Antifungal derivatives from Piper mollicomum and P. lhotzkyanum (Piperaceae)

Lago, João Henrique G.; Young, Maria Cláudia M.; Reigada, Juliana B.; Soares, Marisi G.; Roesler, Bianca P.; Kato, Massuo Jorge

doi:10.1590/s0100-40422007000500032

Cited by 28 publications

(22 citation statements)

References 15 publications

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“…Compound 29 gave an MAR of 1.0 μg against both C. sphaerospermum and C. cladosporioides , the same MAR generated by the positive control nystantin, while Compound 30 afforded MAR of 1.0 and 5.0 μg, respectively [9]. Compound 29 was also isolated as an antifungal constituent from P. lhotzkyanum [10] and P. marginatum [11]. The analog 5,7-dihydroxy-4′-methoxyflavanone ( 31 ) isolated from P. marginatum [11] also demonstrated the same antifungal activity as sakuranetin against the aforementioned two fungal pathogens.…”

Section: Flavonoidsmentioning

confidence: 99%

Antifungal Compounds from Piper Species

Xu¹,

Li²

2011

CBC

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Section: Flavonoidsmentioning

confidence: 99%

Antifungal Compounds from Piper Species

Xu¹,

Li²

2011

CBC

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“…Studies of Piper species have revealed the presence of several classes of secondary metabolites, 1 including alkaloids, amides, 2-6 chromenes, 7,8 neolignans, 9 lignans, terpenes, 10,11 benzoic acid derivatives 12,13 and kavalactones.…”

Section: Introductionmentioning

confidence: 99%

Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)

Mazzeu¹,

Felippe²,

Cotinguiba³

et al. 2017

J. Braz. Chem. Soc.

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The known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methoxy-3-(3'-methyl-2'-butenyl)benzoate and methyl 2,2-dimethyl-4-oxochroman-6-carboxylate, and a new methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate were isolated from the ethanolic extract of Piper fuligineum. The structures of these compounds were determined by using a combination of spectroscopic methods, including 1D-and 2D-nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. This is the first report of the chemical study of P. fuligineum, and the methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate is described as a new natural product.

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“…A Piper mollicomum pertence à família Piperaceae e é conhecida como "jaborandi-manso" ou apenas "jaborandi" (Peckolt & Peckolt, 1888). Poucos estudos fitoquímicos foram realizados com a P. mollicomum, entre eles a análise da composição do óleo essencial, mostrando que é composto principalmente por sesquiterpenos (Santos et al, 2001), e o isolamento de dois cromenos e uma chalcona com atividade antifúngica (Lago et al, 2007).…”

Section: Introductionunclassified

Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

Potrich

Baggio

Freitas

et al. 2014

Rev. bras. plantas med.

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Palavras-chave: plantas medicinais, distúrbios gastrointestinais, esvaziamento gástrico, trânsito intestinalABSTRACT: Action of medicinal plant extracts on the gastrointestinal tract motility. Many plants are popularly used for the treatment and healing of diseases. The Persea major Kopp, Piper mollicomum Kunth. and Serjania erecta Radlk. are used in several illnesses, including the treatment of disorders of the gastrointestinal tract. The aim of this study was to evaluate the effects of the extracts of these plants on the gastrointestinal motility. Swiss mice were orally treated with extracts one hour before the administration of a semisolid solution of 1.5% carboxymethylcellulose and 0.05% phenol red. After 15 minutes, the gastric emptying and intestinal transit were determined. The hydroalcoholic extract of P. major (100 to 1000 mg Kg -1 , p.o.) and the hydroalcoholic extract of P. mollicomum (100 and 300 mg Kg -1 , p.o.) increased the intestinal transit. However, only the P. major extract (100 and 300 mg Kg -1 ) increased the gastric emptying. The ethanolic extract of S. erecta (100 to 1000 mg Kg -1 , p.o.) did not alter the gastrointestinal motility. These results suggest that Persea major and Piper mollicomum can be of interest for further studies in the search of active principles or effective plant material for the treatment of disorders of the gastrointestinal tract, such as constipation. INTRODUÇÃOA utilização de plantas no tratamento de enfermidades é relatada como sendo uma das práticas mais antigas da humanidade (Calixto, 2001). E por isso, acredita-se que as plantas medicinais foram testadas e homologadas através do seu uso prolongado, considerando-as eficazes e seguras, sem efeitos colaterais (Lapa et al., 2000). Neste contexto, são de extrema importância o estudo e a validação do uso de plantas medicinais que apresentem indicações populares.

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Antifungal derivatives from Piper mollicomum and P. lhotzkyanum (Piperaceae)

Cited by 28 publications

References 15 publications

Antifungal Compounds from Piper Species

Antifungal Compounds from Piper Species

Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)

Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

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