Antidiabetic effects of selenium-enriched <i>Bifidobacterium longum</i> DD98 in type 2 diabetes model of mice

Zhao, Dan; Zhu, Hui; Gao, Fei; Qian, Zhixiang; Mao, Wenwei; Yu, Yin; Tan, Jun; Chen, Daijie

doi:10.1039/d0fo00180e

Cited by 49 publications

(45 citation statements)

References 48 publications

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“…This can be exemplified by an earlier study that used rabbits treated with Lactobacillus acidophilus ( Mega acidophilus ) with a dose of 2 × 10 8 cfu/kg weight/day during a period of 4 weeks [ 34 ]. Thus, the hypoglycemic effect of these probiotics could have a positive impact on the prevention of type 2 diabetes in animals and humans, in agreement with other studies [ 35 ].…”

Section: Resultssupporting

confidence: 90%

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Kadja

Dib

Lakhdara

et al. 2021

Biology

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This study aimed to investigate the effects of three strains of probiotics, these being Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745, on the body weight, animal performances and blood parameters of rabbits (male and female) of the ITELV2006 strain. The supplementation of the feed of the rabbits with the three probiotic strains allowed observing positive effects on most of the biochemical and haematological parameters investigated during a period of 60 days (30 days of supplementation and 30 days without treatment). Further, there was a significant improvement in the body weight of the rabbits at the end of the experiment. The effect of the three probiotics investigated in this trial was found to be related to the sex of the rabbits and to the intake period (duration). Ultimately, these findings raise the possibility of using probiotics to investigate in an in-depth and specific manner based on fixed factors such as the strain, the gender and age of the animals, the main underlying mechanisms and effects, which would allow achieving optimal and adapted health benefits and sustainable production. In the context of animal production, it is worth investigating in a targeted study the effect of the three strains on muscle growth and development and finding evidence of the possible consequences on meat quality traits of the rabbits supplemented with probiotics.

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Section: Resultssupporting

confidence: 90%

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Kadja

Dib

Lakhdara

et al. 2021

Biology

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“…In this study, at week 0, there were no significant differences among the tested mice, whereas at week 12, mice fed a high-fat diet all had higher FBG levels than mice fed a normal diet. Additionally, recent research has shown that probiotic treatment, especially with Bifidobacterium species, may contribute to FBG levels and AUC values [26,27]. Our results also demonstrated that TMC3115 was associated with a decreased trend in FBG levels in mice but did not improve the AUC values.…”

Section: Discussionsupporting

confidence: 60%

Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice

et al. 2021

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Background Accumulating evidence have shown that the intestinal microbiota plays an important role in prevention of host obesity and metabolism disorders. Recent studies also demonstrate that early life is the key time for the colonization of intestinal microbes in host. However, there are few studies focusing on possible association between intestinal microbiota in the early life and metabolism in adulthood. Therefore the present study was conducted to examine whether the short term antibiotic and/or probiotic exposure in early life could affect intestinal microbes and their possible long term effects on host metabolism. Results A high-fat diet resulted in glucose and lipid metabolism disorders with higher levels of visceral fat rate, insulin-resistance indices, and leptin. Exposure to ceftriaxone in early life aggravated the negative influences of a high-fat diet on mouse physiology. Orally fed TMC3115 protected mice, especially those who had received treatment throughout the whole study, from damage due to a high-fat diet, such as increases in levels of fasting blood glucose and serum levels of insulin, leptin, and IR indices. Exposure to ceftriaxone during the first 2 weeks of life was linked to dysbiosis of the fecal microbiota with a significant decrease in the species richness and diversity. However, the influence of orally fed ceftriaxone on the fecal microbiota was limited to 12 weeks after the termination of treatment. Of note, at week 12 there were still some differences in the composition of intestinal microbiota between mice provided with high fat diet and antibiotic exposure and those only fed a high fat diet. Conclusions These results indicated that exposure to antibiotics, such as ceftriaxone, in early life may aggravate the negative influences of a high-fat diet on the physiology of the host animal. These results also suggest that the crosstalk between the host and their intestinal microbiota in early life may be more important than that in adulthood, even though the same intestinal microbes are present in adulthood.

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“…In addition, the administration of Se nanoparticles (0.9 mg/kg) demonstrated an increase in butyrate and in the amounts of beneficial bacteria such as Lactobacillus and Faecalibacterium (160). High concentrations of butyric acid, acetic acid, and isobutyric acid were identified in the feces of mice after oral administration of B. longum DD98, Se-B (157).…”

Section: Selenium Microbiota and Glycemic Disordersmentioning

confidence: 99%

“…The mechanism discussed involves the probiotic-gut flora-butyrate-GLP-1 axis which is capable of promoting enhanced metabolic efficiency. Considering that supplementation with B. longum DD98, Se-B also resulted in increased secretion of GLP-1 and protected β cells, it has been speculated whether Se acts on this axis as a modulator of the deleterious effects caused by DM (157).…”

Section: Selenium Microbiota and Glycemic Disordersmentioning

confidence: 99%

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

et al. 2021

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This review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host's selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host's selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteria.

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Antidiabetic effects of selenium-enriched Bifidobacterium longum DD98 in type 2 diabetes model of mice

Abstract:
Se-B. longum DD98 have shown antidiabetic effects in a type 2 diabetes model.

Cited by 49 publications

References 48 publications

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

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Antidiabetic effects of selenium-enriched Bifidobacterium longum DD98 in type 2 diabetes model of mice

Abstract: Se-B. longum DD98 have shown antidiabetic effects in a type 2 diabetes model.

Cited by 49 publications

References 48 publications

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits

Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice

Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases

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Abstract:
Se-B. longum DD98 have shown antidiabetic effects in a type 2 diabetes model.