Antifungal meroterpenes and dioxolanone derivatives from plant-associated endophytic fungus Phyllosticta sp. WGHL2

Yan, Wei; Zhao, Shuangshuang; Gu, Chenguang; Tian, Kailin; Wang, Zhiyang; Liu, Fang; Ye, Yonghao

doi:10.1016/j.fitote.2020.104778

Cited by 9 publications

(2 citation statements)

References 22 publications

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“…The interaction from H-7b to the olefin H-10 indicated a δ-transoid conformation of the α, β-unsaturated ketone at C-8 with a cis -relationship of the methyl and hydroxymethylene groups as illustrated by ROESY cross peaks from H-15 to H-11. Compound 4 was thus characterized as 3 Z , 9 E , 5 S , 6 R , similar to reported analogues in the literature [ 36 , 37 ]. Compound 4 was thus a new C-15 isoprenoid analogue related to abscisic acid, a well-known plant hormone involved in abscission [ 37 ].…”

Section: Resultssupporting

confidence: 74%

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

et al. 2021

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The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavonoids was related to the presence of both methyl and prenyl groups. The potential origin of the methyl in the flavonoids is discussed, as well as the chemophenetic significance of our findings. Isolation was performed over repeated silica gel and Sephadex LH-20 column chromatography and the structures were elucidated by (NMR and MS). The crude methanol extract and isolated compounds showed considerable antibacterial potency against a panel of multi-drug resistant (MDR) bacterial strains. The best MIC values were obtained with compound (2) against S. aureus ATCC 25923 (32 µg/mL) and MRSA1 (16 µg/mL).

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Section: Resultssupporting

confidence: 74%

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

et al. 2021

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“…WGHL2 also showed four new meroterpenoids, namely, guignardones U–X, along with known meroterpenoids. However, none of the four newly isolated compounds showed anti-fungal activity ( Yan et al, 2021 ) ( Table1 and Figure 1 ).…”

Section: Biological Activities Of Meroterpenoidsmentioning

confidence: 99%

Biological activities of meroterpenoids isolated from different sources

et al. 2022

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Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria and multicellular organisms such as fungi, plants, and animals, including those of marine origin. Structurally, these compounds exhibit a wide diversity depending upon the origin and the biosynthetic pathway they emerge from. This diversity in structural features imparts a wide spectrum of biological activity to meroterpenoids. Based on the biosynthetic pathway of origin, these compounds are either polyketide-terpenoids or non-polyketide terpenoids. The recent surge of interest in meroterpenoids has led to a systematic screening of these compounds for many biological actions. Different meroterpenoids have been recorded for a broad range of operations, such as anti-cholinesterase, COX-2 inhibitory, anti-leishmanial, anti-diabetic, anti-oxidative, anti-inflammatory, anti-neoplastic, anti-bacterial, antimalarial, anti-viral, anti-obesity, and insecticidal activity. Meroterpenoids also possess inhibitory activity against the expression of nitric oxide, TNF- α, and other inflammatory mediators. These compounds also show renal protective, cardioprotective, and neuroprotective activities. The present review includes literature from 1999 to date and discusses 590 biologically active meroterpenoids, of which 231 are from fungal sources, 212 are from various species of plants, and 147 are from marine sources such as algae and sponges.

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γ‐Aromatic Butenolides of Microbial Source – A Review of Their Structures, Biological Activities and Biosynthesis

Fan

Wei

Si-Tu

et al. 2022

Chemistry & Biodiversity

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γ‐Aromatic butenolides (γ‐AB) are an important type of structures found in many bioactive microbial secondary metabolites (SMs). γ‐AB refer to a group of natural products (NPs) containing five‐membered (unsaturated) lactones with 3‐phenyl and 4‐benzyl substituents. Their wide‐range biological activities have inspired pharmaceutical chemists to explore its biosynthesis mechanisms and design strategies to construct the γ‐AB skeleton. Recently, there are a great deal of interesting research progress on the structures, biological activities and biosynthesis of γ‐AB. This review will focus on these aspects and summarize the important achievements of γ‐AB from 1975 to 2021.

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Antifungal meroterpenes and dioxolanone derivatives from plant-associated endophytic fungus Phyllosticta sp. WGHL2

Cited by 9 publications

References 22 publications

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

Biological activities of meroterpenoids isolated from different sources

γ‐Aromatic Butenolides of Microbial Source – A Review of Their Structures, Biological Activities and Biosynthesis

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