Antifungal and antibacterial effects of 1‐monocaprylin on textile materials

Vltavská, Pavlína; Kašpárková, Věra; Janiš, Rahula; Buňková, Leona

doi:10.1002/ejlt.201100229

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…In general, fatty acid monoglycerides have broad antibacterial spectrum and stable inhibitory activity, which are often used to control foodborne pathogens according to some previous reports (17, 20, 21, 27, 45, 46). They offer a preliminary view on antimicrobial performance of individual monoglyceride in medium or food ingredients.…”

Section: Discussionmentioning

confidence: 99%

The key lethal effect existed in the antibacterial behavior of short, medium, and long chain fatty acid monoglycerides onEscherichia coli

Song

Xiong

Lou

et al. 2018

Preprint

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Monoglyceride is an amphiphilic molecule with promising antimicrobial 22 activity for bacteria; however, the key lethal effect in its antibacterial behavior was still 23 unknown. In the study, monobutyrate (MB), monolaurate (ML), monomyristate (MM) 24 were selected to represent the short, medium, and long chain monoglycerides to compare 25 their inhibitory effect against Escherichia coli, and a new dose-dependent inhibitory 26 mechanism was proposed by the key lethal effect. The minimal inhibitory concentration 27 and antibacterial curve showed a huge diversity existed in biology activity of MB, ML 28 and MM. The results in scanning electron microscopy and flow cytometry assay 29 indicated that the interference level of MB on cell membrane was obviously weaker than 30 that of ML and MM, while the latter two had similar performance in increasing cell 31 permeability at low doses. The results presented in UV-Vis spectroscopy, cell cycle and 32 biomacromolecules synthesis inhibition assay showed that the cell cycle of Escherichia 33 coli was obviously affected by three monoglycerides at doses near MIC, which was 34 therefore regarded as the key lethal effect. The reason for the better biological activity of 35 MM than ML was the stronger interference ability on bacterial cell cycle. In addition, an 36 expanded antibacterial mode was raised that cell permeability increase at low doses was 37 antimicrobial basis, cell cycle arrest at medium doses played the key lethal effect, and 38 cell lysis at high doses was the result of combined action. 39 40

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Section: Discussionmentioning

confidence: 99%

The key lethal effect existed in the antibacterial behavior of short, medium, and long chain fatty acid monoglycerides onEscherichia coli

Song

Xiong

Lou

et al. 2018

Preprint

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“…The activity was less important for C. krusei, which often demonstrates an intrinsic resistance to azole drugs [31]. [12,13] (Table 3). In these latter tests, the activity of ECN reached 62% of the commercial formulation activity.…”

Section: Antifungal Activity Of Pharmaceutical Textilesmentioning

confidence: 99%

“…Patient compliance would be greatly improved if a regular piece of textile (such as bandage or socks) could be used instead of applying a cream daily. Antifungal textiles have been prepared by soaking the fabric into a solution of antifungals [12,13], and promising clinical results have been obtained from a sock prototype to treat tinea pedis [14]. However, fabrication technology and controlled release of antifungal agents still need to be improved.…”

Section: Introductionmentioning

confidence: 99%

Econazole imprinted textiles with antifungal activity

Hossain

Lalloz

Benhaddou

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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In this work, we propose pharmaceutical textiles imprinted with lipid microparticles of Econazole nitrate (ECN) as a mean to improve patient compliance while maintaining drug activity. Lipid microparticles were prepared and characterized by laser diffraction (3.5±0.1 μm). Using an optimized screen-printing method, microparticles were deposited on textiles, as observed by scanning electron microscopy. The drug content of textiles (97±3 μg/cm(2)) was reproducible and stable up to 4 months storage at 25 °C/65% Relative Humidity. Imprinted textiles exhibited a thermosensitive behavior, as witnessed by a fusion temperature of 34.8 °C, which enabled a larger drug release at 32 °C (temperature of the skin) than at room temperature. In vitro antifungal activity of ECN textiles was compared to commercial 1% (wt/wt) ECN cream Pevaryl®. ECN textiles maintained their antifungal activity against a broad range of Candida species as well as major dermatophyte species. In vivo, ECN textiles also preserved the antifungal efficacy of ECN on cutaneous candidiasis infection in mice. Ex vivo percutaneous absorption studies demonstrated that ECN released from pharmaceutical textiles concentrated more in the upper skin layers, where the fungal infections develop, as compared to dermal absorption of Pevaryl®. Overall, these results showed that this technology is promising to develop pharmaceutical garments textiles for the treatment of superficial fungal infections.

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“…According to some previous reports, foodborne pathogens can be divided into gram-negative bacteria ( Escherichia coli, Salmonella typhimurium, Vibrio parahaemoliticus, Clostridium perfringens, Klebsiella pneumoniae ), gram-positive bacteria ( Staphylococcus aureus, Listeria monocytogenes, Clostridium botulinum, Bacillus cereus, Bacillus anthracis ), and fungi ( Candida albicans, Candida parapsilosis, Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum) (1, 8, 15, 16). Therefore, E. coli, S. aureus, and C. albicans were selected as model microorganisms representing gram-negative and gram-positive bacteria, as well as fungi to complete this research.…”

Section: Introductionmentioning

confidence: 99%

The identification of critical lethal action in antimicrobial mechanism of glycerol monomyristate against foodborne pathogens

Xiong

et al. 2018

Preprint

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22Glycerol monomyristate (GMM) is a promising antimicrobial substance due to its broad 23 antibacterial spectrum: however, the critical lethal action in its antimicrobial mechanism 24 for foodborne pathogens remains unclear. In the present study, the inhibitory activities of 25 GMM on Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Candida 26 albicans (C. albicans) were compared, and its membrane and intracellular action 27 mechanism was investigated. The results showed that the susceptibility of E. coli to 28 GMM was the highest, followed by S. aureus, and C. albicans being the poorest. Using 29 flow cytometry, the GMM dose causing above 50% permeability ratio on E. coli was 30 lower than that on S. aureus. The images from scanning electron microscope revealed no 31 doses difference existed between the two strains when the obvious cell damage occurred. 32Furthermore, cell cycle and multiple fluorescent staining assays showed only the cell 33 division of E. coli and S. aureus, excluding that of C. albicans, was obviously affected at Importance 38 Foodborne pathogens, as a common source of biological pollution in the food industry, 39 can cause millions of food poisoning incidents each year, which poses great risks to 40 consumers' health and safety. The use of monoglyceride as an edible surfactant to inhibit 41 the growth of food-borne microorganisms has been a long time, but the relevant 42 3 antibacterial mechanism is too broad to accurately grasp its key lethal effect and its 43 action doses, which not only affects the antibacterial efficiency, but also may result in the 44 abnormalities of food flavor when adding at overdoses. The significance of the study is 45 to identify the key lethal effect and its action doses, which will greatly enhance the 46 understanding of the response mechanism of different types of foodborne pathogens to 47 monoglycerides, and provide a more reasonable reference for differential control and 48 treatment of different gastrointestinal infections when combined with antibiotics in 49 clinical. 50 51 52 53 54 55 56 57 58 59 60 61 62 63 4 Introduction 64Food safety is very important to global public health. The control of foodborne 65 pathogens has always been the major task in the food industry. There are millions of 66 gastrointestinal infection cases every year due to consuming foods contaminated with 67 harmful microbes (1). Owing to the concern of the potential toxicity of chemical 68 preservatives (2), researchers have been striving to find effective and safe substances to 69 replace traditional chemical preservatives such as benzoate, sorbate, and propionate (3). 70Monoglycerides are important non-ionic surfactants with broad antibacterial spectrum, 71 strong antibacterial activity, and high stability (4). Among them, glycerol monomyristate 72 (GMM) show both excellent bacterial and fungal inhibitory ability (5, 6). For example, 73 myristic acid and its monoglyceride showed a moderate inhibition effect on the growth of 74 Aspergillus, Penicillium, and Fus...

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Antifungal and antibacterial effects of 1‐monocaprylin on textile materials

Cited by 13 publications

References 20 publications

The key lethal effect existed in the antibacterial behavior of short, medium, and long chain fatty acid monoglycerides onEscherichia coli

The key lethal effect existed in the antibacterial behavior of short, medium, and long chain fatty acid monoglycerides onEscherichia coli

Econazole imprinted textiles with antifungal activity

The identification of critical lethal action in antimicrobial mechanism of glycerol monomyristate against foodborne pathogens

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