SummaryCentral diabetes insipidus (DI) was diagnosed in a 20-year-old American Quarter Horse gelding that was concomitantly affected with pituitary pars intermedia dysfunction (PPID). The diagnosis of DI was supported by a positive response to administered desmopressin acetate. Diagnosis of PPID was supported by physical appearance and elevated plasma adrenocorticotropic hormone concentration following domperidone administration. The horse's physical condition improved following treatment with pergolide but long-term treatment with desmopressin was not undertaken and severe polyuria and polydipsia persisted. Desmopressin acetate appears to be useful for the diagnosis of DI in mature horses concomitantly affected with PPID.

The c o n c l k i o n t h a t a high CHO d i e t r e s u l t s i n h y p e r t r i g l yceridemia has been based e n t i r e l y on F T r i g values. This study was designed t o evaluate the e f f e c t s o f v a r i a t i o n s i n CHO i n t a k e on T r i g IC as w e l l as F T r i . Four d i e t s were studied: 45% sucrose (A). 65% sucrose (83, 45% corn syrup (C). and 65% corn syrup (0). A l l d i e t s included 15% p r o t e i n and 300 mg. o f chol e s t e r o l . The e i g h t subjects consumed the constant l i q u i d d i e t s i n random order ( L a t i n square design) f o r 10 days p r i o r t o the 24 hour constant blood withdrawal study which provided the mean 24-.Hypercalciuria in children with diabetes mellitus.In our own control group of 58 healthy children the urinary calcium excretion (mglkg bodyweightl24hr) was for 56 children 2.4k1.4 (S.D.) and for 4 children more than 2 S.D. above the mean. In 15 out of the 47 diabetic children who were all receiving insulin therapy, the urinary excretion of calcium was 2 S.D. above the mean of the control group. The urinary calcium excretion (mglkgl24hr) correlated with the glucosuria: 2.1 + 0.9 urinary glucose (glkg124 hr); n-32, r-0.470, p less than 0.01. On the basis of this correlation the hvpercalciuria hour t r i g l y c e r i d e concentration-or Trig IC._ in 10 of the 15 hv~ercalciuric children could not-be attributed A term newborn girl with FGR (1616 gm) and phenotypic features of Leprechaunism had hyperglycemia and marked persistent hyperinsulinism (232-3000 uU/ml). After sudden death at 7 weeks. postmortem exam revealed findings nearly identical to those described by Donahue and Uchida (J. Pediatr. 45:505, 1954). Studies were undertaken to distinguish between an abnormal insulin and an abnormal cellular response to insulin. Evidence that the patient's immunoreactive insulin (IRI) behaved chemically and biologically like normal insulin is as follows:(l)By gel chromatography. 92% of the IRI migrated as insulin; 8% as proinsulin. (2)Serum IRI reacted normally with insulin receptors in human placental cell membranes.(3)Serum IRI was degraded at a normal rate by a crude preparation of insulin glucagon protease.(4)Serum insulin-like activity in a rat fat pad bioassay was proportional to serum IRI. The patient sppar6ntly had nonnal insulinl$gceptors, since her skin fibroblasts could specifically kind I insulin as well as those of newborn controls (2-7XIlx10 cells). On the other hand, preliminary studies indicate that the patient' fibroblasts had a significantly reduced capacity to incorporate %-thymidine in response to either insulin or serum. These results infer that the explanation for this patient's hyperinsulinism, insulin reaistance, and presumably FGR rests with a defective intracellular response to insulin an4possibly to other growth factors. Citrate complexing of Ca during neonatal "exchange" blood transfusions is associated with stimulation of PTH; theoretically P loading occurs from partially hemolyzed or P buffered blood. During exchange tra...