Antidiabetic effects of three Korean sorghum phenolic extracts in normal and streptozotocin-induced diabetic rats

Sorghum: An Underutilized Cereal Whole Grain with the Potential to Assist in the Prevention of Chronic Disease

“…(88,99,110) In animal studies, sorghum tannins have been shown to be [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] fold more effective at quenching peroxyl radicals than simple phenolics. (111) The presence of tannins in sorghum grain may reduce the nutritive value and lower metabolizable energy of the grain. Several mechanisms have been proposed to explain this "anti-nutritional" effect as reviewed by Awika and Rooney.…”

“…Numerous animal feeding studies have shown that sorghum in the diet effectively improves glucose metabolism compared to sorghum-free diets. (111,(160)(161)(162) A limitation in some of these studies is that the specific type of sorghum extract is not defined, thus it cannot be determined whether effects are linked to phenolic, fiber or macronutrient contents.…”

“…(111,159,161,(165)(166)(167) Klopfenstein et al (168) concluded that sorghum bran was effective in lowering serum and liver cholesterol levels in hamsters. This effect was repeated in another hamster model of hypercholesterolemia, when grain sorghum lipid extract included in the diet significantly reduced plasma non-HDL and liver esterified cholesterol levels while increasing HDL levels.…”

Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin–induced diabetic rats

“…Diabetic rats were divided into 5 groups and were daily treated from days 1 to 21 as follows: 2 groups received AHE at the doses of 250 and 500 mg/kg, respectively; group 3 received glibenclamide (10 mg/kg); group 4 were untreated diabetic control (DC) rats; group 5 were the normal control (NC) group and received vehicle. The blood glucose level was determined in fasted rats before administration of drugs (day 1) and at weekly interval by retro orbital puncture under light ether anesthesia.…”

“…Plants containing natural antioxidants (tannins, flavonoids, vitamins C and E) can preserve 毬 -cell function and prevent diabetes induced ROS formation [3] . Polyphenols, which are classified into many groups such as flavonoids, tannins, stilbenes with known health-beneficial properties, which include free radical scavenging, inhibition of hydrolytic and oxidative enzymes, anti-inflammatory action and antidiabetogenic potentiality [4] .…”