Antifungal constituents of Melicope borbonica

Abstract

Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.

The Bisabolane Sesquiterpenoid Endoperoxide, 3,6-Epidioxy-1,10-bisaboladiene, Isolated fromCacalia delphiniifoliaInhibits the Growth of Human Cancer Cells and Induces Apoptosis

“…7,12,13) Our result is the first case showing the presence of EDBD in C. delphoniifolia and its anti-tumor activity in vitro.…”

“…1A) in the reference, except some NMR assignments. 7) EDBD has previously been isolated from Melicope borbonica, 7) Senecio paludaffinis, 8) Ligularia speciosa, 9) Chamaemelum fuscatum, 10) Artemisia xanthochroa, 11) and Santolina rosmarinifolia subsp. Canescens.…”

Antimicrobial evaluation of Huilliche plant medicine used to treat wounds

“…A thin-layer chromatographic agar overlay technique (Simonsen et al, 2004) ), 1205-05 (serotype 14) and 1322-05 (serotype 6B)). The extracts were dissolved in an appropriate solvent.…”

Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities

“…The known compounds (2R,4R)-1,2,4-trihydroxynonadecane (6) (Oberlies et al, 1998), (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) (Oberlies et al, 1998), (2R,4R)-1,2,4-trihydroxyheptadec-16-yne (8) (Oberlies et al, 1998), (2R,4R,6E)-1,2, 4-trihydroxynonadec-6-ene (9) (Abe et al, 2005), (2R,4R)-1-acetoxy-2,4-dihydroxyheptadec-16-ene (10) (Domergue et al, 2000), (2R,4R)-1-acetoxy-2,4-dihydroxyheptadec-16-yne (11) (Domergue et al, 2000), 1,4-diacetoxy-2-hydroxyheptadec-16-ene (12) (Huang, 2004), oleic acid (13) (Pouchert & Behnke, 1993), scopoletin (14) (Chen, Chen, Chang, Teng, & Lin, 1999), cedrelopsin (15) (Simonsen et al, 2004), and a mixture of b-sitosterol (16) and stigmasterol (17) (De-Eknamkul & Potduang, 2003) were identified by comparison of their physical and spectroscopic data ([a] D , IR, 1 H, 13 C NMR, and MS) with values reported in the literature.…”