Evaluating the Antifungal Activity of α-Bisabolol in Association with NaCl on Fusarium oxysporum in Maize Grains

Medeiros, César Augusto Costa de; Pinto, Ânderson de Vasconcelos; Oliveira, Josenildo Cândido de; Silva, Gezaíldo S.; Mendes, Juliana Moura; Lima, Igara Oliveira; Pereira, Fillipe de Oliveira

doi:10.1007/s00284-020-02313-8

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Additionally, α-Bisabolol exhibited a more potent growth inhibition for Fusarium oxysporum with low minimum inhibitory concentration (MIC) when compared with NaCl. The combination of both α-Bisabolol and NaCl resulted in an eightfold reduction in NaCl MIC, indicating a favorable synergism aimed to decrease administered antifungal agent [ 104 ]. On the other hand, α-Bisabolol was evaluated for an antiparasitic activity on Trypanosoma cruzi , where it was indicated that, α-Bisabolol induces cell death in Trypanosoma cruzi by triggering apoptosis, increasing ROS production, causing mitochondrial transmembrane potential dysfunction, and inhibiting tcGAPDH enzyme; detected by docking study which revealed that α-Bisabolol occupies the same site as chalepin (known inhibitor of tcGAPDH) does [ 105 ].…”

Section: α-Bisabolol and Antimicrobial Effectsmentioning

confidence: 99%

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

et al. 2022

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α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from essential oils of many edible and ornamental plants. It was first obtained from Matricaria chamomilla, commonly known as chamomile or German chamomile. The available literature indicates that this plant along with other α-Bisabolol containing plants is popularly used in traditional medicine for potential health benefits and general wellbeing. Nutritional studies are indicative of the health benefits of α-Bisabolol. Numerous experimental studies demonstrated pharmacological properties of α-Bisabolol including anticancer, antinociceptive, neuroprotective, cardioprotective, and antimicrobial. This review aims to collectively present different pharmacological activities based on both in vitro and in vivo studies. In the present review using synoptic tables and figures, we comprehensively present that α-Bisabolol possesses therapeutic and protective activities, therefore, it can be used for potential health benefits based on pharmacological effects, underlying molecular mechanism, and favorable pharmaceutical properties. Based on the studies mostly performed in cell lines or animal models, it is evident that α-Bisabolol may be a promising nutraceutical and phytomedicine to target aberrant biological mechanisms which result in altered physiological processes and various ailments. Given the polypharmacological effects and pleiotropic properties, along with favorable pharmacokinetics, and dietary availability and safety, α-Bisabolol can be used as a dietary agent, nutraceutical or phytopharmaceutical agent or as an adjuvant with currently available modern medicines. The regulatory approval of this molecule for use as food additives, and in cosmetics and fragrance industry is also supportive of its human usage. Moreover, further studies are necessary to address pharmaceutical, pharmacological, and toxicological aspects before clinical or nutritional usage in humans. The pharmacological effects and biological actions opens up opportunities on the pharmacological basis of its use in future therapeutics.

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Section: α-Bisabolol and Antimicrobial Effectsmentioning

confidence: 99%

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

et al. 2022

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“…Α-Bisabolol is an essential oil containing monocyclic sesquiterpene alcohol that was first identified and extracted from Matricaria chamomilla [7]. It has been used commonly as a fragrance ingredient in cosmetics and personal care product formulations due to its significant biological properties such as anti-inflammatory, anti-irritant, anti-inflammatory, anti-microbial, and anti-fungal activities [8]. In addition, α-bisabolol is used in the formulation of a wide variety of products, including facial makeup, skincare, and hair care products.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Detergency Properties and Anti-Microbial Action of Biosoaps Using Saponin-Rich Extract and Α-Bisabolol Essential Oil

2023

JST: ETSD

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In this study, natural ingredients were added to bio-soaps, synthesized from castor oil, a plant-derived ingredient, to improve the detergency, anti-bacterial, and stability capabilities (saponin from Soapacean fruit and essential oil of chamomile) of such soap. The saponin from soapnut fruit was extracted by an extraction process based on ethanol extraction. The saponin concentration in the extract was determined by the UV-Vis spectroscopy method. By evaluating the height and stability of the foam column, the surface tension using the Du Noüy method, and critical micelle concentrations (CMC), we looked into the efficiency of saponin in enhancing soap properties. The results show that saponin will reduce the value of CMC and, at the same time, expand the working limit of soap in brackish water and hard water (containing Mg2+ and Ca2+ ions). In addition, the presence of saponins and α-Bisabolol essential oil enhanced the anti-bacterial properties of the soap. These results expand the possibility of using natural substances in making green products that are clean and safe for humans and the environment.

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“…En los últimos años se ha incrementado el interés por métodos alternativos para control de estos patógenos, principalmente en el periodo de almacenamiento y/o conservación, como el uso de antioxidantes y aceites esenciales, que han presentado prometedores resultados por la capacidad de reducción y/o inhibición del crecimiento fúngico y por consiguiente la producción de micotoxinas (2,13,14,15) .…”

Section: Introductionunclassified

Comparación de técnicas de tamizaje de actividad antifúngica de aceites esenciales de especias frente cepas de Aspergillus aisladas de maní (Arachis hypogaea)

Reyes-Caballero

Cabrera

Cazal

et al. 2022

Rev. Soc. cient. Parag.

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La contaminación de los alimentos con hongos del género Aspergillus, representa un problema y amenaza para la seguridad e inocuidad alimentaria, estos microorganismos producen micotoxinas, metabolitos secundarios termoestables que causan intoxicaciones agudas o crónicas, inclusive muertes, en humanos y animales. Puede afectar diversos cultivos en condiciones de campo y almacenamiento, como el maní, que es muy susceptible a la contaminación por Aspergillus. Ante la creciente necesidad de desarrollar alternativas de control de estos patógenos principalmente en el almacenamiento y/o conservación, las búsquedas se han centrado y direccionado al desarrollo de tecnologías efectivas que representen un recurso sustentable y sostenible para el área alimentaria. El uso de aceites esenciales ha presentado resultados alentadores, además de su potencial antifúngico, ya que es una alternativa natural y biodegradable. Se propuso como objetivo de este estudio comparar dos técnicas de inoculación: siembra directa y medio inoculado en el método de tamizaje de actividad antifúngica - difusión en agar - de aceites esenciales de especias y sus principales fitoconstituyentes contra cepas de Aspergillus aisladas de maní. Y a su vez, determinar el efecto antifúngico frente a las cepas de Aspergillus estudiadas. Los aceites esenciales de Cinnamomum zeylanicum (canela), Eugenia caryophyllata (clavo de olor), Origanum vulgare (orégano), y los fitoconstituyentes: carvacrol y eugenol presentaron potencial efecto antifúngico sobre las cepas de Aspergillus flavus y Aspergillus Sección Nigri aislados de maní. Además, considerando que la reproducibilidad y estandarización de las técnicas de los ensayos antifúngicos con productos naturales son cruciales, en este estudio no se observaron diferencias significativas en las técnicas de inoculación ensayadas. Concluimos que los aceites esenciales ensayados son recursos naturales promisorios que requieren investigación adicional para ser aplicados como alternativas en la conservación de alimentos.

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Evaluating the Antifungal Activity of α-Bisabolol in Association with NaCl on Fusarium oxysporum in Maize Grains

Cited by 5 publications

References 32 publications

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

Improvement of Detergency Properties and Anti-Microbial Action of Biosoaps Using Saponin-Rich Extract and Α-Bisabolol Essential Oil

Comparación de técnicas de tamizaje de actividad antifúngica de aceites esenciales de especias frente cepas de Aspergillus aisladas de maní (Arachis hypogaea)

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