Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Khongrum, Jurairat; Yingthongchai, Pratoomporn; Boonyapranai, Kongsak; Wongtanasarasin, Wachira; Donrung, Nowwapan; Sukketsiri, Wanida; Prachansuwan, Aree; Chonpathompikunlert, Pennapa

doi:10.1155/2022/4631983

Cited by 10 publications

(26 citation statements)

References 57 publications

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“…Outro composto citado é o maracujá (Passiflora edulis), uma fruta que possui em sua composição polifenóis, flavonóides, alcalóides, carotenóides e ácido ascórbico, os quais possuem efeitos antioxidantes, anti-hipertensivos, antitumorais, hipolipidêmicos e antiinflamatórios (KHONGRUM et al, 2022).…”

Section: Maki Et Al 2022unclassified

“…Em relação ao campo científico, não existem ainda relatos sobre a eficácia de uma combinação de extrato de cálice de rosela e componentes bioativos de maracujá em alimentos funcionais sobre a melhora do quadro de hipolipidemia. Diante disso, um estudo randomizado buscou avaliar os efeitos hipolipidêmicos, antioxidantes e anti-inflamatórios da bebida gelatinosa composta por extrato de cálices de rosela rico em polifenóis e suco de maracujá com polpa, sendo ingerida repetidamente durante 8 semanas entre adultos hiperlipidêmicos (KHONGRUM et al, 2022).…”

Section: Maki Et Al 2022unclassified

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Quais são as novas evidências para o manejo das dislipidemias? Uma revisão integrativa

Santana¹,

Freire²,

Netto³

et al. 2023

Braz. J. Hea. Rev.

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As dislipidemias se encontram difundidas amplamente na população brasileira, com uma prevalência de 24,8% e de até 75% em indivíduos obesos. O presente estudo de revisão buscou avaliar novos avanços para a abordagem terapêutica das dislipidemias, documentados por meio de estudos clínicos e randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos e testes controlados e randomizados; artigos publicados no último ano; que possuíam texto completo disponível e que abordassem acerca do manejo das dislipidemias. Ficou constatado que a terapia conjunta de pitavastatina e ezetimiba reduz, de forma significativa, os níveis de LDL-colesterol quando comparado com a monoterapia com pitavastatina, sem aumentar o número de eventos adversos gerais. Outra medida eficaz, ao se combinar a ezetimiba com a atorvastatina, houve uma maior eficácia na redução do nível de LDL-colesterol quando comparado com a monoterapia com atorvastatina. Além disso, observa-se o impacto positivo da suplementação de produto rico em polifenóis para a redução de lipídios no sangue, possibilitando um efeito protetor contra a aterosclerose, da mesma forma que a suplementação oral combinada de hidroxitirosol e punicalagina, a qual reduziu, de forma significativa, os níveis plasmáticos de LDL-colesterol e de triglicerídeos. Por fim, o uso do recaticimabe também pode ser aplicado como terapia adjuvante à estatina em indivíduos com hipercolesterolemia, reduzindo o nível de LDL-colesterol e tornando-se uma nova opção de tratamento segura e eficaz para o manejo de tal dislipidemia.

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Section: Maki Et Al 2022unclassified

Quais são as novas evidências para o manejo das dislipidemias? Uma revisão integrativa

Santana¹,

Freire²,

Netto³

et al. 2023

Braz. J. Hea. Rev.

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“…MDA, an oxidative marker of lipid peroxidation, correlates with the level of serum total cholesterol, triglyceride (TG), and LDL cholesterol [ 87 ], and extract leaves and calyces of roselle were proven to inhibit lipid peroxidation in vitro [ 76 ]. Moreover, atherosclerotic rabbit models that were fed delphinidin-3- O -glucoside from roselle in doses of 10 and 20 mg/kg for 12 weeks showed inhibited oxidative stress via the upregulation of GSH-PX and SOD1 mRNA levels [ 88 ].…”

Section: Roselle In the Attenuation Of Cardiovascular Diseases Risk F...mentioning

confidence: 99%

“…Previously, a study that was conducted by Asgary et al [ 105 ] in a double-blind placebo-controlled clinical trial showed that the daily consumption of 500 mg of roselle calyx powder for 4 weeks among forty adult patients with metabolic syndrome (hypertension, dyslipidemia, hyperglycemia) was able to significantly reduce serum TG and systolic blood pressure. Continuing with another randomized, double-blind, placebo-controlled trial, 300 mL of jelly drink containing polyphenol-rich roselle calyx extract given to forty-three adults with dyslipidemia for 8 weeks was demonstrated to decrease the levels of LDL-C, TG, TNFα, and MDA, and enhance the GSH level [ 87 ]. Hence, this study proved that roselle consumption could prevent CVD due to its polyphenolic content by exerting antioxidant and anti-inflammatory effects.…”

Section: Clinical Studiesmentioning

confidence: 99%

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors

Sapian,

Ibrahim Mze,

Jubaidi

et al. 2023

Pharmaceuticals

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Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart and blood vessels and remain a major cause of death and disability worldwide. CVD progression is strongly associated with risk factors, including hypertension, hyperglycemia, dyslipidemia, oxidative stress, inflammation, fibrosis, and apoptosis. These risk factors lead to oxidative damage that results in various cardiovascular complications including endothelial dysfunctions, alterations in vascular integrity, the formation of atherosclerosis, as well as incorrigible cardiac remodeling. The use of conventional pharmacological therapy is one of the current preventive measures to control the development of CVDs. However, as undesirable side effects from drug use have become a recent issue, alternative treatment from natural products is being sought in medicinal plants and is gaining interest. Roselle (Hibiscus sabdariffa Linn.) has been reported to contain various bioactive compounds that exert anti-hyperlipidemia, anti-hyperglycemia, anti-hypertension, antioxidative, anti-inflammation, and anti-fibrosis effects. These properties of roselle, especially from its calyx, have relevance to its therapeutic and cardiovascular protection effects in humans. This review summarizes the findings of recent preclinical and clinical studies on roselle as a prophylactic and therapeutic agent in attenuating cardiovascular risk factors and associated mechanisms.

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“…This compound is a powerful free radical scavenger with inhibiting glycation and scavenging activity against DPPH and superoxide anions thereby increasing antioxidant activity or reducing ROS to detoxify oxidative damage (Jin et al, 2022). Roselle can also be further studied as a pharmacological treatment to reduce risk factors for cardiovascular disease because it has been proven to have antihyperlipidemic, antihyperglycemic, antioxidant, antiinflammatory, antihypertensive, and antifibrosis properties (Ratna et al, 2018;Jamrozik, Borymska & Kaczmarczyk-Żebrowska, 2022;Khongrum et al, 2022;Sapian et al, 2023). Therefore, we want to relate and discuss in depth the potential use of Rosella in reducing oxidative stress and inflammation after physical activity through a systematic review.…”

Section: Introductionmentioning

confidence: 99%

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

Ayubi,

Padmasari,

Syafawi

et al. 2024

Teor. metod. fiz. vihov.

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Study purpose. This study aims to analyze and highlight the potential of rosella flowers in reducing oxidative stress and inflammation after physical activity. Materials and methods. The study used a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing Rosella Flowers, Oxidative Stress, Free Radicals, Inflammation, and Exercise. The exclusion criteria in this research were articles published in disreputable journals. A total of 357 articles from the Scopus, Web of Science Pubmed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) assessment. Results. The results of this systematic review research report that the flavonoid content found in rosella flowers has anti-oxidant and anti-inflammatory properties which have the potential to reduce oxidative stress and uncontrolled inflammation caused by physical activity and intense exercise. Conclusions. Rosella flowers show their ability as an anti-oxidative by donating hydrogen atoms to free radicals through phenolic compounds, thus breaking the cycle of ROS formation. The natural active ingredients in rosella flowers are able to reduce MDA and increase GSH which contributes to reducing oxidative stress and decreasing TNF-α which provides an anti-inflammatory effect in athletes after exercise.

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Antidyslipidemic, Antioxidant, and Anti-inflammatory Effects of Jelly Drink Containing Polyphenol-Rich Roselle Calyces Extract and Passion Fruit Juice with Pulp in Adults with Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 10 publications

References 57 publications

Quais são as novas evidências para o manejo das dislipidemias? Uma revisão integrativa

Quais são as novas evidências para o manejo das dislipidemias? Uma revisão integrativa

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

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