Antifungal efficacy of herbs

Abstract

The aim of our study was to find the antifungal activities at MIC of selected fifteen plant leaves extracts prepared in three different solutions (methanol and ethanol) against the opportunistic pathogen Candida albicans isolated from oral cavity infections. It may also help the clinician to treat the patient not only for the particular lesion that is present, but also to treat the infection by Candida albicans so as to reduce its potential to malignant transformation. Material n methods: Leaves extract of selected plant prepared in methanolic and eethanolic solution have been chosen for the investigation of in vitro antifungal activity which acts as expectorant and not having toxic properties on humans while for comparison or control, antifungal drugs have been taken. Results showed that Candida albicans shows most sensitivity towards the standard antibiotic cotrimoazol but very less towards other drugs like Fluconazole, minocycline, erythromycin respectively which indicated Candida albicans shows some resistance character towards drugs while the herbal extracts of Lawsonia inermis, Withania somnifer, Curcuma longa, Cymbopogon citrates and Zingiber officinale gives the best inhibitory effect and they have the potential to control growth of Candida albicans.

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

“…The antifungal activity was evaluated using all 12 different fractions extracts of methanol and hexane and their mixtures using plant extract of W. coagulans against A. niger and C. albicans by the disc method [ 52 ]. The active biomolecules were resolved into simple W. coagulans plant molecules that exhibited antifungal activity.…”

“…The active principal molecules were measure and made visible by the zone of inhibition produced by the fraction molecules against the specific strains (Figure 9a-h). The antifungal activity was evaluated using all 12 different fractions extracts of methanol and hexane and their mixtures using plant extract of W. coagulans against A. niger and C. albicans by the disc method [52]. The active biomolecules were resolved into simple W. coagulans plant molecules that exhibited antifungal activity.…”

Innovations for prevention and care of oral candidiasis in HIV‐infected individuals: Are they available?—A workshop report

“…A recent study by Samadi et al. (2019) reported that of fifteen herbs randomly selected, extracts of Lawsoniainermis , Withaniasomnifer , Curcuma longa , Cymbopogon citrates, and Zingiberofficinale showed potent inhibitory effects and had potential to control growth of C. albicans .…”

“…FIC index is defined as the sum of the MIC of each drug in combination, divided by the MIC of the drug used alone. An FIC index 0.5 is considered synergism; FIC index 0.5–4 is indifferent; and FIC index > 4 is antagonism (Odds 2003) Several mechanisms of action can involve inhibition of (a) germination and biofilm formation, (b) cell metabolism, (c) cell wall integrity, and (d) cell membrane plasticity or induction of apoptosis (Samadi et al., 2019).…”

“…Present modern biotechnology techniques advance the commercial production of anti‐ Candida active plants and improve the activity of plant extracts, for example, the nanostructure lipid system can enhance the anti‐microbial activity of the extracts and reduce doses and side effects (Samadi et al., 2019). Bonifácio et al (2015)revealed that a nanostructure lipid system can reduce the MIC of a plant extract about nine times.…”