Antidiabetic effects of Nigella sativa are mediated by activation of insulin and AMPK pathways, and by mitochondrial uncoupling

Benhaddou-Andaloussi, Ali; Louis, Martineau C.; Vallerand, Diane; Haddad, Yara; Pierre, H

doi:10.1016/s1499-2671(08)24136-5

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides that, Fararh et al (2004) also highlighted the treatment of NS oil for 4 weeks in streptozotocin plus nicotinamide-induced diabetic hamsters caused a significant increase in serum insulin levels [35]. These hypoglycemic effects of NS have been reported to be regulated through the activation of insulin and AMP-activated protein kinase (AMPK) pathways [36].…”

Section: Discussionmentioning

confidence: 95%

Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review

Hamdan

Idrus

Mokhtar

2019

IJERPH

View full text Add to dashboard Cite

Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained wide attention from researchers and have been considered to be a beneficial adjuvant agent to oral antidiabetic drugs because of their integrated effects. Concerning the various beneficial effects of Nigella sativa, this systematic review aims to provide comprehensive information on the effects of Nigella sativa on glucose and insulin profile status in humans. A computerized database search performed through Scopus and Medline via Ebscohost with the following set of keywords: Nigella Sativa OR black seed oil OR thymoquinone OR black cumin AND diabetes mellitus OR hyperglycemia OR blood glucose OR hemoglobin A1C had returned 875 relevant articles. A total of seven articles were retrieved for further assessment and underwent data extraction to be included in this review. Nigella sativa was shown to significantly improve laboratory parameters of hyperglycemia and diabetes control after treatment with a significant fall in fasting blood glucose, blood glucose level 2 h postprandial, glycated hemoglobin, and insulin resistance, and a rise in serum insulin. In conclusion, these findings suggested that Nigella sativa could be used as an adjuvant for oral antidiabetic drugs in diabetes control.

show abstract

Section: Discussionmentioning

confidence: 95%

Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review

Hamdan

Idrus

Mokhtar

2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…Moreover, Ali et al [ 51 ] found that NS mediated its antidiabetic effects via activation of insulin and AMP-activated protein kinase (AMPK) pathways, and by mitochondrial uncoupling. NS was found to activate AKT and ERK1/2 in C2C12 myotubes to values nearly 50% greater than the vehicle dimethyl sulfoxide.…”

Section: Resultsmentioning

confidence: 99%

Nigella sativa L. and Its Active Compound Thymoquinone in the Clinical Management of Diabetes: A Systematic Review

Mahomoodally

Aumeeruddy²,

Legoabe³

et al. 2022

IJMS

View full text Add to dashboard Cite

Despite existing conventional hypoglycemic drugs to manage diabetes, their non-availability and cost in low-income countries coupled with the associated side effects remain a major concern. Consequently, exploring for alternative treatments to manage diabetes has been a continuous priority. Nigella sativa L. (NS) (Family: Ranunculaceae) is regarded as a valuable traditional remedy in diabetes management and extensively studied for its biological properties. This systematic review provides a comprehensive and critical analysis of clinical studies on the efficacy, safety, and mechanism of action of NS and its compound thymoquinone (TQ) in diabetes management. The main scientific databases which were scrutinised were Scopus, PubMed, Google Scholar, and Web of Science. Data search was conducted from inception to January 2022. A total of 17 clinical studies were obtained; 16 studies on Nigella sativa L. and 1 study on its compound TQ. N. sativa was found to be highly potent in terms of its hypoglycemic activity when compared to placebo based on improvement in parameters including fasting blood glucose (FBG), postprandial blood glucose (PPBG), Hemoglobin A1C (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), and homeostatic model assessment for assessment of beta-cell functionality (HOMA-β). The compound TQ in combination with a daily dose of metformin demonstrated a greater reduction in the levels of HbA1c and blood glucose compared to metformin alone. The bioavailability of TQ can be enhanced by using nanoparticulate drug delivery systems. Considering the findings of the clinical studies along with negligible adverse effects, NS has strong potential application in bioproduct development for the management of diabetes. Further investigations should explore the detailed mechanism of actions by which TQ exerts its therapeutic antidiabetic effects to provide more insights into its clinical use in the management of diabetes.

show abstract

“…Different studies reported that the possible hypoglycemic mechanisms of Nigella sativa were mediated by the activation of insulin and AMP-activated protein kinase (AMPK) pathways both in the muscle, where it promoted the synthesis and translocation of the glucose transporter 4 (GLUT4), and in the liver, where it inhibited gluconeogenesis. Furthermore, the anti-oxidant activity of Nigella sativa promoted the proliferation of β-pancreatic cells and their integrity, thus improving insulin secretion [31][32][33]. In addition, an in vitro study showed the inhibitory effect of Nigella sativa extract against intestinal α-glucosidase and pancreatic α-amylase, resulting in reduced bowel glucose absorption [34].…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

The Use of Nigella sativa in Cardiometabolic Diseases

Derosa,

D’Angelo,

Maffioli

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Nigella sativa L. is an herb that is commonly used in cooking and in traditional medicine, particularly in Arab countries, the Indian subcontinent, and some areas of eastern Europe. Nigella sativa is also called “black cumin” or “black seeds”, as the seeds are the most-used part of the plant. They contain the main bioactive component thymoquinone (TQ), which is responsible for the pleiotropic pharmacological properties of the seeds, including anti-oxidant, anti-inflammatory, anti-hypertensive, anti-hepatotoxic, hypoglycemic, and lipid-lowering properties. In this narrative review, both the potential mechanisms of action of Nigella sativa and the fundamental role played by pharmaceutical technology in optimizing preparations based on this herb in terms of yield, quality, and effectiveness have been outlined. Moreover, an analysis of the market of products containing Nigella sativa was carried out based on the current literature with an international perspective, along with a specific focus on Italy.

show abstract

Antidiabetic effects of Nigella sativa are mediated by activation of insulin and AMPK pathways, and by mitochondrial uncoupling

Cited by 7 publications

References 0 publications

Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review

Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review

Nigella sativa L. and Its Active Compound Thymoquinone in the Clinical Management of Diabetes: A Systematic Review

The Use of Nigella sativa in Cardiometabolic Diseases

Contact Info

Product

Resources

About