Antifungal mechanism of action of <i>Schinus lentiscifolius</i> Marchand essential oil and its synergistic effect <i>in vitro</i> with terbinafine and ciclopirox against dermatophytes

Danielli, Letícia Jacobi; Pippi, Bruna; Duarte, Jonathaline Apollo; Maciel, Ana Julia; Lopes, William; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de; Vainstein, Marilene Henning; Teixeira, Mário Lettieri; Bordignon, Sérgio A. L.; Apel, Miriam Anders

doi:10.1111/jphp.12949

Cited by 31 publications

(27 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, in this study, it was evidenced that (if compared with their uncombined effect) the associations of monoterpenes-terbinafine led to enhancements in inhibiting the growth of M. canis LM 216. Association of terbinafine and Schinus lentiscifolius essential oil was studied by Danielli et al (2020). The authors also confirmed that the natural drug can act on the fungal cell membrane as a chemosensitizer of the dermatophytes cells to the terbinafine, by a synergistic interaction (checkerboard).…”

Section: Resultsmentioning

confidence: 67%

Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Pinto

Oliveira

Medeiros

et al. 2020

Lett Appl Microbiol

View full text Add to dashboard Cite

Significance and Impact of the Study: This is the first study that describes the dihydrojasmone and terpinolene action enhancing the antifungal activity of terbinafine against dermatophytes. In vitro tests have demonstrated that the monoterpenes act on the plasma membrane, positively modulating the sensitivity of fungal strains to terbinafine by a synergism association. We suggest that monoterpenes can be an effective and sustainable alternative while contributing to the reduction of the dermatophytes resistance to conventional drugs.

show abstract

Section: Resultsmentioning

confidence: 67%

Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Pinto

Oliveira

Medeiros

et al. 2020

Lett Appl Microbiol

View full text Add to dashboard Cite

show abstract

“…Essential oils are an important group of secondary plant metabolites used in large scale in cosmetics, food, and pharmaceutical industries owing to their correlated biological effects [1,2,3]. Due to their repellent or attractive properties, these metabolites have been implicated in several ecological and biological functions, and different chemical profiles have been observed throughout plant development in response to biotic or abiotic environmental factors [4].…”

Section: Introductionmentioning

confidence: 99%

Influence of Monoterpenes in Biological Activities of Nectandra megapotamica (Spreng.) Mez Essential Oils

et al. 2019

View full text Add to dashboard Cite

Investigating the influence of seasonal variations on biological activities is important for pharmacological studies and metabolic engineering. Therefore, this study was conducted to determine the variation of the chemical composition of essential oils obtained from Nectandra megapotamica leaves, collected at different stages of plant development, as well as its influence on the biological activities. A total of 38 compounds were identified that accounted for 97–99.2% of the chemical composition of the oils. Major differences were observed in the monoterpenic fraction, representing 5.1% of the compounds identified in the productive rest phase to 37.1% in the blooming phase. Bicyclogermacrene and germacrene D were the predominant compounds identified in the oil of all collections. Furthermore, limonene, β-pinene, and spathulenol were identified predominantly in the samples of blooming and fruiting phases. The oils exhibited significant antichemotactic activity and different effects in scavenging the radical 2,2-diphenyl-1-picrylhydrazyl. Variations were also observed in the antifungal activity, with the minimum inhibitory concentrations ranging from 125 to 500 μg/mL. These results demonstrate the influence of monoterpenes, primarily limonene, α-pinene, and β-pinene, on the bioactivities of the oil. Studies investigating the variations in the chemical composition of essential oil may offer a strategy to produce a compound or a group of compounds of interest to industries with a specific pharmacological focus.

show abstract

“…They reported increases in the geraniol MIC by 64-fold, citronellol MIC by 32-fold, and the eugenol MIC by 4-fold when adding sorbitol; these findings suggested that compounds can interfere with the cell wall. Danielli et al [15] the MIC by 2 to 8 times in six of the strains [15]. These results also suggested that this EO acted on the fungal cell wall.…”

Section: Sorbitol Protection Assaymentioning

confidence: 87%

A review of the methods used to determine the target site or the mechanism of action of essential oils and their components against fungi

2021

View full text Add to dashboard Cite

Essential oils (EOs) are complex mixtures of compounds derived from plants that exhibit antimicrobial activity. Several studies have demonstrated their antifungal activity in food matrices or in vitro via vapor phase or direct addition. Recently, researchers are focusing on elucidating the target site or the mechanism of action of various EOs. Past research has suggested evidence of how EOs act in the fungal cells via assays assessed from cell wall alterations or gene expression modifications. However, no previous reports have summarized most methods for finding the target site of the mechanism of action for EOs. Therefore, this review presents the methods and assays used to discover the target site or the mechanism of action of EOs against fungal cells. Researchers commonly analyze the plasma membrane integrity using various techniques as well as the changes in cell morphology. Meanwhile, the quantification of the activity of the mitochondrial enzymes, ROS species, and gene expression are less assayed.

show abstract

Antifungal mechanism of action of Schinus lentiscifolius Marchand essential oil and its synergistic effect in vitro with terbinafine and ciclopirox against dermatophytes

Abstract: Schinus lentiscifolius essential oil acted as a chemosensitizer of the fungal cell to the drug, resulting in an improvement in the antifungal effect. Therefore, this combination can be considered as an alternative for the topical treatment of dermatophytosis.

Cited by 31 publications

References 36 publications

Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Influence of Monoterpenes in Biological Activities of Nectandra megapotamica (Spreng.) Mez Essential Oils

A review of the methods used to determine the target site or the mechanism of action of essential oils and their components against fungi

Contact Info

Product

Resources

About