Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy

Abstract

IMPORTANCE Limited population-based data are available on antiepileptic drug (AED) treatment patterns in women of childbearing age with epilepsy; the current population risk is not clear. OBJECTIVES To examine the AED treatment patterns and identify differences in use of valproate sodium and topiramate by comorbidities among women of childbearing age with epilepsy. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study used a nationwide commercial database and supplemental Medicare as well as Medicaid insurance claims data to identify 46 767 women with epilepsy aged 15 to 44 years. The eligible study cohort was enrolled between

Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy

“…According to incomplete statistics, about 0.3-0.7% of women of childbearing age in the world have epilepsy during pregnancy and 0.3-0.5% of children come from women with epilepsy [13][14][15]. In all patients with epilepsy during pregnancy, the proportion of patients who choose to receive AEDs monotherapy can be as high as 98.6% [16]. Among them, the commonly used AEDs are traditional AEDs such as sodium valproate, carbamazepine, and new AEDs such as lamotrigine, levetiracetam, and oxcarbazepine.…”

Optimal choice of antiseizure medication: Agreement among experts and validation of a web‐based decision support application

“…Choosing an optimal ASM is not an exact science and requires training and extensive experience, which may not always be available. Suboptimal ASM selection is common, at least in some settings, and may cause harm 6‐11 . Whether experts weigh critical factors in a similar way is not known, and inter‐rater agreement in selecting currently available ASMs for individuals with a wide range of clinical variables has not been investigated before.…”

Antiepileptic Drugs Cause Lethal, Sublethal, Teratogenic Effects and Morphometric Parameters on Embryos and Larvae of Zebrafish (Danio Rerio)

“…Os efeitos teratogênicos revelaram malformação da cabeça INTRODUCTION Antiepileptic drugs are among the most common teratogenic drugs prescribed to women of childbearing age (Shihmanab, et al, 2019;Li et al, 2020). Approximately 1 million women of childbearing age have epilepsy, being important to highlight that the continued use of antiepileptic drugs is recommended to reduce the maternal and fetal trauma associated with seizures in the USA (Patel and Pennell, 2016;Kim et al, 2019;Cho et al, 2020). However, prenatal exposure to antiepileptic drugs can cause growth retardation, major congenital malformations, and intelligence deficits in the developing fetus (Kim et al, 2019;Patel and Pennell, 2016;Bhakta et al, 2015).…”

“…Approximately 1 million women of childbearing age have epilepsy, being important to highlight that the continued use of antiepileptic drugs is recommended to reduce the maternal and fetal trauma associated with seizures in the USA (Patel and Pennell, 2016;Kim et al, 2019;Cho et al, 2020). However, prenatal exposure to antiepileptic drugs can cause growth retardation, major congenital malformations, and intelligence deficits in the developing fetus (Kim et al, 2019;Patel and Pennell, 2016;Bhakta et al, 2015). The estimated prevalence of major congenital malformations, such as facial clefts, hypospadias, cardiac defects, and neural tube defects, in the children of epileptic women, is 4-10 %, which represents a two-to fourfold increase compared to the general population (Bhakta et al, 2015).…”