Antifungal effect of plant extracts on Candida albicans biofilm on acrylic resin

Oliveira, Jonatas Rafael de; Vilela, Polyana das Graças Figueiredo; Oliveira, Felipe Eduardo de; Belato, Kely Karina; Carvalho, Cláudio Antônio Talge; Jorge, Antônio Olavo Cardoso; Oliveira, Luciane Dias de

doi:10.14295/bds.2013.v16i3.909

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…37 The results of a study by de Oliveira et al about the effects of E. arvense and P. granatum peel extracts on C. albicans biofilm were also quite consistent with the results of the inoculation study. 38 In a study, Menezes et al evaluated the efficacy of hydroalcoholic Pomegranate extract on orthodontic dental plaques in 60 patients and compared to CHX as a standard. In their study, two-stage orthodontic plates were tested: once before mouthwash and once after.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial and Cytotoxicity Activities of Some Medicinal Plant Extracts against Oral Microbial Pathogens

Amirinia¹,

rad²,

Pourhajibagher³

2021

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Introduction: Medicinal plants have long been of great interest to scientists in the search for the best treatment of diseases, especially the infectious diseases. In recent years, the use of herbal medicines has become more well-known because of their antimicrobial, antifungal, anti-cancer and less side effects. Aim: The aim of this study was to investigate the antimicrobial and antifungal effects of Urtica dioica, Equisetum arvense, and Punica Granatum peel extracts on two common oral microorganisms, Streptococcus mutans and Candida albicans. Materials and methods: The study investigated the hydro-alcoholic extract of the plants. The antimicrobial activity of the extracts was evaluated using the method of measuring the inhibition of microorganisms, and the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined using different concentrations of the extracts and also biofilm assay and SEM were determined. Also cell viability was assessed by MTT assay on human gingival fibroblast cells. Results: The lowest MIC against S. mutants and C. albicans was related to the hydro-alcoholic extract of U. dioica. There was a significant reduction in the microbial biofilms by all three extracts. Among them, U. dioica could decrease the biofilms of S. mutans and C. albicans more than other extracts. In addition, the best results for growth inhibition zone were the hydro-alcoholic extracts of E. arvense and U. dioica with 35 and 30 mm growth zone, respectively. The results of SEM showed that P. granatum peel, U. dioica and E. arvense could destroy microbial biofilms without exerting any cytotoxic effects on HGF cell. Conclusions: The results of the study suggest that U. dioica, E. arvense, and P. Granatum peel extracts can be used as mouthwash with the least significant difference with routine mouthwashes. Also, the plant-based mouthwashes may be more suitable substitutes for chemical types in the future.

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Section: Discussionmentioning

confidence: 99%

In Vitro Antimicrobial and Cytotoxicity Activities of Some Medicinal Plant Extracts against Oral Microbial Pathogens

Amirinia¹,

rad²,

Pourhajibagher³

2021

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“…On the other hand, the antifungal activity of the “barbatimão” species is more significant and different studies have attempt to elucidate the mechanism involved in the Candida spp virulence, biofilm inhibition, as well as the main active compound [ 42 , 114 , 122 ]. The propylene glycol extract of S. adstringens inhibited the formation of C. albicans biofilm on acrylic resins [ 123 ]. To elucidate the main active compound, Ishida et al [ 42 ] performed bioguided extract fractionation according to the growth inhibition of C. albicans , which yielded a group of subfractions from the aqueous partition and the ethyl acetate fraction contained the polymer of 2114 Da with six units of flavan-3-ol and one galloyl group.…”

Section: Correlated Biological Activitiesmentioning

confidence: 99%

Stryphnodendron Species Known as “Barbatimão”: A Comprehensive Report

2018

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Stryphnodendron spp., popularly known as “barbatimão”, is the native Brazilian tree most often employed to treat wounds and infections. The aim of the present study was to highlight the importance of S. adstringens, as well as other Stryphnodendron species recognized as “barbatimão”, to human health, depicting the relevance of ethnopharmacological knowledge to scientific evidence for uses, related chemical compounds, development of pharmaceutical formulations, and the establishment of toxicity parameters. For this purpose, the literature databases PubMed, Scielo, Lilacs, CAPES Thesis and Google Scholar were searched until 2017. It was observed that stem bark was the primary part of the plant used, mainly as a decoction, for wound healing and treatment of infectious and inflammatory disorders. Confirmed biological activities, including wound healing, anti-inflammatory, antioxidant, and antimicrobial activities, were related to the presence of compounds from tannin class, mostly proanthocyanidins. Toxicity parameters for stem bark were inconclusive, but toxicity was observed to a significant extent when seeds were ingested by cattle or other animals. Due to these important and confirmed biological activities, government policy encourages the phytotherapic use of S. adstringens, and some formulations with stem bark extracts were developed and patented. Furthermore, antiprotozoal, hypoglycemic and antiviral activities were identified as promising.

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New Technological Approach for Glycyrrethic Acid Oral and Topical Administration

Pagano

Perioli

Calarco

et al. 2020

CPD

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Background: 18β- glycyrrhetinic acid (Gly) is the major bioactive component of licorice roots and rhizomes of the Glycyrrhiza glabra species. It shows many activities such as antiviral, anti-inflammatory, antioxidant, antimicrobial, and antifungal, however, its use in the health field is very limited due to the low water solubility. Methods: This paper deals with the development of a new technological approach for Gly dissolution rate enhancement. It consists of Gly intercalation (guest) in the interlamellar spaces between the inorganic spaces (host) of the anionic clays “hydrotalcites” (HTlc) to obtain hybrids MgAl-HTlc-Gly and ZnAl-HTlc-Gly. Gly can find applications in both systemic and local therapies, thus advantages of the use of the hybrids in these two fields were investigated. Results: Gly dissolution rate from hybrids in the intestinal environment, site in which it is preferentially absorbed, resulted enhanced (ZnAl-HTlc-Gly > MgAl-HTlc-Gly) compared to the crystalline form, thereby, making them suitable for oral administration as dry powder in hard capsules. : For a local therapy, bioadhesive, vaginal emulgels loaded with the hybrids were developed. These showed suitable mucoadhesive property to the vaginal mucosa, necessary to prolong the residence time in the application site. The emulgel containing ZnAl-HTlc-Gly showed a faster and higher release profile than that containing MgAl- HTlc-Gly. Conclusions: The obtained results suggest that Gly intercalation into HTlc, especially in ZnAl-HTlc, allows to enhance Gly dissolution when the hybrids are formulated both as oral or topical products.

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Antifungal effect of plant extracts on Candida albicans biofilm on acrylic resin

Cited by 4 publications

References 32 publications

In Vitro Antimicrobial and Cytotoxicity Activities of Some Medicinal Plant Extracts against Oral Microbial Pathogens

In Vitro Antimicrobial and Cytotoxicity Activities of Some Medicinal Plant Extracts against Oral Microbial Pathogens

Stryphnodendron Species Known as “Barbatimão”: A Comprehensive Report

New Technological Approach for Glycyrrethic Acid Oral and Topical Administration

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