Antifungal, Nematicidal and Antioxidant Activity of the Methanol Extracts Obtained from Medicinal Plants

Journal of the American Mosquito Control Association

Kim²,

Lee³

2015

The objective of this study was to determine the larvicidal activity of an active compound isolated from Cercis chinensis heartwood and its structurally related analogs against 4th-stage Aedes aegypti, Culex pipiens pallens, and Ae. togoi. The larvicidal compound of C. chinensis was isolated with the use of various chromatographic techniques and identified as analogs of 1,4-naphthalenedione. Based on the median lethal concentration (LC(50)) values of commercially procured analogs against Ae. aegypti larvae, the most toxic analog was 2-bromo-1,4-naphthalenedione (1.19 µg/ml); followed by 5-hydroxy-1,4-naphthalenedione (1.72 µg/ml); 2-methyl-1,4-naphthalenedione (9.12 µg/ml); 2-hydroxy-1,4-naphthalenedione (10.76 µg/ml); and 2-methoxy-1,4-naphthalenedione (12.50 µg/ml). Similar results were observed against Cx. p. pallens and Ae. togoi larvae with 1,4-naphthalenedione analogs. These results also showed that 1,4-naphthalenedione analogs were less toxic than the organophosphate pirimiphos-methyl. Nonetheless, naturally occurring C. chinensis-derived materials and 1,4-naphthalenedione analogs have potential for development as mosquito larvicidal agents.

Section: Introductionmentioning

confidence: 99%

Larvicidal Activity of Naturally Occurring Naphthalenedione and its Structurally Related Analogs Against Three Mosquito Species

Journal of the American Mosquito Control Association

Kim²,

Lee³

2015

“…Botanical pesticides have long been used as an alternative source to synthetic chemicals for pest management because plant secondary metabolites show a broad range of insecticidal effects against agricultural, hygienic, and stored product insect pests, such as aphids, mites, mosquitoes, and weevils. ,,, Moreover, because plant-derived materials have multiple novel target points of action, the chance of developing a resistant individual is very low Citrullus colocynthis, a member of the Cucurbitaceae family, is a medicinal plant distributed throughout Asia, which has been used in material for traditional medicines for arthritis, diabetes, inflammatory disorders, and stomachache. − However, the acaricidal and insecticidal activities of the active constituent isolated from C. colocynthis fruits and its structurally related analogues against Tetranychus urticae, Sitophilus oryzae, and Sitophilus zeamais adults have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Biofunctional Constituent Isolated fromCitrullus colocynthisFruits and Structure–Activity Relationships of Its Analogues Show Acaricidal and Insecticidal Efficacy

Lee

2014

J. Agric. Food Chem.

The acaricidal and insecticidal potential of the active constituent isolated from Citrullus colocynthis fruits and its structurally related analogues was evaluated by performing leaf disk, contact toxicity, and fumigant toxicity bioassays against Tetranychus urticae, Sitophilus oryzae, and Sitophilus zeamais adults. The active constituent of C. colocynthis fruits was isolated by chromatographic techniques and was identified as 4-methylquinoline on the basis of spectroscopic analyses. To investigate the structure-activity relationships, 4-methylquinoline and its structural analogues were tested against mites and two insect pests. On the basis of the LC50 values, 7,8-benzoquinoline was the most effective against T. urticae. Quinoline, 8-hydroxyquinoline, 2-methylquinoline, 4-methylquinoline, 6-methylquinoline, 8-methylquinoline, and 7,8-benzoquinoline showed high insecticidal activities against S. oryzae and S. zeamais regardless of the application method. These results indicate that introduction of a functional group into the quinoline skeleton and changing the position of the group have an important influence on the acaricidal and insecticidal activities. Furthermore, 4-methylquinoline isolated from C. colocynthis fruits, along with its structural analogues, could be effective natural pesticides for managing spider mites and stored grain weevils.

mentioning

confidence: 99%

“…Plant essential oils and their phytochemicals show a broad range of biological activities against bacteria, fungi, and various arthropods (8,15,20,22). Moreover, because of the multiple and novel points of action through which the plant oil can act, the possibility of developing a resistant population is low (4,20). Rosemary (Rosmarinus officinalis L., Labiatae) oil has been traditionally used as a medicine for abdominal pain, nervous disorders, and menstrual pain (18).…”

mentioning

confidence: 99%

Active Monoterpene Ketones Isolated from Rosmarinus officinalis with Fumigant and Contact Action against Tyrophagus putrescentiae (Schrank)

Journal of Food Protection

Park

Chung

et al. 2014

The acaricidal activities of an active material derived from Rosmarinus officinalis oil and its relative monoterpene ketones were determined using fumigant and contact toxicity bioassays against Tyrophagus putrescentiae and were compared with that of a commercial acaricide (benzyl benzoate). The active component of R. officinalis oil, isolated by silica gel column chromatography and high-performance liquid chromatography, was identified as camphor, based on various spectroscopic analyses. In the fumigant toxicity bioassay, camphor (2.25 μg/cm(3)) was 5.58 times more active than benzyl benzoate (12.56 μg/cm(3)) against T. putrescentiae, followed by (+)-camphor (3.89 μg/cm(3)) and (-)-camphor (5.61 μg/cm(3)). In the contact toxicity bioassay, camphor (1.34 μg/cm(2)) was 6.74 times more toxic than benzyl benzoate (9.03 μg/cm(2)) against T. putrescentiae, followed by (+)-camphor (2.23 μg/cm(2)) and (-)-camphor (2.94 μg/cm(2)). These results indicate that camphor and its derivatives are very useful as potential control agents against stored food mites regardless of the application method.