Antifungal and Insecticidal Properties of <i>Juniperus thurifera</i> Leaves

Jemli, Meryem El; Khattabi, Naima; Lachqer, Khadija; Touati, Driss; Jemli, Yousra El; Marmouzi, Ilias; Wakrim, El Mahdi; Cherrah, Yahia; Alaoui, Katim

doi:10.1177/1934578x1801300831

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Many strategies had been devoted to the control of A. flavus, F. oxysporum, A. niger, and C. albicans using different types of substances, either natural or chemically synthesized. Our results are in agreement with previous reports e.g., the study of Jemli et al [51], which showed a substantial antifungal activity against A. alternata, F. solani, F. oxysporum, V. dahlia, and R. solani with a percentage of inhibition ranging from 24% to 92.1%.…”

Section: Negative Control Foxysporum Calbicanssupporting

confidence: 94%

GC-MS Profiling, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Essential Oil of Juniperus thurifera Bark

Lafraxo

Moussaoui

Jardan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Juniperus thurifera is a native species to the mountains of the western Mediterranean region. It is used in traditional medicine as a natural treatment against infections. The present study aimed to carry out the chemical analysis and evaluate the antioxidant, antimicrobial, as well as in silico inhibition studies of the essential oils from Juniperus thurifera bark (EOEJT). Chemical characterization of EOEJT was done by gas chromatography (GC-MS). We have performed three antioxidant assays (Reducing power (FRAP), 2, 2-diphenylpicrylhydrazyl (DPPH), and total antioxidant capacity (TAC)) of the EOEJT. We next evaluated the antimicrobial activity against in silico study, which was carried out to help evaluate the inhibitory effect of EOEJT against NADPH oxidase. Results of the GC/MS analysis revealed seven major compounds in EOEJT wherein muurolol (36%) and elemol (26%) were the major components. Moreover, EOEJT possessed interesting antioxidant potential with an IC50 respectively of 21.25 ± 1.02 μg/mL, 481.02 ± 5.25 μg/mL, and 271 μg EAA/mg in DPPH, FRAP, and total antioxidant capacity systems. Molecular docking of EOEJT in NADPH oxidase active site showed inhibitory activity of α-cadinol and muurolol with a glide score of −6.041 and −5.956 Kcal/mol, respectively. As regards the antibacterial and antifungal capacities, EOEJT was active against all tested bacteria and all fungi, notably, against Escherichia coli K12 with an inhibition diameter of 21 mm and a MIC value of 0.67 mg/mL, as well as against Proteus mirabilis ATCC 29906 with an inhibition diameter of 18.33 ± 1.15 mm and a MIC value of 1.34 mg/mL. A more pronounced effect was recorded for the fungal pathogens Fusarium oxysporum MTCC 9913 with inhibition of 37.44 ± 0.28% and MIC value of 6.45 mg/mL, as well as against Candida albicans ATCC 10231 with an inhibition diameter of 20.33 ± 1.15 mm and a MIC value of 0.67 ± 0.00 mg/mL. Altogether, these results highlight the importance of EOEJT as a source of natural antibacterial and antioxidant drugs to fight clinically important pathogenic strains.

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Section: Negative Control Foxysporum Calbicanssupporting

confidence: 94%

GC-MS Profiling, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Essential Oil of Juniperus thurifera Bark

Lafraxo

Moussaoui

Jardan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…However, regarding the control of Verticillium wilts in general and VWO in particular, only a few studies are available. For instance, the hydro-distilled essential oil from the leaves of Juniperus thurifera L. was able to inhibit the mycelial growth of different phytopathogenic fungi, including V. dahliae [192]. Similarly, the variable in vitro mycelial growth inhibition of S. sclerotiorum, F. oxysporum, and V. dahliae was observed with essential oils extracted from Vaccinium myrtillus L., Laurus nobilis L., and Eucalyptus camaldulensis Dehnh [193,194].…”

Section: Plant Extracts Essential Oils and Seaweedsmentioning

confidence: 99%

Verticillium Wilt of Olive and Its Control: What Did We Learn during the Last Decade?

Montes-Osuna

Mercado‐Blanco

2020

Plants

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Verticillium (Verticillium dahliae Kleb.) wilt is one of the most devastating diseases affecting olive (Olea europaea L. subsp. europaea var. europaea) cultivation. Its effective control strongly relies on integrated management strategies. Olive cultivation systems are experiencing important changes (e.g., high-density orchards, etc.) aiming at improving productivity. The impact of these changes on soil biology and the incidence/severity of olive pests and diseases has not yet been sufficiently evaluated. A comprehensive understanding of the biology of the pathogen and its populations, the epidemiological factors contributing to exacerbating the disease, the underlying mechanisms of tolerance/resistance, and the involvement of the olive-associated microbiota in the tree’s health is needed. This knowledge will be instrumental to developing more effective control measures to confront the disease in regions where the pathogen is present, or to exclude it from V. dahliae-free areas. This review compiles the most recent advances achieved to understand the olive–V. dahliae interaction as well as measures to control the disease. Aspects such as the molecular basis of the host–pathogen interaction, the identification of new biocontrol agents, the implementation of “-omics” approaches to unravel the basis of disease tolerance, and the utilization of remote sensing technology for the early detection of pathogen attacks are highlighted.

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“…The ferric reducing antioxidant power assay was performed according to a previously established protocol [9]. Various concentrations of MEMC (0.25-1 mg/mL) were adjusted to a 2.5 mL volume and combined with 2.5 mL 0.2 M phosphate buffer (pH 6.6), and 2.5 mL 1% aqueous potassium hexacyanoferrate [K 3 Fe(CN) 6 ] solution.…”

Section: In Vitro Antioxidant Effectmentioning

confidence: 99%

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

Shovo

Tona

Mouah

et al. 2021

CIMB

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Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.

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Antifungal and Insecticidal Properties of Juniperus thurifera Leaves

Cited by 8 publications

References 15 publications

GC-MS Profiling, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Essential Oil of Juniperus thurifera Bark

GC-MS Profiling, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Essential Oil of Juniperus thurifera Bark

Verticillium Wilt of Olive and Its Control: What Did We Learn during the Last Decade?

Computational and Pharmacological Studies on the Antioxidant, Thrombolytic, Anti-Inflammatory, and Analgesic Activity of Molineria capitulata

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