Antifungal activities of medicinal plants extracts of Ivorian pharmacopoeia

Abstract

Aim:This study was to evaluate in vitro anti-fungal activity of aqueous and hydroethanolic from medicinal plants extracts collected in Côte d’Ivoire.Materials and Methods:Plants extracts were prepared by homogenization and separately incorporated to Sabouraud agar using the agar slanted double dilution method. Ketoconazole was used as standards for anti-fungal assay. The anti-fungal tests were performed by sowing 1000 cells of Candida albicans on the previously prepared medium culture. Anti-fungal activity was determined by evaluating anti-fungal parameters values (minimal fungicidal concentrations [MFC] and IC50).Results:The results showed that all extracts possessed anti-fungal activities whose levels vary from plant species to another. Eight of them had a satisfactory anti-candidosic activity and extracts from Terminalia species were the most active. Among them the Terminalia superba extracts generated the strongest activities (MFC = 0.0975 mg/mL). Compared with ketoconazole (MFC = 0.390 mg/mL), the T. superba extracts, aqueous (MFC = 0.195 mg/mL) and hydroethanolic (0.0975 mg/mL) were successively twice and four times more active. The worst anti-fungal activity (MFC = 1600 mg/mL) was obtained with the Guarea cedrata aqueous extract.Conclusion:All medicinal plants extracts produced anti-fungal activities, and T. superba was the most active.

Evaluation of Ointment Activity Based on Terminalia Mantaly Extract

“…On the other hand, the qualities of the obtained ointment are similar to those obtained by 40 Rokia et al,(2006) by its consistence, its pH (5.5) and its perfect homogeneity. However, the very strong anticandidosic activity of TEKAM 1 -X 0 has already been reported by Kra et al, (2014 and2015) and 21 Yayé et al, (2012) who worked in similar conditions with T mantaly barks. However the comparison of extract's performances reveals that TEKAM 1 -X 0 from the present study is respectively 2 times and 21.92 times more active than the extracts prepared by these authors.…”

“…According to the classification scale of the levels of the activities of 24 Kra et al,(2014), TEPOM, TEKAM 1 -X 0 and Kétoconazole anti-fungal activities are classified as very high levels of activity. The anticandidosic activity of SB is very low.…”

“…In Côte d'ivoire,this plant is used against gastroenteritidis, oral affections, skin disorders, genital candidiasis, arterial high blood pressure and diabetes ( 19 Riviere et al, 2005, 20 Yayé et al, 2012). Otherwise, recent works proved that T. mantaly possesses excellent antibacterial and antifungal activities ( 15 Kueté et al, 2010;21-22 Yayé et al, 2011 et 2012; 23 Ackah et al, 2014; 24 Kra et al, 2014). For better appreciation of the use of T mantaly in human therapeutics, the present study was initiated to evaluate and compare the anticandidosic activities of the crude hydroethanolic extract of T. mantaly and to those of the ointment formulated from this extract.…”

A complex game of hide and seek: the search for new antifungals

“…One study tested the extracts of multiple parts of plants found in the pharmacopoeia of the Côte D’Ivoire. 112 While no individual plants were identified or compounds characterized, C. albicans spp. were found to be sensitive to all the extracts tested.…”

Anticandidosic activity of selected medicinal plants from Cte dIvoire

“…(Tine et al, 2017) and many other herbs have also been reported. Indeed, Kra Mathieu et al showed that the hydroethanolic extracts from the four Terminalia species produced minimal fungicidal concentrations (MFC) values that are lower than the MFC value of ketoconazole (Mathieu et al, 2014). Other plant species like Borreria latifolia, Borreria verticillata, Erigeron floribundus, Euphorbia hirta, Turraea heterophylla and Vernonia colorata were tested (Bi et al, 2007).…”