2011
DOI: 10.4314/ajtcam.v8i3.65300
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Antifungal activity and acute toxicity of stem bark extracts of <i>Drypetes Gossweileri</i> S. Moore-Euphorbiaceae from Cameroon

Abstract: Drypetes gossweilleri S. Moore is a plant used in traditional medicine in Cameroon. The antifungal properties of its stem-bark crude extract and fractions DG(1), DG(2), DG(3), DG(4), DG(5), DG(6), DG(7), DG(8) and DG(9) were assayed by agar and broth dilution methods on solid and liquid media against C. Krusei, C. albicans, C. glabrata, T. mentagerophytes, M. langeroinii, M. gypeum, M. audouini, T. rubrum, T. soudanense, T. terrestre, A. flavus and A. niger. The results revealed a substantial antifungal effect… Show more

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Cited by 7 publications
(9 citation statements)
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“…S1 b and S2). A preliminary phytochemical screening on the active extracts highlighted the presence of polyphenols, flavonoids and triterpenoids, in accordance with the chemical composition reported for other related species (Ngouana et al, 2011;Ng'ang'a et al, 2011¸Wandji et al 2003. The comparison between the HPLC fingerprint of the traditional preparation (WE) and the DME, allowed to identify some common zones in the chromatogram profiles (Fig.…”
supporting
confidence: 83%
“…S1 b and S2). A preliminary phytochemical screening on the active extracts highlighted the presence of polyphenols, flavonoids and triterpenoids, in accordance with the chemical composition reported for other related species (Ngouana et al, 2011;Ng'ang'a et al, 2011¸Wandji et al 2003. The comparison between the HPLC fingerprint of the traditional preparation (WE) and the DME, allowed to identify some common zones in the chromatogram profiles (Fig.…”
supporting
confidence: 83%
“…Fraction FD displayed no antifungal activity. The differential distribution of bioactivity among the fractions might be explained by the proportions of different bioactive components of each fraction, acting either in a synergetic or in potentiating way [44]. Since FA showed the strongest inhibition of mycelial growth, we chose it for further analytical studies.…”
Section: Discussionmentioning
confidence: 99%
“…Morphological examination of various organs and fluctuations in their relative weights revealed no differences between control groups (treated with distilled water or maize oil) and treated rats (Ngouana et al, 2010). Moreover, no toxic effect was noticed in male and female albino Wistar rats treated per os with the crude stem bark extract at a dose up to 12 g/kg of body weight (Ngouana et al, 2011).…”
Section: Toxicitymentioning
confidence: 92%
“…The antifungal properties of the DCM-MeOH ( (Ngouana, 2011). From the MeOH extract of the stem bark, the isolated -amyrone 43 and N-β-glucopyranosyl-p-hydroxyphenylacetamide 117, exhibiting activity against C. albicans with MIC 16 µg/mL and 8.0 μg/mL, respectively (Ata et al, 2011).…”
Section: Antifungal Activitymentioning
confidence: 99%
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