Antidiuretic response of a horse affected with pituitarypars intermediadysfunction to desmopressin acetate

Abstract

SummaryCentral diabetes insipidus (DI) was diagnosed in a 20-year-old American Quarter Horse gelding that was concomitantly affected with pituitary pars intermedia dysfunction (PPID). The diagnosis of DI was supported by a positive response to administered desmopressin acetate. Diagnosis of PPID was supported by physical appearance and elevated plasma adrenocorticotropic hormone concentration following domperidone administration. The horse's physical condition improved following treatment with pergolide but long-term treatment with desmopressin was not undertaken and severe polyuria and polydipsia persisted. Desmopressin acetate appears to be useful for the diagnosis of DI in mature horses concomitantly affected with PPID.

Current best practice in clinical management of equine endocrine patients

“…As mentioned above, polyuria and polydipsia are encountered in horses with advanced PPID and result from the reduced action of antidiuretic hormone on the kidney, as described in a recent report by Moses et al . (). Hypertriglyceridaemia is also a concern when horses enter negative energy balance, as occurs with colic, dental disease or systemic illness.…”

Long‐term hormone replacement treatment in a horse with central diabetes insipidus

“…Although in small animals, CDI is often acquired and idiopathic, it is also associated with trauma, pituitary neoplasia, PPID, and encephalitis . In horses, CDI has been described as an idiopathic syndrome, in association with encephalitis or PPID . The cause of CDI in the horse in the current case report was not further investigated, but because of the young age and lack of other clinical signs or laboratory abnormalities, the PPID, pituitary neoplasia, and encephalitis were considered unlikely.…”

“…3,4,8 In horses, CDI has been described as an idiopathic syndrome, 6,9 in association with encephalitis 10 or PPID. 11 The cause of CDI in the horse in the current case report was not further investigated, but because of the young age and lack of other clinical signs or laboratory abnormalities, the PPID, pituitary neoplasia, and encephalitis were considered unlikely. Also, the fact that the horse remained neurologically normal over a period of 5 years makes neoplasia very unlikely.…”

Equine PPID or PPIH?

“…In this issue of Equine Veterinary Education , a case of central diabetes insipidus (DI) in a 20‐year‐old American Quarter Horse is presented (Moses et al . 2012).…”

“…In this issue of Equine Veterinary Education, a case of central diabetes insipidus (DI) in a 20-year-old American Quarter Horse is presented (Moses et al 2013). The diagnosis of DI was supported by a positive response to administered desmopressin acetate.…”