Scale inhibitors are effective in preventing CaCO 3 scaling in geothermal systems, but the scale inhibition performance and price of commercial scale inhibitors in high-temperature and high-salinity water are still not ideal. In this work, a novel modified carboxymethylated β-cyclodextrin tetrameric (CAAS) scale inhibitor was synthesized using carboxymethylated β-cyclodextrin, acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid (AMPS), and p-styrenesulfonate (SSS) by free radical polymerization, and deprotonated CAAS (D-CAAS) was prepared based on CAAS. The results of the static test showed that the CaCO 3 scale inhibition efficiency of D-CAAS reached 90.8% at 100 C and 800 mg/L Ca 2+ . Compared with that of previous commercial scale inhibitors, the scale inhibition efficiency of D-CAAS was increased by 13.5%, and the price can be decreased by 26.1%. The results of SEM, XRD and molecular dynamics (MD) simulation showed that at 100 C-120 C, the deprotonation of D-CAAS enhanced the weak interaction between D-CAAS and CaCO 3 , inducing the transformation between calcite and vaterite and forming a loose scale. Deprotonation weakens the hydrogen bond between D-CAAS and water to reduce the energy required for the binding of D-CAAS to the surface of CaCO 3 . This study is expected to provide a low-cost and high-efficiency CaCO 3 scale inhibitor for geothermal applications.