Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds

Yessoufou, Kowiyou; Elansary, Hosam O.; Mahmoud, Eman A.; Skalicka-Woźniak, Krystyna

doi:10.1016/j.indcrop.2015.06.011

Cited by 45 publications

(47 citation statements)

References 48 publications

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“…The seed of açaí also demonstrated benefits for the cardiovascular, renal and neurological systems. Studies claim that natural products with polyphenols in their chemical composition show antioxidant and antiproliferative activity in neoplastic cells in vitro …”

Section: Discussionmentioning

confidence: 99%

Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF-7 cell line

Freitas

Morgado‐Díaz

Gehren

et al. 2017

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF-7 cell line

Freitas

Morgado‐Díaz

Gehren

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Antiproliferative and cytotoxic effects of stem extracts were tested on MCF-7, HeLa, Jurkat, and HT-29, as well as HEK-293 (human normal cells) [1, 2,16]. Extracts were solubilized in DMSO (1%).…”

Section: Anti-cancer Activitiesmentioning

confidence: 99%

“…Furthermore, IC 50 values were obtained by plotting the percentage of cell viability against extract concentration and expressed in µg/mL. The IC 30 and IC 50 were determined in the apoptotic cell population (flow cytometry, FAC Scan, Becton Dickinson, Iowa, USA) following [1, 15,16]. Control cells were untreated with extracts or methanol standards.…”

Section: Anti-cancer Activitiesmentioning

confidence: 99%

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

et al. 2019

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Discovering new natural resources of polyphenols is the aim of many recent studies in the field of natural product research. This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The dominant compounds were: gentisic acid in M. rhodantha and M. spinosissima; chlorogenic acid in M. muehlenpfordtii, M. crucigera, and M. rhodantha; and caffeic acid in M. rhodantha, M. crucigera, and M. spinosissima. Stems of Mammillaria sp. showed antiproliferative effects against HeLa, MCF-7, and Jurkat cells. In HeLa and MCF-7 cells, the best antiproliferative activities were found in the treatments with M. rhodantha, M. spinosissima, and M. muehlenpfordtii. The apoptotic assay of M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed accumulation of necrotic cells in the early and late apoptotic phase. M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed the highest anti-oxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric reducing anti-oxidant power (FRAP) assays. M. rhodantha was the best source of antioxidants. Mammillaria sp. showed moderate anti-bacterial effects against bacteria and the highest effects were found using the extracts of M. rhodantha, M. spinosissima, M. crucigera and M. muehlenpfordtii against most bacteria. The anti-bacterial activities were attributed to other phenolic compounds (e.g., chlorogenic acid) than gentisic acid, which was not active against most bacteria. Mammillaria sp. could be considered to be an important natural source of phenolic acids with anti-cancer, anti-bacterial, and anti-oxidant activities.

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“…Tree bark, for example, provides not only a physical protective barrier for plants, but also an important chemical defense mediated through the secondary compounds they produce (Horsfall 1980;Merrill 1992;Alfredsen et al 2008). Numerous studies recently conducted on bark extracts focus on tropical tree species (da Silva et al 2013;Kusumoto et al 2014;Salem et al 2015a;Yessoufou et al 2015). In the present study, we shift the focus onto Central European softwood species in the Pinaceae family (Salem et al 2015b).…”

Section: Introductionmentioning

confidence: 99%

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

Salem

Elansary

Elkelish

et al. 2016

BioRes

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Picea abies and Larix decidua were subjected to GC/MS analyses, and antimicrobial (fungi and bacteria) assays of their stem wood and bark extracts were investigated. L. decidua bark extract exhibited the highest antifungal and antibacterial activities against the microorganisms that were screened. The microbes Penecillium ochrochloron and Aspergillus ochraceus were the most sensitive to the extracts, whereas Candida albicans was the most resistant fungus. L. decidua wood and bark did not exhibit much variation in their antibacterial activities, except against Micrococcus flavus and Pseudomonas aeruginosa. The bacterium most sensitive to the extracts was Escherichia coli, whereas the most resistant was M. flavus. 13-epimanool and α-cedrol were the main components of P. abies wood extract. The main components in its bark were abietic acid, astringin, dehydroabietic acid, and α-terpineol. The main chemical compounds in L. decidua wood extract were abietic acid, oleanolic acid, duvatrienediol, and larixol. The main chemical compounds in its bark were (-)-2,9-dihydroxyverrucosane and larixol. The study revealed that P. abies and L. decidua stem wood and bark extracts contain several compounds that have antimicrobial activities towards diverse human pathogenic, food, and agricultural microbes. These results might guide in future searches for novel natural products with chemotherapeutic uses. (El-Shatby), Alexandria University, Alexandria, Egypt; b: Molecular Biology Laboratory, Floriculture, Ornamental Horticulture and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt; c: Department of Botany, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt; d: Department of Wood Processing, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic; e: Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; f: Department of Timber Trees Research, Sabahia Horticulture Research Station, Horticulture Research Institute, Agriculture Research Center, Alexandria, Egypt; g: Department of Environmental Sciences, University of South Africa, Florida campus, Florida 1710, South Africa; * Corresponding author: zidan_forest@yahoo.com; mohamed-salim@alexu.edu.eg Keywords: Picea abies; Larix decidua; Antifungal activity; Antibacterial activity; GC/MS Contact information: a: Department of Forestry and Wood Technology, Faculty of Agriculture INTRODUCTIONForestry residues such as tree barks and branches are important but underexplored supplies of biologically or pharmaceutically active compounds (Liimatainen et al. 2012;Si et al. 2012;Patinha et al. 2013). Tree bark, for example, provides not only a physical protective barrier for plants, but also an important chemical defense mediated through the secondary compounds they produce (Horsfall 1980;Merrill 1992;Alfredsen et al. 2008). Numerous studies recently conducted on bark extracts focus on tropical tree spec...

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Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds

Cited by 45 publications

References 48 publications

Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF-7 cell line

Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF-7 cell line

Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

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