Antifungal agents. 1. Synthesis and antifungal activities of estrogen-like imidazole and triazole derivatives

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(α-azolylbenzyl)-1H-indoles as selective aromatase inhibitors

“…The synthesis of imidazolyl-substituted compounds 11 -14 was achieved by the direct reaction of the carbinols 7 -10 with 1,1 0 -carbonyldiimidazole (CDI) in THF [39], via decarboxylation of the carbamate intermediate. The triazolyl-substituted compounds 15 -18 were prepared by the direct reaction of the corresponding carbinols with sulfinylditriazole (SDT) [40], which was readily generated from triazole and SOCl 2 in acetonitrile.…”

Stereoselective Synthesis and in Vitro Antifungal Evaluation of (E)- and (Z)-Imidazolylchromanone Oxime Ethers

“…Further progressive double dilutions with test medium gave the required concentrations of 64, 32, 16, 8, 4, 2, 1, 0.5, 0.25, and 0.013 µg/mL. The minimum inhibitory concentration (MIC) was determined by using the method of two-fold serial dilution technique [19]. All compounds were tested for their in vitro growth inhibitory activity against Candida albicans, Aspergillus niger, and Microsporum gypseum.…”

Synthesis of new heterocyclic compounds having 1,2,3‐triazole and isoxazole rings in a single molecule

“…Generally, triazole derivatives have been synthesized as possible antidepressants and plant growth regulators [1][2][3]. Some of the 1,2,4-triazole derivatives have anti-inflammatory activities and some are antifungal agents or herbicides [4][5][6]. Isoxazole derivatives form a part of many drugs used for antidepressant therapy and the treatment of osteoarthritis or rheumatoid arthritis [7,8].…”