Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

Rawat, Pooja; Singh, Pawan; Kumar, Vipin

doi:10.1016/j.biopha.2017.11.147

Cited by 45 publications

(28 citation statements)

References 126 publications

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“…The overall factors cause an accumulation of water, Na + and K + in the lumen of the intestine. 28,29 CAF is evident to decrease the production and release of NO in experimental animals. 30 Moreover, CAF is also found to decrease the levels of pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-3, -6 and -12 and nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) via inhibitor of nuclear factor kappa B (IκBα) phosphorylation in zebrafish.…”

Section: Discussionmentioning

confidence: 92%

Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway

Faria¹,

Hassan²,

Hossain³

et al. 2020

IJPER

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Section: Discussionmentioning

confidence: 92%

Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway

Faria¹,

Hassan²,

Hossain³

et al. 2020

IJPER

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“…Laxatives such as castor oil induce diarrhea by increased motility and/or gastrointestinal secretions via its active ingredient, the ricinoleic acid. Ricinoleic acid modifies the permeability of the intestinal mucosa to electrolytes [26] by inhibiting the intestinal Na + /K + ATPase activity [8] and stimulating the biosynthesis and release of the endogenous prostaglandins responsible for diarrhea [27]. In this study, the hydroethanolic extract of Bixa orellana leaves at 200 mg/kg bw significantly and maximumly (88%) reduced the amount and frequency of castor oil-induced diarrheal stools in mice, unlike the methanolic extract which showed maximal inhibition (85%) at 500 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice

Tagne

Akaou

Noubissi

et al. 2019

Gastroenterology Research and Practice

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Objective The treatment of diarrheal diseases is a serious problem in developing countries, where population generally uses medicinal plants. The leaves of Bixa orellana have been reported to be traditionally used in the treatment of diarrhea by local people in the district of Khulna in Bangladesh. The aim of this study was to investigate the effects of the hydroethanolic extract of Bixa orellana leaves on castor oil-induced diarrhea in mice. Methods The powder of the leaves of Bixa orellana was macerated in ethanol/water mixture (20/80) for 48 hours and then filtered. The filtrate obtained was lyophilized, and the solutions to be administered to the animals were prepared. To induce diarrhea, animals orally received castor oil (1 mL/100 g bw). To determine the effective doses, each mouse received, 30 minutes after the administration of castor oil, one of the single oral doses of hydroethanolic extract of Bixa orellana leaves: 0, 25, 50, 100, and 200 mg/kg bw. The mass, number, and frequency of stool diarrhea were measured and recorded per hour for five hours. The effect of the hydroethanolic extract of Bixa orellana leaves on the intestinal transit was evaluated by measuring the distance traveled by the charcoal meal in thirty minutes. The effects of the aqueous extract of hydroethanolic extract of Bixa orellana leaves on intestinal secretion were evaluated by measuring the volume of the intestinal content and by dosing the electrolytes (Na+, K+, and Cl−) in the intestinal content by the colorimetric method. Results The extract produced significant (P < 0.01) decreases, respectively, 35.52%, 54.47%, 74.80%, and 87.80% in the severity of diarrhea. The extract at 100 and 200 mg/kg bw showed a significant (P < 0.01) decrease of castor oil-induced enteropooling (61.08% and 65.41%), and only the 200 mg/kg bw exhibited significant (P < 0.01) reduction on intestinal transit (24.46%) as compared to standard drug. Conclusions The hydroethanolic extract was found to be effective against castor oil-induced diarrhea in experimental mice at 50, 100, and 200 mg/kg bw which provides evidence that could justify its traditional use.

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“…adenosine monophosphate (cAMP) concentration. This increase in cAMP concentration (a) stimulates peristaltic activity in the intestine, (b) alters the membrane permeability, (c) reduces the activity of the Na + K + ATPase pump, and (d) decreases the absorption of Na + and K + ; these factors can cause an accumulation of these electrolytes and water in the intestinal lumen (20,21). Our findings from this study, suggest that PHY and the standards (LOP, PRA, PRO, NIF) significantly (p < 0.05) increase latent periods in diarrheal mice when compared to the VEH group.…”

Section: Under Investigation Gr-viii: (Gr-ii + Gr-iv)mentioning

confidence: 99%

Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models

Islam

Rahman

Saeed

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Phytol (PHY), a chlorophyll-derived diterpenoid, exhibits numerous pharmacological properties, including antioxidant, antimicrobial, and anticancer activities. This study evaluates the anti-diarrheal effect of phytol (PHY) along with its possible mechanism of action through in-vivo and in-silico models. The effect of PHY was investigated on castor oil-induced diarrhea in Swiss mice by using prazosin, propranolol, loperamide, and nifedipine as standards with or without PHY.PHY at 50 mg/kg (p.o.) and all other standards exhibit significant (p < 0.05) anti-diarrheal effect in mice. The effect was prominent in the loperamide and propranolol groups. PHY co-treated with prazosin and propranolol was found to increase in latent periods along with a significant reduction in diarrheal section during the observation period than other individual or combined groups. Furthermore, molecular docking studies also suggested that PHY showed better interactions with the α-and β-adrenergic receptors, especially with α-ADR1a and β-ADR1. In the former case, PHY showed interaction with hydroxyl group of Ser192 at a distance of 2.91Å, while in the latter it showed hydrogen bond interactions with Thr170 and Lys297 with a distance of 2.65 and 2.72Å, respectively. PHY exerted significant anti-diarrheal effect in Swiss mice, possibly through blocking α-and β-adrenergic receptors.

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Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

Cited by 45 publications

References 126 publications

Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway

Anti-diarrheal Activity of Caffeine: A Modulatory Effect with Loperamide and through 6FH5 (PIK3CG) Protein Interaction Pathway

Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice

Anti-diarrheal activities of phytol along with its possible mechanism of action through in-vivo and in-silico models

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