Antiendothelial Cell Antibodies: Useful Markers of Systemic Sclerosis

The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis.

“…Importantly, only some of the patients with SS had the PS exposure-inducing subset of AECA. These autoAb might be useful markers of the disease, since the six positive SS patients had been classified previously as having a diffuse form of the disease, while the two negative patients had a limited form of the same disorder (7). However, the accelerated apoptosis was not absolutely specific for SS.…”

Detection of Antiendothelial Cell Antibodies by an Enzyme-Linked Immunosorbent Assay Using Antigens from Cell Lysate: Minimal Interference with Antinuclear Antibodies and Rheumatoid Factors

“…This is of particular interest when samples from patients with systemic sclerosis or lupus erythematosus are assayed for AECAs. Indeed, in patients with such systemic disorders, ANAs are frequently found at high titers and AECAs may contribute or may be associated with the pathogenesis and the activity of the disease (3,10,20). The experimental procedure that we retained to circumvent the problem of false-positive results due to ANAs and to properly detect associated genuine AECAs was to discard the nucleus from the PNS antigen preparation.…”

Autoantibodies in Systemic Sclerosis: Spectrum, Clinical Associations, and Prognostic Value

“…Известно, что при ССД циркуляция АЭАТ ассоци-ируется с выраженными сосудистыми нарушениями -тя-желым синдромом Рейно, дигитальными рубчиками и яз-вами, легочной гипертензией, а также с легочным фибро-зом. Высокие титры АЭАТ ассоциировались с тяжелой микроангиопатией по данным капилляроскопии [98][99][100][101]. Полагают, что после связывания аутоАТ с по-верхностью эндотелия начинаются процессы активации микрососудистых эндотелиальных клеток и, возможно, развитие антителозависимой клеточно-опосредованной цитотоксичности [102].…”