Antifungal Characteristics of Spherical Carbon Materials with Zinc Oxide

Yamamoto, Osamu; Iida, Yasuhiro

doi:10.2109/jcersj.111.614

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…Previous studies have shown that cumulative masses of Candida are strongly resistant to drugs; therefore, to prevent the accumulation, growth and proliferation of these fungi at tissue surface or inorganic levels, it is necessary to identify and introduce antifungal agents that control or inhibit the growth of fungal elements (12). ZnO NPs are highly active against bacteria and can be used as antifungal agent (13,14).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and antifungal studies of biosynthesized zinc oxide nanoparticles using extract of Prosopis farcta fruit

Miri

Khatami

Ebrahimy

et al. 2020

Green Chemistry Letters and Reviews

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Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used mineral particles. These nanoparticles are biocompatible and safe which can be used in medical-related industries. In this study, ZnO NPs were synthesized through an aqueous extract of Prosopis farcta fruit. Biosynthesized nanoparticles were identified through Ultraviolet-visible (UV-Vis), Powder X-Ray Diffraction (PXRD), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray analysis (EDX), and Transmission Electron Microscopy (TEM) methods. The results of electron imaging showed that biosynthesized nanoparticles are hexagonal in shape with range size between 40 and 50 nm. Electron spectroscopy results showed that the bandgap of biosynthesized nanoparticles is 3.9 eV. The results of antifungal assay against Candida albicans showed 32-64 and 128-512 µg/ml values for minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), respectively. Cytotoxicity of nanoparticles against breast cancer cells (MCF7) was performed using WST-1 assay and its IC 50 was obtained 500 μg/ml.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic and antifungal studies of biosynthesized zinc oxide nanoparticles using extract of Prosopis farcta fruit

Miri

Khatami

Ebrahimy

et al. 2020

Green Chemistry Letters and Reviews

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“…Tam et al 33 reported that ZnO is more effective for gram-positive than gram-negative bacteria because the formers have simpler cell membrane structure. The antifungal activity was evident in the carbon samples containing ZnO 32 . The ZnO-eugenol cement was more effective in reducing Candida spp.…”

Section: Resultsmentioning

confidence: 98%

“…ZnO inhibited about 90% of S. aureus growth and about 50% of C. albicans growth at concentration of 5 mg/10 ml, whereas ZnO inhibited E. coli in a dose dependent fashion from 0-100 mg/10 ml ZnO and the highest inhibition was 50% of E. coli growth. Many reports showed that ZnO could be used as antimicrobial agent [29][30][31][32] , as it exhibited antimicrobial activity against S. aureus 29 and E. coli 7,30 . The antibacterial activity of ZnO increased with the concentration 29 in agreement with the present investigation of anti-E. coli.…”

Section: Resultsmentioning

confidence: 99%

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Phaechamud¹,

Mahadlek²,

Aroonrerk³

et al. 2012

ScienceAsia

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Zinc oxide (ZnO) is a prototype of micro-and nanomaterials widely studied in different fields due to many promising new applications. Various zinc oxides (typical, micronized, powder, tetrapod I, and tetrapod II ZnO) have been characterized using SEM. The particle size of zinc oxides was analysed using laser light diffraction spectroscopy. Effects of types and amounts of ZnO on the antimicrobial activity were evaluated using Staphylococcus aureus, Escherichia coli, and Candida albicans as standard microbes. Lutrol F127 systems comprising ZnO and doxycycline hyclate were developed. Cytotoxicity of test samples and gel was investigated on human gingival fibroblast and macrophage cell line U937. Particle size analysis revealed that micronized ZnO was smaller than ZnO powder, ZnO BP, tetrapod I, or II zinc oxides. The particle size of tetrapod zinc oxides was larger than the others since they exhibited an arm structure configuration. The antibacterial activity depended on the particle size of ZnO, whereas the antifungal activity was less affected by the particle size. Increasing ZnO in the doxycycline hyclate-Lutrol F127 systems decreased the inhibition zone diameters against all test microbes investigated with agar diffusion method because it retarded drug diffusion. This effect could prolong the doxycycline hyclate release. N-methyl-2-pyrrolidone could enhance the antifungal activity of doxycycline hyclate thermosensitive gel. The developed system could inhibit bacteria in the oral cavity. All 10 mg/ml test samples were not toxic to human gingival fibroblast or macrophage cell line, however Lutrol F127 and doxycycline hyclate showed a slight effect but no significant difference from that of the control group. Therefore, ZnO combined with doxycycline hyclate could prolong the inhibition of microbes in the form of thermosensitive gel to use in localized periodontitis therapy.

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“…This led us to investigate what factors delimit antifungal activity of ZnO hierarchical particles. Some authors report the higher resistance of fungi to ZnO that may come from their less sensitivity to ROS [40,41]. However, the presence of Zn +2 cations can alter the respiratory chain of cells, causing their death [42].…”

Section: Looking For the Main Factors Of Antifungal Activitymentioning

confidence: 99%

One more step against nanotoxicity: Hierarchical particles designed to antifungal properties

2017

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The interest that awakens the ZnO as material is greatly extended both by its unique properties as by its wide variety of applications. Within these applications, antimicrobial activity is gaining relevance. Especially, the bactericidal activity of ZnO nanoparticles is outstanding but little is known about antifungal activity. In addition, the recent discussion about the potential toxicity of nanoparticles and their massive use places them in the spotlight. In response to this emerging problem, a simple and general approach to synthesize hierarchical structure of ZnO is reported. A formation mechanism of these surprising structures is proposed. Moreover, the obtained zinc oxide hierarchical particles improves the antifungal activity towards Aspergillus niger in contrast to ZnO micro or nanoparticles. Due to surprising results, the different action mechanisms of ZnO hierarchical particles against fungi are studied. Thus, we pose a novel physical mechanism by which ZnO hierarchical particles achieve excellent fungicidal results.

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Antifungal Characteristics of Spherical Carbon Materials with Zinc Oxide

Cited by 11 publications

References 12 publications

Cytotoxic and antifungal studies of biosynthesized zinc oxide nanoparticles using extract of Prosopis farcta fruit

Cytotoxic and antifungal studies of biosynthesized zinc oxide nanoparticles using extract of Prosopis farcta fruit

Untitled

One more step against nanotoxicity: Hierarchical particles designed to antifungal properties

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