Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of aloe components

Beppu, Hidehiko; Shimpo, Kan; Chihara, Takeshi; Kaneko, Takaaki; Tamai, Ikuko; Yamaji, Sachiyo; Ozaki, Sayaka; Kuzuya, Hiroshi; Sonoda, Shigeru

doi:10.1016/j.jep.2005.10.034

Cited by 75 publications

(57 citation statements)

References 28 publications

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“…Many of the medical effects, such as immuno-stimulation, promotion of wound healing, and antibiotic protection, as well as anti-inflammatory, hypoglycemic, and anti-oxidant effects of Aloe leaves have been investigated (8). In particular, the anti-diabetic effects of Aloe vera gel have been well studied both in humans (11,12) and streptozotocin-induced animal diabetes models (13,14,34).…”

Section: Discussionmentioning

confidence: 99%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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SummaryThe aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO 2 ), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO 2 in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.

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Section: Discussionmentioning

confidence: 99%

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Misawa

Tanaka

Nabeshima

et al. 2012

J Nutr Sci Vitaminol

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“…whole plant or from some of its components is scanty and only a recent cause of interest (Gutterman & Chauser-Volfson 2000;Beppu et al 2006;Shin et al 2011;Misawa et al 2012). No information is available on the fate of active components from Aloe spp.…”

Section: Introductionmentioning

confidence: 99%

Administration ofAloe arborescenshomogenate to cattle: interaction with rumen fermentation and gut absorption of aloin

Bani

Grossi

Lucini

et al. 2016

Italian Journal of Animal Science

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Aloe has long been used as a traditional medicine for its numerous beneficial properties, which are mainly ascribed to b-polysaccharides and phenolic compounds including anthraquinones, anthrones and chromones. However, few studies on large animals are currently available. The effect of whole leaf Aloe arborescens homogenate on the in vitro rumen fermentative processes was tested using alfalfa hay and barley meal as substrates. The Aloe homogeneate was added at three different concentrations (0.4, 2.0 and 10.0 g L À1 of fermentation liquid). The same homogenate was dosed (200 g) orally and through the rumen cannula to three rumen cannulated heifers and orally to six lactating dairy cows to measure the rumen degradation of aloin and the transfer of aloin from the gut into the blood, respectively. The Aloe homogenate did not affect in vitro rumen fermentations and feed digestibility. The administration of Aloe homogenate did not negatively affect animal feed intake and health neither on the cannulated heifers nor on the dairy cows. Aloin underwent a rapid degradation in the rumen milieu, and became undetectable 2 h after oral dosage. However, when Aloe homogenate was administered to dairy cows, aloin appeared in blood as early as 2 h after administration, reached a maximum after 4 h (6.2 6 5.8 lg L À1 ) and progressively decreased thereafter. These results suggest that Aloe compounds can be absorbed into the blood and encourage the study of Aloe as a potential nutraceutical in ruminants. Further studies should determine the most effective in vivo dosage. ARTICLE HISTORY

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“…The hypoglycemic activity of Aloe species was first demonstrated by Agrawal (1985). Since then, the antidiabetic effects of Aloe preparations have been demonstrated in diabetic patients Ajabnoor 1990;Bunyapraphatsara et al, 1996;Yongchaiyudha et al 1996), and in alloxan-or streptozotocin-induced diabetic animal models (Beppu et al, 1993;Rajasekaran et al, 2004Rajasekaran et al, , 2005Rajasekaran et al, , 2006Beppu et al, 2006). A. vera gel was administered to STZ-induced diabetic rats decreased fasting blood glucose levels and improved the levels of the antioxidant enzyme (Nwanjo, 2006); moreover aqueous extract prevented the onset of hyperglycaemia in alloxan-induced diabetic rabbits (Akinmoladun and Akinloye, 2007) ) and aloe-emodin (3.6 mg g -1 ) was administered to insulin resistant mice for 4 weeks improved insulin tolerance and fasting blood glucose levels (Perez et al,2007).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Many of the health benefits associated withPolysaccharides from the plants were isolated using hot extraction method and then hydrolyzed. The polysaccharide hydrolysates were identified using high performance liquid chromatographic technique. Maximum yield of total polysaccharides identified were obtained from A 7 (12.04%), A 1 (8.51%), A 8 (8.03%), A 2 (5.32%) and A 6 (2.18%) respectively. The isolated polysaccharides were tested for antihyperglycemic activity in alloxan-induced diabetic rats and alpha glucosidase inhibitory activity. Chromatographic investigation of the polysaccharides recorded the presence of 18 saccharides, glucuronic acid, stachyose, galacturonic acid, sucrose, glucose, xylose, galactose, rhamnose, mannose, arabinose, fructose polyol, mannitol and sorbitol in the eight Aloe species, but their quantitative composition differed among the species. Glucuronic acid, stachyose and galacturonic acid were the major detected saccharides. The results of the biological activities revealed significant antihyperglycemic activities with variable degrees. After four weeks of daily administration, polysaccharides isolated from A. vera (A 1 ) and A. arborescens (A 2 ) were the most active with 40 and 44% reduction in blood glucose level, respectively. All the tested polysaccharides showed significant alpha glucosidase inhibitory activity with IC50 (µg/ml) 11.70, 14.60 and 15.80 for A 7 , A 6 and A 1 respectively. In conclusion, the tested polysaccharides contribute to the antidiabetic action of these Aloe species.

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Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: Investigation on hypoglycemic action and systemic absorption dynamics of aloe components

Cited by 75 publications

References 28 publications

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Administration of Dried Aloe vera Gel Powder Reduced Body Fat Mass in Diet-Induced Obesity (DIO) Rats

Administration ofAloe arborescenshomogenate to cattle: interaction with rumen fermentation and gut absorption of aloin

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

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