Antidiarrheal and antispasmodic activities of &lt;i&gt;Adiantum capillus-veneris&lt;/i&gt; are predominantly mediated through ATP-dependent K+ channels activation

Janbaz, Khalid Hussain; Hassan, Waseem; Mehmood, Malik Hassan; Gilani, Anwarul Hassan

doi:10.3329/bjp.v10i1.21869

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…The antispasmodic effects of A. capillus-veneris and T. terrestris have been shown previously. [ 19 57 ]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial

Samandarian,

Soltani,

Hajhashemi

et al. 2023

Journal of Research in Pharmacy Practice

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Objective: The high prevalence of urolithiasis and its recurrence entail the preparation of an efficient drug with the least side effects. Tribulus terrestris, Urtica dioica, Adiantum capillus-veneris, Stigma maydis (corn silk), and Cucumis melo are herbal remedies utilized in traditional medicine for urolithiasis. This study aimed to assess the efficiency of these plants’ extracts in treating urolithiasis. Methods: In a randomized, single-blind, placebo-controlled clinical trial, participants meeting inclusion criteria were randomly allocated to the drug (n = 27) and placebo (n = 27) groups to take herbal or placebo solutions, respectively, at a dose of 60 drops 3 times daily for 4 weeks with standard treatment. Before and after the intervention, 24-h urine volume and the quantities of calcium, sodium, citrate, oxalate, urea, creatinine, and uric acid in 24-h urine, and urinary pH were measured. The number and size (diameter in mm) of stones were determined by ultrasonography and recorded for each patient. Findings: Except for 24 h urine volume, other urinary parameters did not alter significantly at the end of the intervention compared to baseline. Furthermore, the two groups had no significant difference regarding these indices. Regarding stone parameters, the stone size decreased significantly in the drug group compared to the placebo group (P = 0.049). The number of cases with complete stone expulsion in the drug group was significantly higher than in the placebo group (12 cases vs. 4 cases, respectively, P = 0.017). Conclusion: Oral consumption of the herbal solution causes stone size reduction and stone expulsion in patients with urolithiasis.

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“…The antispasmodic effects of A. capillus-veneris and T. terrestris have been shown previously. [ 19 57 ]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial

Samandarian,

Soltani,

Hajhashemi

et al. 2023

Journal of Research in Pharmacy Practice

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“…After that, the same procedure was repeated in the presence of glibenclamide and verapamil. The relaxation of isolated tissue preparations was expressed as a percentage of the control response mediated by adding low and high K + concentrations [20].…”

Section: Methodsmentioning

confidence: 99%

The Spasmolytic Effect of Astragalus Sarcocolla on the Intestinal Smooth Muscles of Rabbit In Vitro: Potassium Channel Opening

Siddiqui

Mazhar

Malik

et al. 2020

Cureus

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Introduction Astragalus species have been widely used in Chinese herbal medicine to treat gastrointestinal and inflammatory disorders. This study was conducted to evaluate the efficacy of Astragalus sarcocolla (ASE) and to rationalize its medicinal use as an antispasmodic drug for the treatment of spasmodic gastrointestinal and inflammatory disorders associated with increased intestinal motility. Methods The ethanolic extract of ASE was studied to examine its antispasmodic effect on the isolated rabbit ileum preparations, and the contractions were recorded on PowerLab (ADInstruments, Sydney, Australia). Results ASE was able to inhibit spontaneous ileum contractions. It also completely inhibited K + (25 mM)-induced contractions but was unable to inhibit high K + (80 mM)-induced sustained contractions. Pretreatment of the tissue with glibenclamide, a potassium channel blocker, caused a rightward shift of the dose-response curve when stimulated with K + (25 mM) in the presence of an increasing concentration of the extract. Verapamil at very low doses inhibited both the 25 mM and 80 mM K +-induced contractions. Conclusion The results of our study demonstrated the spasmolytic activity of ASE with the potential mechanism of activation of K + ATP, which provides a strong basis for its medicinal use in motility and inflammatory disorders of the intestine.

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Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

Rawat

Singh

Kumar

2017

Biomedicine & Pharmacotherapy

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Antidiarrheal and antispasmodic activities of <i>Adiantum capillus-veneris</i> are predominantly mediated through ATP-dependent K+ channels activation

Cited by 6 publications

References 24 publications

Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial

Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial

The Spasmolytic Effect of Astragalus Sarcocolla on the Intestinal Smooth Muscles of Rabbit In Vitro: Potassium Channel Opening

Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

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