Antifungal activity of Myrtus communis against Malassezia sp. isolated from the skin of patients with pityriasis versicolor

Barać, Aleksandra; Donadu, Matthew Gavino; Usai, Donatella; Spirić, Vesna Tomić; Mazzarello, Vittorio; Zanetti, Stefania Anna Lucia; Aleksic, Ema; Stevanović, Goran; Nikolić, Nataša; Rubino, Salvatore

doi:10.1007/s15010-017-1102-4

Cited by 36 publications

(18 citation statements)

References 10 publications

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“…These mechanisms have been described in isolates of C. albicans , C. neoformans , and Malassezia sp. [ 35 , 36 ]. The intrinsic resistance to azole antifungals in C. albicans seems to be due precisely to a reduced susceptibility of the target enzyme.…”

Section: Discussionmentioning

confidence: 99%

Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Donadu

Peralta-Ruiz

Usai

et al. 2021

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Drug resistance in antifungal therapy, a problem unknown until a few years ago, is increasingly assuming importance especially in immunosuppressed patients and patients receiving chemotherapy and radiotherapy. In the past years, the use of essential oils as an approach to improve the effectiveness of antifungal agents and to reduce antifungal resistance levels has been proposed. Our research aimed to evaluate the antifungal activity of Colombian rue, Ruta graveolens, essential oil (REO) against clinical strains of Candida albicans, Candida parapsilopsis, Candida glabrata, and Candida tropicalis. Data obtained showed that C. tropicalis and C. albicans were the most sensitive strains showing minimum inhibitory concentrations (MIC) of 4.1 and 8.2 µg/mL of REO. Time–kill kinetics assay demonstrated that REO showed a fungicidal effect against C. tropicalis and a fungistatic effect against C. albicans. In addition, an amount of 40% of the biofilm formed by C. albicans was eradicated using 8.2 µg/mL of REO after 1 h of exposure. The synergistic effect of REO together with some antifungal compounds was also investigated. Fractional inhibitory concentration index (FICI) showed synergic effects of REO combined with amphotericin B. REO Lead a disruption in the cellular membrane integrity, consequently resulting in increased intracellular leakage of the macromolecules, thus confirming that the plasma membrane is a target of the mode of action of REO against C. albicans and C. tropicalis.

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Section: Discussionmentioning

confidence: 99%

Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Donadu

Peralta-Ruiz

Usai

et al. 2021

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“…Some clinical isolates of Candida species have been resistant against fluconazole and other triazole antifungal drugs. Therefore, the demand for newly effective antifungals is urgently required [40][41][42]. Natural products have long been known as key therapeutic agents providing many potent bioactivities while exhibiting high safety profiles.…”

Section: Discussionmentioning

confidence: 99%

Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam

Donadu

et al. 2020

J Infect Dev Ctries

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Introduction: The present study aimed to determine the chemical compositions and bioactivities of the essential oil of Atalantia sessiflora Guillaumin (A. sessiflora), including antibacterial, antimycotic, antitrichomonas, anti-inflammatory and antiviral effects. Methodology: The essential oil from leaves of A. sessiflora was extracted by hydrodistillation using a Clevenger apparatus. Chemical compositions of oil were identified by GC/MS. Antimicrobial and antitrichomonas activity were determined by the microdilution method; anti-inflammatory and antiviral were determined by the MTT method. Results: The average yield of oil was 0.46 ± 0.01% (v/w, dry leaves). A number of 45 constituents were identified by GC/MS. The essential oil comprised four main components. The oil showed antimicrobial activities against Gram-positive strains as Staphylococcus; Gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli; and finally four Candida species. Enterococcus faecalis and Pseudomonas aeruginosa were least susceptible to the oil of A. sessiflora, as seen in their MIC and MLC values over 16% (v/v). Activity against Trichomonas vaginalis was also undertaken, showing IC50, IC90 and MLC values of 0.016, 0.03 and 0.06% (v/v) respectively, after 48 hours of incubation. The oil of A. sessiflora displayed activity against the nitric oxide generation with the IC50 of 95.94 ± 6.18 µg/mL. The oil was completely ineffective against tested viruses, ssRNA+, ssRNA-, dsRNA, and dsDNA viruses. Conclusions: This is the first yet comprehensive scientific report about the chemical compositions and pharmacological properties of the essential oil of A. sessiflora. Further studies should be done to evaluate the safety and toxicity of A. sessiflora oil.

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“…isolated from the skin of patients with pityriasis versicolor. The results showed the antimicrobial activity of M. communis essential oil against of Malassezia (16).…”

Section: Discussionmentioning

confidence: 95%

Evaluation of the Antibacterial Effect of Ethanol and Ethyl Acetate Extracts of Myrtus communis Against Antibiotic-Resistant Pseudomonas aeruginosa

et al. 2019

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Background: Pseudomonas aeruginosa is a human and plant pathogen. The aim of this study was to investigate the antibacterial effects of ethanol and ethyl acetate extracts of Myrtus communis against antibiotic-resistant P. aeruginosa isolates. Methods: The plant was collected from the plains of Kerman province, and its ethanol and ethyl acetate extracts were prepared using a rotary machine. Pseudomonas aeruginosa strains were isolated from urine and blood samples of patients in Zabol, Iran. Antibiotic resistance pattern was determined by the agar diffusion method. Finally, the minimum inhibitory concentration (MIC) and minimum trace concentration (MTC) were determined by the microdilution method. Results: The antibiotic-resistance patterns of the standard and clinical strains showed that P. aeruginosa was resistant to all antibiotics at the following rates: Azithromycin (25%), ampicillin (12.5%), gentamycin (0%), amoxi-clav (12.5%), cefazolin (12%), and amikacin (12.5%). The study of the effect of ethanol extract on clinical and standard P. aeruginosa strains showed that the MIC of the ethanolic extract against the standard strain of P. aeruginosa was 25 ppm. Conclusions: The results of this study showed good antimicrobial effects of the plant extracts against antibiotic-resistant P. aeruginosa, which can be used to treat Pseudomonas infections.

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Antifungal activity of Myrtus communis against Malassezia sp. isolated from the skin of patients with pityriasis versicolor

Cited by 36 publications

References 10 publications

Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam

Evaluation of the Antibacterial Effect of Ethanol and Ethyl Acetate Extracts of Myrtus communis Against Antibiotic-Resistant Pseudomonas aeruginosa

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