Significance and Impact of the Study: This is the first study that describes the dihydrojasmone and terpinolene action enhancing the antifungal activity of terbinafine against dermatophytes. In vitro tests have demonstrated that the monoterpenes act on the plasma membrane, positively modulating the sensitivity of fungal strains to terbinafine by a synergism association. We suggest that monoterpenes can be an effective and sustainable alternative while contributing to the reduction of the dermatophytes resistance to conventional drugs.

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