

Section: Introductionmentioning

confidence: 99%

Gc-MS Profiling, Chemical Characterization, Antioxidant, Α-Amylase and Α-Glucosidase Inhibition of Selected Seaweeds From Southeast Coast of India: An in Vitro Approach

Deepak

Sowmiya²,

Kamaraj

et al. 2018

J. Drug Delivery Ther.

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The present study focuses on in vitro antioxidant and enzyme inhibitory activity of three different solvent extracts (Methanol, Ethyl acetate and Hexane) of 3 different seaweeds viz: Sargassum wightii, Caulerpa racemosa, and Acanthophora spicifera. The preliminary phytochemical analyses of the seaweed extracts have revealed the presence of various phytochemicals. The antioxidant activities of the seaweed extracts have shown the scavenging effect. Among the extracts, SWEA, SWME and SWHE have exerted effective antioxidant activity with the IC 50 values (µg/mL) of: 32.86, 130.1 and 212.8, respectively. And similar trend of α-amylase and α-glucosidase activity/inhibitory property by seaweeds have been recorded. Hence, the ethyl acetate extract of S. wightii was subjected to gas chromatography. All the seaweed extracts were characterized through HPLC and FTIR analyses. The GC-MS analysis of ethyl acetate extract of S. wightii showed the presence of a bioactive compound, Heptadecanoic acid that might be have been the reason for the recorded inhibitory activity.

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Section: Introductionmentioning

confidence: 99%

Gc-MS Profiling, Chemical Characterization, Antioxidant, Α-Amylase and Α-Glucosidase Inhibition of Selected Seaweeds From Southeast Coast of India: An in Vitro Approach

Deepak

Sowmiya²,

Kamaraj

et al. 2018

J. Drug Delivery Ther.

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“…Anticipated pharma activity includes anti-lipid peroxidation of plasma lipoprotein with the concomitant effect as a reduction in the risk of atherosclerosis [5], anti-diabetic activities from steroidal saponins of the Polygonatum kingianum in origin [32], and in the treatment of other ailments of human metabolic disorder and infectious agents [33]. The phyto-constituent analyses of the extracts of V. doniana and P. macrophylla indicated varying concentrations of tannins, flavonoids, anthroquinones, and alkaloids.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Saponin Extract from Vitex doniana and Pentaclethra macrophylla for Antibacterial Activity

et al. 2016

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Saponins are pharmacologically active compounds that have been shown to ameliorate abnormal physiological processes and be aptly applied in folklore for the treatment of maladies occasioned by infectious agents. Consequently, saponins from Vitex doniana and Pentaclethra macrophylla were evaluated for antibacterial properties, as these herbs are used in folk medicine. Dried pulverized plant materials were defatted, and solvents with varying polarity were applied at varying ratios for the extraction of saponins. Phyto-chemistry was in accordance with standard methods, while an antibacterial assay was made through the agar well diffusion and micro broth dilution techniques. Phytochemical quantitation showed high concentrations of tannins, 231˘0.6 CE/g, and saponins, 58% from V. doniana. Similarly, P. macrophylla stem bark extract also showed high concentrations of tannins, 309˘2.42 CE/g, alkaloids, 71%˘0.5%, and saponins, 87%˘3.4%. The ethanol extracts of V. doniana inhibited the growth of Staphylococcus aureus (ATCC 11775) and a clinical strain with inhibition zone ranges of 15.5˘2.12 to 7.0˘0.0 (mm) against leaf extracts and 20.0˘1.41 to 7.0˘0.0 (mm) against stem bark extracts. Conversely, saponin extract from V. doniana showed a broad spectrum of activity, as it inhibited both Gram-negative and -positive test strains, E. coli clinical strain (20.0˘1.41 mm), P. aeruginosa clinical strain (18.5˘0.71 mm), E. coli ATCC 11775 (17.0˘0 mm), and S. aureus clinical strain (13.0˘1.41 mm). However, a broad spectrum was similarly achieved with P. macrophylla extracts, as all test bacteria genus was susceptible. Saponin fractions showed a high potency and broad spectrum antibacterial activity and thus a validation of the folklore applications and the potential for use as a drug or drug scaffold.

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“…The low-, moderate-, and high-dose groups were intragastrically given of BE (200, 400, and 600 mg/kg b.w., respectively) daily for 28 days, and intraperitoneal (i. p.) injection of 1 % STZ citric acid buffer (0.1 mol/L, pH 4.5) on days 2 and 6, at 60 min after administration of BE. [30] The normal control group was fed standard rat chow diet, and the other five groups were given a high-fat/high-sugar diet for 28 days. All the mice received water ad libitum.…”

Section: Experimental Designmentioning

confidence: 99%

Anti‐Lipid Peroxidation, α‐Glucosidase and α‐Amylase Inhibitory Effects of the Extract of Capitula of Coreopsis tinctoriaNutt. and Protection Effects on High‐Fat/High‐Sugar and Streptozotocin‐Induced Type 2 Diabetes in Mice

Zhang

Luo

et al. 2019

Chemistry & Biodiversity

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Coreopsis tinctoria capitula (CTC) of the Compositae family has been used traditionally to treat various diseases in China, particularly type 2 diabetes mellitus (T2DM). This study evaluated the anti-lipid peroxidation, α-glucosidase and α-amylase inhibitory effects of CTC extracts, and analyzed its chemical composition by HPLC. Moreover, the antioxidant activity and protection effects of CTC extracts were investigated on high-fat/highsugar and streptozotocin-induced T2DM mice. In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti-lipid peroxidation (IC 50 : BHA > BE or EAE > ascorbic acid, p < 0.05) and α-glucosidase inhibitory activity (IC 50 : BE > EAE, p < 0.05). In vivo, the BE at the dose of 600 mg/kg was intragastrically given to T2DM mice, which exhibited a certain extent of repair and improvement of the levels of CAT, GSH, GSH-P X , SOD, as well as plasma biomarkers, compared with those in the model group (p < 0.05). These results demonstrated that CTC extracts have a positive effect to treat T2DM and it can be used for the treatment of T2DM in the future.

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Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats

Cited by 71 publications

References 31 publications

Gc-MS Profiling, Chemical Characterization, Antioxidant, Α-Amylase and Α-Glucosidase Inhibition of Selected Seaweeds From Southeast Coast of India: An in Vitro Approach

Gc-MS Profiling, Chemical Characterization, Antioxidant, Α-Amylase and Α-Glucosidase Inhibition of Selected Seaweeds From Southeast Coast of India: An in Vitro Approach

Evaluation of Saponin Extract from Vitex doniana and Pentaclethra macrophylla for Antibacterial Activity

Anti‐Lipid Peroxidation, α‐Glucosidase and α‐Amylase Inhibitory Effects of the Extract of Capitula of Coreopsis tinctoriaNutt. and Protection Effects on High‐Fat/High‐Sugar and Streptozotocin‐Induced Type 2 Diabetes in Mice

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