Antidopamine antibodies in the pathogenesis of parkinsonism

Chemical Exposures and Parkinson's Disease in Residents of Three Negev Kibbutzim

“…Provocation of autoimmune processes (Bokor et al, 1992;Kryzhanovskii et al, 1991;Wick et al, 1989;Weinberg et al, 1994;Yoshida and Gershwin, 1993) and creation of autoimmunity to structures of the dopaminergic system may be evoked by chemical similarity. This mechanism seems to us to be important for disease progression.…”

“…Damage to cytochrome P-450 (Agid, 1991;Ferrari et al, 1990) a 5. Autoimmune process (Kryzhanovskii et al, 1991) a 6. Depletion of neurotrophic factor (Hyman et al, 1991) 7.…”

Effect of active immunization with serotonin-protein conjugate on the development of experimental Parkinson's syndrome

“…Each series consisted of two groups: experimental and control. At the beginning of the experiments the rats were thrice tested for 4 rain in the open field for determination of the initial parameters of behavioral activity expressed as the integral behavioral index (IBI) [6]. In the successive open field tests the index of horizontal activity (ambulation) and IBI were expressed as a percentage of their initial level taken as 100%.…”

“…In rabbits antiserotonin antibodies injected in the striatum alleviate the symptoms of PS induced by 1-methyl-4-phenylpyridinium + (MPP +) but did not prevent death [6]. These data call for experimental verification on a standard PS model in rats under conditions of active production of antiserotonin antibodies.…”

“…Earlier we found that in rats parkinsonismlike syndrome (PS) may be induced by intrastriatal injection of antidopamine antibodies from the serum of both immunized rabbits and patients with Parkinson's disease [4,5]. In rabbits antiserotonin antibodies injected in the striatum alleviate the symptoms of PS induced by 1-methyl-4-phenylpyridinium + (MPP +) but did not prevent death [6].…”