Antiendothelial cell antibodies in systemic lupus erythematosus

Renaudineau, Yves; Dugué, Christophe; Dueymes, Maryvonne; Youinou, Pierre

doi:10.1016/s1568-9972(02)00063-0

Cited by 76 publications

(58 citation statements)

References 28 publications

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“…The generation of autoAbs cross-reactive with endothelial cells is involved in several autoimmune vascular diseases [33][34][35] . Our studies [23,[36][37][38] showed that Abs directed against DV NS1 cross-reacted with endothelial cells and induced these cells to undergo nitric oxide-mediated apoptosis as well as cytokine and chemokine production.…”

Section: Discussionmentioning

confidence: 99%

C-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular Mimicry

Wan¹,

Lin²,

Chen³

et al. 2008

American J. of Infectious Diseases

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Infection with dengue virus (DV) causes diseases ranging from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia and bleeding are the clinical manifestations associated with dengue hemorrhage. We previously showed that anti-DV nonstructural protein 1 (NS1) antibodies (Abs) cross-reacted with endothelial cells. The potential target proteins on endothelial cell surface recognized by anti-DV NS1 Abs showed sequence homology with the C-terminal amino acids (a.a.) 311-352 of DV NS1. In this study, the role of NS1 C-terminal region in dengue autoimmunity was investigated. We deleted the a.a. 277-352 of DV NS1 to prepare truncated NS1 (tNS1) and generated anti-DV tNS1 Abs in mice. The endothelial cell-binding activity of anti-DV tNS1 Abs was lower than that of anti-DV NS1 Abs. In addition, the endothelial cell-binding activity of anti-DV NS1 Abs was inhibited by preabsorption with DV NS1 but not with DV tNS1 proteins. The anti-P311 (a.a. 311-330) and anti-P331 (a.a. 331-350) titers of dengue patient sera were positively correlated with their endothelial cell-binding activity. Dengue patient sera showed lower binding activity to DV tNS1 than to DV NS1 proteins. The endothelial cell-binding activity of dengue patient sera was inhibited by preabsorption with P311 and P331. This study helps to understand the molecular mechanisms of autoimmunity mediated by anti-DV NS1 Abs and to provide the potential implications of tNS1 in dengue vaccine strategies.

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Section: Discussionmentioning

confidence: 99%

C-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular Mimicry

Wan¹,

Lin²,

Chen³

et al. 2008

American J. of Infectious Diseases

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“…It is possible that endothelial apoptosis, secondary to autoimmune injury, could initiate dysfunctional endothelial cell proliferation that culminates in PAH in the same manner that endothelial apoptosis, induced by vascular endothelial growth factor antagonism, results in endothelial cell proliferation and PAH [67]. Anti-endothelial antibodies are present in autoimmune disorders associated with PAH including systemic lupus erythematosus [68], mixed connective tissue disease [69] and scleroderma [38]. In lupus and Sjö gren's syndrome, antibody and complement deposits are localised in the walls of pulmonary arteries of patients with PAH [70,71].…”

Section: Autoreactive B-cell Activation In the Absence Of T-cell Regumentioning

confidence: 99%

Autoimmunity and pulmonary hypertension: a perspective

Nicolls¹

2005

Eur Respir J

239

185

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The association between autoimmunity and pulmonary arterial hypertension (PAH) has been appreciated for .40 yrs, but how autoimmune injury might contribute to the pathogenesis of this disease has only been examined in a case-specific manner.It is becoming increasingly clear that a variety of diverse clinical diseases, ranging from viral infections to connective tissue disorders, can culminate in pulmonary vascular pathology that is indistinguishable. Is there a hitherto unappreciated biology that unites these seemingly unrelated conditions?The answer to this question may come from the increasing body of evidence concerned with the central importance of regulatory T-cells in preventing inappropriate B-cell activity. Two striking similarities between conditions associated with severe angioproliferative pulmonary hypertension are a defect in the CD4 T-cell compartment and auto-antibody production. Pathogenic autoantibodies targeting endothelial cells are capable of inducing vascular endothelial apoptosis and may initiate the development of PAH.The present review will focus on what is known about autoimmune phenomena in pulmonary arterial hypertension patients, in order to better consider whether an early loss of self-tolerance followed by autoimmune injury could influence the early development of severe angioproliferative pulmonary hypertension.

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“…Notably, inflammation in the perivascular space includes accumulation of mast cells and lymphocytes (11,14,15). Given the association of autoimmune phenomena with SPH, such as detection of anti-nuclear and anti-endothelial cell antibodies (16)(17)(18)(19)(20)(21), the finding of antibody-complement deposits in the lungs of patients with SPH (22,23), and the presence of inflammatory cells around plexiform lesions in SPH, there appears to be a basis for an immune-mediated component in SPH pathogenesis. We sought to specifically address the contribution of T cells to the development of SPH.…”

mentioning

confidence: 99%

Absence of T Cells Confers Increased Pulmonary Arterial Hypertension and Vascular Remodeling

Taraseviciene‐Stewart¹,

Nicolls²,

Kraskauskas³

et al. 2007

Am J Respir Crit Care Med

162

135

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Rationale: Severe pulmonary arterial hypertension (SPH) is a frequently lethal condition characterized by pulmonary vascular remodeling and right heart strain or failure. SPH is also often associated with autoimmune and collagen vascular disorders. Objectives: To study the effects of T cells on the development of experimental SPH. Conclusions: These studies demonstrate the importance of a complete, intact immune system in protecting against pulmonary angioproliferation in this new model of SPH as well as the importance of intact VEGF receptor signaling for lung endothelial cell homeostasis.

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Antiendothelial cell antibodies in systemic lupus erythematosus

Cited by 76 publications

References 28 publications

C-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular Mimicry

C-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular Mimicry

Autoimmunity and pulmonary hypertension: a perspective

Absence of T Cells Confers Increased Pulmonary Arterial Hypertension and Vascular Remodeling

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