Antidiabetic effects of Syzygium cumini leaves: A non-hemolytic plant with potential against process of oxidation, glycation, inflammation and digestive enzymes catalysis

Zabisky, Luiz Fernando Ribeiro; Júnior, Joed Pires de Lima; Alves, Victor Hugo Mota; Justino, Allisson Benatti; Saraiva, André Lopes; Goulart, Luíz Ricardo; Espíndola, Foued Salmen

doi:10.1016/j.jep.2020.113132

Cited by 39 publications

(27 citation statements)

References 66 publications

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“…Plants and microorganisms are rich sources of α-glucosidase inhibitors. For example, acarbose, 1-deoxynojirimycin, and genistein were originally isolated from natural sources [ 59 ]. E. hirta L., which is a traditional plant used for various disease treatments, has been under investigation as an α-glucosidase inhibitor.…”

Section: Polyphenols and Plant Familiesmentioning

confidence: 99%

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Riyaphan¹,

Pham

Leong

et al. 2021

Biomolecules

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Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose with surplus adverse effects, leading to efforts devoted to urgently seeking new anti-diabetes drugs from natural sources for delayed starch digestion. This review attempts to explore 10 families e.g., Bignoniaceae, Ericaceae, Dryopteridaceae, Campanulaceae, Geraniaceae, Euphorbiaceae, Rubiaceae, Acanthaceae, Rutaceae, and Moraceae as medicinal plants, and folk and herb medicines for lowering blood glucose level, or alternative anti-diabetic natural products. Many natural products have been studied in silico, in vitro, and in vivo assays to restrain hyperglycemia. In addition, natural products, and particularly polyphenols, possess diverse structures for exploring them as inhibitors of α-glucosidase and α-amylase. Interestingly, an in silico discovery approach using natural compounds via virtual screening could directly target α-glucosidase and α-amylase enzymes through Monte Carto molecular modeling. Autodock, MOE-Dock, Biovia Discovery Studio, PyMOL, and Accelrys have been used to discover new candidates as inhibitors or activators. While docking score, binding energy (Kcal/mol), the number of hydrogen bonds, or interactions with critical amino acid residues have been taken into concerning the reliability of software for validation of enzymatic analysis, in vitro cell assay and in vivo animal tests are required to obtain leads, hits, and candidates in drug discovery and development.

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Section: Polyphenols and Plant Familiesmentioning

confidence: 99%

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Riyaphan¹,

Pham

Leong

et al. 2021

Biomolecules

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“…Recent databases suggest that different plant parts including skin and pulps, essential oils, seeds, flowers, barks, and leaves have different and characteristic compositions (Table 2) [26][27][28][29][30][31]. The purple shade of S. cumini fruit is due to the presence of anthocyanins, whereas its astringent flavor is imparted by a high concentration of tannins [15].…”

Section: Phytochemical Profilementioning

confidence: 99%

“…Furthermore, 3,5-diglucosides of malvidin, delphinidin, and petunidin were identified in S. cumini peels [26,27]. Bioactive components such as phenolic acids, gallic acid, ellagic acid, carotenoids, flavonoids, myricetin, and their derivatives were identified in fruit pulps [28,29]. About 30 compounds such as terpinyl isovalerate, dihydrocarvyl acetate, and geranyl butyrate contribute to the flavor of the purple fruits [30].…”

Section: Phytochemical Profilementioning

confidence: 99%

“…S. cumini leaf extract protected against paraquat-induced toxicity in Saccharomyces cerevisiae strains deficient in SOD owing to higher antioxidant activity [68]. Sequentially extracted ethyl acetate and n-butanol fractions of S. cumini leaves delineated notable radical-scavenging activity in the DPPH assay with IC 50 15.7 and 23.5 µg/mL, 1155 and 1178 µmol TE/g in the FRAP assay, and 1225 and 1314 µmol TE/g in the ORAC assay [29]. In addition, the S. cumini methanol fruit extract exhibited strong antioxidant properties in the DPPH (IC 50 81.4 µg/mL), FRAP (46.0 mmol Fe/g), and H 2 O 2 (76% inhibition) assays as compared to 50% aqueous methanol and dichloromethane extracts [37].…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Qamar

Akhtar

Ismail

et al. 2022

Foods

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Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the Myrtaceae family. This study aims to summarize the most recent literature related to botany, traditional applications, phytochemical ingredients, pharmacological activities, nutrition, and potential food applications of S. cumini. Traditionally, S. cumini has been utilized to combat diabetes and dysentery, and it is given to females with a history of abortions. Anatomical parts of S. cumini exhibit therapeutic potentials including antioxidant, anti-inflammatory, analgesic, antipyretic, antimalarial, anticancer, and antidiabetic activities attributed to the presence of various primary and secondary metabolites such as carbohydrates, proteins, amino acids, alkaloids, flavonoids (i.e., quercetin, myricetin, kaempferol), phenolic acids (gallic acid, caffeic acid, ellagic acid) and anthocyanins (delphinidin-3,5-O-diglucoside, petunidin-3,5-O-diglucoside, malvidin-3,5-O-diglucoside). Different fruit parts of S. cumini have been employed to enhance the nutritional and overall quality of jams, jellies, wines, and fermented products. Today, S. cumini is also used in edible films. So, we believe that S. cumini’s anatomical parts, extracts, and isolated compounds can be used in the food industry with applications in food packaging and as food additives. Future research should focus on the isolation and purification of compounds from S. cumini to treat various disorders. More importantly, clinical trials are required to develop low-cost medications with a low therapeutic index.

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“…Aqueous extract exhibited minimum (3 %) red blood cells protective potential. Current results can be justified by the fact that hydroxyl groups of the plant polyphenols scavenge the free radicals and protect blood cells [40,41].…”

Section: Blood Protection Activitymentioning

confidence: 99%

Probing the Comparative Bioefficacy of Allium sativum L. Bulb through Different Solvents

Hussain¹,

Shahid²,

Zulfiqar³

et al. 2021

J. Mex. Chem. Soc.

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Abstract. Allium sativum (garlic), an aromatic bulbous plant is one of the most vital and oldest authenticated herbs which has been utilized from ancient times as a traditional medicine. A. sativum has cardioprotective, antimicrobial, anti-inflammatory, antidiabetic, antioxidant and anticancer properties due to a large range of phenolic compounds and sulfur containing compounds. The current study was conducted to assess the antioxidant chemistry, and numerous bioactivities of A. sativum bulbs extracts in different solvents. Ethanol fraction was the most active antioxidant and showed maximum total phenolic content (16.18 g GAE/100 g), total flavonoid content (95.04 g CE/100 g) and free radical scavenging activity (75.50 %). Methanol (4 %) fraction exhibited maximum antiglycation activity. Aqueous, n-hexane and ethyl acetate fractions exhibited maximal (52 %, 24 % and 38 %) inhibitions of alpha-amylase, alpha-glucosidase and acetylcholinesterase respectively. In an antimicrobial assay, ethanol (59.05 %) and chloroform (72.92 %) fractions showed maximum inhibition of Pasturella multocida and Staphylococcus aureus strains respectively. n-butanol and n-hexane fractions showed maximum (31 %) antihemolytic activity and (20 %) thrombolytic activities respectively. A. sativum bulb extracts and fractions have noteworthy bio-efficacies that holds promise to be used as a source of natural drug to cure various disorders. Resumen. Allium sativum (ajo), una planta bulbosa aromática, es una de las hierbas autenticadas más vitales y antiguas que se han utilizado desde la antigüedad como medicina tradicional. A. sativum tiene propiedades cardioprotectoras, antimicrobianas, anti-inflamatorias, anti-diabéticas, anti-oxidantes y anti-cancerígenas debido a una amplia gama de compuestos fenólicos y compuestos que contienen azufre. El estudio actual se llevó a cabo para evaluar la química antioxidante y numerosas bioactividades de extractos de rizoma de A. sativum en diferentes disolventes. La fracción de etanol tuvo la mayor actividad antioxidante y mostró un contenido fenólico total máximo (16.18 g GAE / 100 g), contenido total de flavonoides (95.04 g CE / 100 g) y actividad captadora de radicales libres (75.50 %). La fracción de metanol (4 %) exhibió la mayor actividad de antiglicación. Las fracciones acuosa, de n-hexano y de acetato de etilo inhibieron la actividad de alfa-amilasa, alfa-glucosidasa y acetilcolinesterasa, en 52 %, 24 % y 38 % respectivamente. En el ensayo antimicrobiano, las fracciones de etanol (59.05 %) y cloroformo (72.92 %) mostraron una inhibición máxima de las cepas de Pasturella multocida y Staphylococcus aureus, respectivamente. Las fracciones de n-butanol y n-hexano mostraron actividad anti-hemolítica (31 %) y trombolítica (20 %) respectivamente. Los extractos y fracciones de rizoma de A. sativum tienen bioeficacia notable con potencial de ser utilizadas como una fuente de fármaco natural para curar diversos trastornos.

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Antidiabetic effects of Syzygium cumini leaves: A non-hemolytic plant with potential against process of oxidation, glycation, inflammation and digestive enzymes catalysis

Cited by 39 publications

References 66 publications

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Probing the Comparative Bioefficacy of Allium sativum L. Bulb through Different Solvents

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