Antidiarrhoeal and intestinal modulatory activities of Wei-Chang-An-Wan extract

Hu, Jing; Gao, Wenyuan; Ling, Ning-Sheng; Liu, Changxiao

doi:10.1016/j.jep.2009.07.027

Cited by 39 publications

(41 citation statements)

References 28 publications

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“…Diseases of the GI tract are highly common and varied, including irritable bowel syndrome, functional dyspepsia, abdominal pain, abdominal bloating, nausea, vomiting, diarrhoea, constipation, etc., which have a substantial effect on quality of life and healthcare costs (Hu et al, 2009). M. officinalis is commonly used in TCM for treating such GI disorders, probably through an antispasmodic effect that results in relaxation of GI tract smooth muscles (Chan et al, 2008;Lee et al, 2011).…”

Section: Treatment Of Gastrointestinal Disordersmentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

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Section: Treatment Of Gastrointestinal Disordersmentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

View full text Add to dashboard Cite

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“…Weichang'an Pill, a traditional Chinese medicine (TCM) formula, has been used to treat irritable bowel syndrome and functional diarrhea for several decades (Hu et al, 2009;Liu et al, 2013;Wang et al, 2012). As a main component in Weichang'an pill, RA accounts for 25% of the prescription.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal effect of methanol extract ofRadix Aucklandiaeand selected active substances on the transit activity of rat isolated intestinal strips

Guo

Zhang

Gao

et al. 2014

Pharmaceutical Biology

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Context: Radix Aucklandiae, the dry rhizome of Aucklandia lappa Decne (Asteraceae), enjoyed traditional popularity for its antidiarrheal effects. Although there are many investigations on its chemical constituents and pharmacologic actions, few studies explaining its activity and mechanism in gastrointestinal disorders are available. Objective: In this paper, we focused on the effects of the methanol extract of R. Aucklandiae (RA ext) on gastrointestinal tract, so as to assess some of the possible mechanisms involved in the clinical treatment. Materials and methods: In vivo, in neostigmine-induced mice and normal mice, after intragastric administration, RA ext (100, 200, 300, and 400 mg/kg) was studied on gastrointestinal transit including gastric emptying and small intestinal motility. Meanwhile, in vitro, the effect of it (0.1, 0.2, 0.3, and 0.4 mg/mL) on the isolated tissue preparations of rat jejunum was also investigated, as well as costunolide and dehydrocostuslactone which were the main constituents. Results: In vivo, the gastric emptying increased and intestinal transit decreased after the administration of RA ext in normal mice. However, RA ext inhibited the gastric emptying and the intestinal transit throughout the concentrations in neostigmine-induced mice. In vitro, RA ext caused inhibitory effect on the spontaneous contraction of rat-isolated jejunum in a dose-dependent manner ranging from 0.1 to 0.4 mg/mL, and it also relaxed the acetylcholine chloride (Ach, 10 À5 M), 5-hydroxytryptamine (5-HT, 200 mM)-induced, and K + (60 mM)-induced contractions. RA ext shifted the Ca 2+ concentration-response curves to right, similar to that caused by verapamil (0.025 mM). The Ca 2+ concentration-response curves were shifted by costunolide (CO) (5.4, 8.1, and 10.8 mg/mL), dehydrocostuslactone (DE) (4.6, 6.9, and 9.2 mg/mL), costunolide-dehydrocostuslactone (CO-DE) (5. 4-4.6, 8.1-6.9, and 10.8-9.2 mg/mL) to the right, similar to that caused by verapamil (0.01 mM). Discussion and conclusion: These results indicate that RA ext played a spasmolytic role in gastrointestinal motility, which is probably mediated through the inhibition of muscarinic receptors, 5-HT receptors, and calcium influx. The presence of cholinergic and calcium antagonist constituents may be the compatibility of CO and DE. All these results provide a pharmacological basis for its clinical use in the gastrointestinal tract. KeywordsCholinergic and calcium antagonist, gastric emptying, intestinal smooth muscle, small intestinal motility History

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“…As previously described (Hu et al, 2009), WCAW was prepared with 10 herbs: 25% the dried root of Aucklandia lappa, 10% the resinous wood of Aquilaria sinensis, 15% the immature fruit of Citrus aurantium, 15% the dried bark of Magnolia officinalis, 10% the duramen of Santalum album, 7% the dried rhizoma of Rheum officinale, 5% the mature fruit of Cronton tiglium L. (Euphorbiaceae), 0.5% Moschus moschi ferus Linnaeus, 5% the dried rhizoma of Ligusticum chuanxiong and 7.5% the fruit of Ziziphus jujuba Mill (Rhamnaceae) mill in Tianjin Lerentang Pharmaceutical Factory. These herbs were purchased from Medicinal Material Company (Hebei Province, China) and identified by Professor Wen-Yuan Gao, and all the voucher specimens (No.…”

Section: Plant Materials and Preparation Of Different Extracts Of Wcawmentioning

confidence: 99%

“…Currently, WCAW is found to relieve functional gastrointestinal disorders such as irritable bowel syndrome (Liu et al, 2010) and inflammatory bowel disease (Dai et al, 2010). In our previous work, WCAW was certified for antidiarrheal (Hu et al, 2009) and anti-inflammatory activities in animal models. Therefore, the present study was to investigate the antinociceptive activity of WCAW in three different animal models.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

Liu

Zhang

Gao

et al. 2013

Pharmaceutical Biology

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Context: Currently, famous traditional Chinese medicine formulas have undergone re-evaluation and development in China. Wei-Chang-An-Wan (WCAW) as one of them has been used for treating various gastrointestinal diseases for several decades. The secondary development of WCAW is in progress so as to interpret the effective material basis or find new pharmacological activity. Objective: To evaluate the antinociceptive effect of methanol extract of WCAW (ME) as well as four fractions (P.E., EtOAc, n-BuOH, H 2 O) and obtain information on the correlation between the contents of the fractions and antinociceptive effect. Materials and methods: ME was divided into four parts extracted by petroleum ether, ethyl acetate and n-butanol. Antinociceptive activity was evaluated by three models of acetic acid-induced writhing, formalin and hot-plate test in mice after repetitive administration of ME at 200, 400 or 800 mg/kg, P.E. 132 mg/kg, EtOAc 106 mg/kg, n-BuOH 176 mg/kg and H 2 O 176 mg/kg for six days. The chemical compounds were analyzed by HPLC-ESI-MS. Results: ME at 800 mg/kg inhibited acid-induced writhing by 84.69%, and reduced the licking time of second phase in formalin test by 53.23%. The inhibition rates in acid-induced writhing of P.E., EtOAc, n-BuOH and H 2 O were 27.79, 33.85, 38.97 and 37.69%, respectively, and in formalin test about 50%. They had no effect on the hot-plate test. HPLC-ESI-MS analysis showed that 68 chemical compounds were detected and 41 compounds were identified from ME. Discussion and conclusion: The results obtained herein indicate that WCAW possesses the antinociceptive activity that provides a new aspect in clinical application.

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Antidiarrhoeal and intestinal modulatory activities of Wei-Chang-An-Wan extract

Cited by 39 publications

References 28 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Gastrointestinal effect of methanol extract ofRadix Aucklandiaeand selected active substances on the transit activity of rat isolated intestinal strips

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

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