Antiestrogenic activity of lead

Tchernitchin, N. N.; Villagra, A.; Tchernitchin, Andrei N.

doi:10.1002/(sici)1098-2256(1998)13:1<43::aid-tox2>3.0.co;2-7

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…For metals like cadmium and lead that have no biological function, this calls for public concern [26] [27]. The elevated levels of these metals in the soil profiles constitute a serious threat to both surface and ground water.…”

Section: Heavy Metal Distributionmentioning

confidence: 99%

An Assessment of Heavy-Metal Contamination in Soils within Auto-Mechanic Workshops Using Enrichment and Contamination Factors with Geoaccumulation Indexes

Ololade¹

2014

JEP

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Soil characterization and heavy metals in different layers (0 -15 cm; 15 -30 cm and 30 -45 cm depth) of automobile mechanic waste dumps were studied. The soils showed remarkably high levels of all the metals above background concentrations with most (Ni, Cu, Fe, Cr and Cd) decreasing with soil depth. The distribution pattern were in the following order Fe > Cu > Zn > Pb > Cr > Ni > Cd. Across all the sampling locations and profiles, Fe and Cd showed the highest (476.4 μg·g −1 ) and least (37.5 μg·g −1 ) mean concentrations respectively. Pollution load index (PLI) and index of geoaccumulation (Igeo) revealed overall high and moderate contamination respectively but the enrichment factors (EFs) for Pb Ni and Cd are severe. The inter-element relationship revealed the identical source of elements in the soils of the studied area. The accuracy of the results has been cheeked using the standard reference material; SRM (PACS-2). The mechanic waste dumps represent potential sources of heavy metal pollution to environment. The elevated levels of heavy metals in these soil profiles constitute a serious threat to both surface and groundwater.

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Section: Heavy Metal Distributionmentioning

confidence: 99%

An Assessment of Heavy-Metal Contamination in Soils within Auto-Mechanic Workshops Using Enrichment and Contamination Factors with Geoaccumulation Indexes

Ololade¹

2014

JEP

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“…Cadmium and lead are not required even in small amounts by living organisms (Techernitchin et al 1998;Naqvi and Howell 1993). However, other heavy metals are potentially harmful to most organisms at some level of exposure and absorption (Chan et al 1999;Candi and Furness 1993).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the exposure of two fish species to metals pollution in the Ogun river catchments, Ketu, Lagos, Nigeria

Adeniyi

Yusuf

Okedeyi

2007

Environ Monit Assess

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The concentrations of metals (Ca, Cd, Fe, Mn, Pb and Zn) were determined by flame atomic absorption spectrophotometry in water, sediments and fish samples in the Ogun river catchments, Ketu, Lagos, which is an important bird nesting, fishing and drinking water source. The results show that the southern tip bothering the Lagos lagoon is where the highest metal concentrations are found in the fish species (Tilapia sp. and Chrysichthys sp.), whereas the Agboyi creek segment near the lagoon with higher surrounding human population density recorded higher levels of metals in sediments and water samples. The two fish species accumulated different amounts of metals. However, the differences were not statistically different at p < 0.05. There is a significant correlation (p < 0.05) for Cd concentration in water. The concentrations of Pb in sampling points 3 and 4 as well as Cd, Mn and Fe in all six sampling points exceeds the World Health Organization (WHO) limits for drinking water. Levels of metals obtained for sediments are within the range reported for Nigeria's river sediments. Based on this study, the human risks for heavy metals in the harvested fish species from the Ogun river catchments, Ketu, are low for now as the concentrations were below the recommended Food and Agriculture Organization (FAO) maximum limits for Pb (0.5 mg/Kg), Cd (0.5 mg/Kg), and Zn (30 mg/Kg) in fish.

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“…Las disimilitudes entre los efectos de la exposición aguda a cadmio, con aquellos de una exposición a plomo 33 , sugieren diferencias en los mecanismos involucrados. El plomo inhibe la eosinofilia uterina inducida por E 33 ; en cambio el Cd potencia dicha respuesta hormonal.…”

Section: Discussionunclassified

“…El plomo inhibe la eosinofilia uterina inducida por E 33 ; en cambio el Cd potencia dicha respuesta hormonal. El plomo antagoniza totalmente la hipertrofia celular inducida por E en miometrio circular 33 , en cambio el Cd sólo la inhibe levemente. Esto puede sugerir que algunos de los mecanismos involucrados en las toxicidad de ambos metales en útero no sean los mismos.…”

Section: Discussionunclassified

“…La eosinofilia uterina fue evaluada por recuento en 30 cortes transversales de útero por animal 23,31 ; el edema del endometrio profundo fue evaluado por morfometría en 36 áreas en 12 cortes transversales de útero 31 ; la hipertrofia miometrial fue evaluada por morfometría en 36 áreas en 12 cortes transversales de úte-ro 31,32 , y la respuesta proliferativa fue evaluada por recuento de figuras mitóticas en 24 cortes de útero en cada capa histológica uterina por separado y expresada como número de mitosis por corte de útero 32 . Los resultados fueron expresados como % de la respuesta obtenida con E en ratas controles, valor que fue definido como 100% de respuesta, y definiendo el valor obtenido en los controles como 0% de respuesta, pudiendo existir valores negativos cuando las mediciones reflejaron valores inferiores a los del control 33 . Análisis Estadístico: Para realizar comparaciones múltiples entre las condiciones experimentales, los datos fueron sometidos al test de la mínima diferencia significativa (LSD).…”

Section: Materials Y Métodosunclassified

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Efectos de exposición aguda a cadmio en la acción de estrógenos en útero de rata impúber

Tchernitchin

Olivares

Aranda

et al. 2008

Rev. chil. pediatr.

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Antiestrogenic activity of lead

Cited by 14 publications

References 28 publications

An Assessment of Heavy-Metal Contamination in Soils within Auto-Mechanic Workshops Using Enrichment and Contamination Factors with Geoaccumulation Indexes

An Assessment of Heavy-Metal Contamination in Soils within Auto-Mechanic Workshops Using Enrichment and Contamination Factors with Geoaccumulation Indexes

Assessment of the exposure of two fish species to metals pollution in the Ogun river catchments, Ketu, Lagos, Nigeria

Efectos de exposición aguda a cadmio en la acción de estrógenos en útero de rata impúber

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