Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines

Abstract

The present study deals with a brief description of antifertility and antimicrobial aspects along with the spectral characterization of lead(IV) complexes. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs of an interesting class of biologically potent complexes on male albino rats at the dosages have been examined and discussed. Lead(IV) complexes have been synthesized using amino acids and 1,10-phenanthroline, 4,7-phenanthroline or 1,7-phenanthroline. A series of di-and tri-organolead(IV) [LPbR n L ] and [LPbClR n L ] complexes where, L = amino acid (tyrosine and phenylalanine) and L = 1, 10-phenanthroline, 4,7-phenanthroline or 1,7-phenanthroline and n = 2 or 3 have been prepared by the conventional methods. Structure elucidation has been done by IR, UV, 1 H, 13 C and 207 Pb NMR spectroscopy. On the basis of spectral evidences, it has been concluded that the carboxylic acid of the amino acid is behaving as a monodentate ligand in all these complexes and the complexes are octahedral in shape with a coordination number six around the lead atom. The complexes have been screened against a number of fungi and bacteria to assess their growth inhibiting potential. Lead complexes incorporating the chelating 1,10-phenanthroline ligand showed a range of activities. The metal free non-chelating ligands 1,7-phenanthroline and 4,7-phenanthroline were inactive and the complexes derived from 1,7-phenanthroline displayed only marginal activity.

Synthesis, spectroscopic characterization, and 3D molecular modeling of lead(II) complexes of unsymmetrical tetradentate Schiff-base ligands

“…This is supported by upward shift in m(C-N) to the extent of 10-30 cm -1 . The FTIR spectra of metal chelates contained new bands in the 530-542 cm -1 range, assigned to (Pb / N), and in the 455-470 cm -1 range, assigned to (Pb-O) [34,35]. The disappearance of a band due to m(C=O) and appearance of new bands at 1550-1570 and 1365-1370 cm -1 assignable to m(NCO -) [36] are indicative of deprotonation of the NH proton and bonding through the imidolate oxygen.…”

Microwave‐assisted synthesis, characterization, biotoxicity and antispermatogenic activity of some antimony(III) complexes with N∩O and N∩S donor ligands

“…The LD 50 (Table 4) is statistically derived single dose of a substance that can be expected to cause death in 50% of the animals. [45] In a prohibited analysis method of LD 50 , the selected dose levels should bracket the expected LD 50 value with at least one dose level higher than the expected LD 50 but not causing 100% mortality and one dose level below the expected LD 50 but not causing 0% mortality. Toxicity of the complexes was determined by calculating the LD 50 values.…”

Acaciaside-B-enriched fraction of Acacia auriculiformis is a prospective spermicide with no mutagenic property

“…So the development of a suitable alternative is an urgent global need. Many novel compounds that have antifertility and possible antimicrobial effects are currently being developed and tested (Chaudhary et al 2007). However, substantial challenges remain before a new contraceptive microbicide product will be available for distribution.…”