Antifungal Saponins from the Maya Medicinal Plant <i>Cestrum schlechtendahlii</i> G. Don (Solanaceae)

Ta, Chieu Anh Kim; Guerrero‐Analco, José A.; Roberts, Elizabeth Lewis; Li, Rui; Mogg, Christopher; Saleem, Ammar; Otárola-Rojas, Marco; Poveda, Luis; Sánchez-Vindas, Pablo; Cal, Victor; Caal, Federico; Subramaniam, Rajagopal; Smith, Myron L.; Arnason, John T.

doi:10.1002/ptr.5545

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…For example, pennogenin steroidal saponins isolated from the ethanolic extract of P. polyphylla var. yunnanensis , exhibited moderate antifungal activity against S. cerevisiae and C. albicans [ 36 ] and the spirostanol saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl- o -α-l-rhamnopyranosyl-(1→2)-β- d -galactopyranoside present in Cestrum schlechtendahlii (at 0.5 mg/disk) inhibited the growth of S. cerevisiae , C. albicans , Cryptococcus neoformans , and F. graminearum [ 37 ]. In addition, other biological activities have been also reported for spirostan derivatives.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Identification of Pennogenin Tetraglycoside from Cestrum nocturnum (Solanaceae) and Its Antifungal Activity against Fusarium kuroshium, Causal Agent of Fusarium Dieback

et al. 2022

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Antifungal assay-guided fractionation of the methanolic crude extract of Cestrum nocturnum (Solanaceae), popular known as ‘lady of the night’, led the isolation and identification of the steroidal saponin named pennogenin tetraglycoside, which was identified for the first time in this plant species by spectroscopic means. The crude extract, fractions and pennogenin tetraglycoside exhibited mycelial growth inhibition of Fusarium solani and F. kuroshium. F. solani is a cosmopolitan fungal phytopathogen that affects several economically important crops. However, we highlight the antifungal activity displayed by pennogenin tetraglycoside against F. kuroshium, since it is the first plant natural product identified as active for this phytopathogen. This fungus along with its insect symbiont known as Kuroshio shot hole borer (Euwallacea kuroshio) are the causal agents of the plant disease Fusarium dieback that affects more than 300 plant species including avocado (Persea americana) among others of ecological relevance. Scanning electron microscopy showed morphological alterations of the fungal hyphae after exposure with the active fractions and 12 phenolic compounds were also identified by mass spectrometry dereplication as part of potential active molecules present in C. nocturnum leaves.

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Section: Discussionmentioning

confidence: 99%

Isolation and Identification of Pennogenin Tetraglycoside from Cestrum nocturnum (Solanaceae) and Its Antifungal Activity against Fusarium kuroshium, Causal Agent of Fusarium Dieback

et al. 2022

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“…The use of medicinal plants by the Q'eqchi' of Guatemala has been the subject of previous studies using different approaches, some of the most recent being studies on a specific species to treat the culture-bound illness “susto” (Mullally et al, 2016 ), the antifungal activity of a single species (Ta et al, 2016 ), the diagnosis of the single culture-bound illness “emplotment” (Hatala and Waldram, 2017 ), the investigation and review of Q'eqchi women's reproductive health in the Lake Izabal region (Michel et al, 2016 ), the broad study of Mayan phytomedicine in Guatemala and a further proposal for patient-centered boundary mechanisms to foster intercultural partnerships in health care (Hitziger et al, 2016 , 2017 ). The present study differs from these previous studies because it was conducted in three communities of Alta Verapaz with a normal population (no traditional healers).…”

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

Vargas

Andrade‐Cetto

2018

Front. Pharmacol.

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Mesoamerica is well known for the Mayan civilization, which flourished in this region during pre-Columbian times and made use of plant diversity for medicinal purposes. Currently, there are 21 Mayan ethnic groups in Guatemala, including the Q'eqchi'. The use of medicinal plants is still prevalent among them, they have been an important medicinal source for the population. The present study aims to compile traditional knowledge of the use of medicinal plants from three Q'eqchi' communities in Alta Verapaz, Guatemala and identify the important medicinal plants that are currently being used to treat relevant diseases. The study also aims to determine the relative importance of the identified species to propose new species for further pharmacological studies. Based on the cultural richness and the low level of perturbation of the vegetation, we selected the Q'eqchi' communities of Sanimtaqá, Santo Domingo de las Cuevas, and Chirrepec in Alta Verapaz, Guatemala. There, semi-structured interviews were conducted between June 2013 and December 2014 with common people. Plant-related questions and certain sociocultural contexts of the informants were included. Herbarium specimens for identification were collected with the help of the informants in their gardens with people from each community. The data were analyzed in two forms, the first non-quantitative based on the interpretation of the interviews (emic concepts of diseases) the second by following quantitative methods: informant consensus factor (Fic), Friedman's fidelity index (Fl), and use-reports (Ur). A total of 169 interviews were conducted. One hundred thirty-seven species of plants with medicinal uses were identified, which were described 2,055 times. These species belong to 59 families and 117 genera. Gastrointestinal conditions and pain/fever had the highest number of plant species uses for treatment. The main gastrointestinal conditions included diarrhea (Nume'sa'), stomach pain and worms (Luqum), while the pain/fever classification included headaches (rail jolom), and fevers (Tiq'). The most important cultural condition is called Chaquiq'yaj, the symptoms of the disease; diarrhea, vomiting, fever, lack of appetite, and thirst could be associated with a gastrointestinal. Conclusions: After analyzing the data, we can conclude that; Ageratina ligustrina, Catopheria chiapensis, Baccharis inamoena, Peperomia maculosa, Baccharis salicina, Clinopodium brownei, Calea integrifolia, and Smallanthus maculatus var. maculatus are the most culturally relevant species.

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“…The best antifungal activity was found in Cestrum schlechtendalii G.Don (Ik che in Q'eqchi'), used for athlete's foot. Two spirostanol saponins were isolated via bioassay-guided isolation (Ta et al 2016). The major saponin (Fig.…”

Section: Healing and Mental Healthmentioning

confidence: 99%

A review of ethnobotany and ethnopharmacology of traditional medicines used by Q’eqchi’ Maya Healers of Xna’ajeb’ aj Ralch’o’och’, Belize

Arnason

Cal²,

Pesek

et al. 2022

Botany

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This review describes an Indigenous led project by Q’eqchi’ Maya healers of Belize to strengthen and improve traditional botanical healing. Goals of the project were to conserve medicinal plant knowledge, leading to ethnobotanical studies, and to conserve the plants themselves, by creating a community ethnobotanical garden. A total of 169 medicinal species were collected in the ethnobotanical survey, which provided unique knowledge on many rainforest species of the wet lowland forest of Southern Belize, not found in neighbouring Indigenous cultures. Consensus on plant uses by the healers was high indicating a well conserved codified oral history. After horticultural experimentation by the healers, the Indigenous botanical garden provided a habitat for and conservation of 102 medicinal species including many epiphytes that were rescued from forested areas. Ethnopharmacological studies by the university partners showed a pharmacological basis for, and active principles of plants used for epilepsy and anxiety, for inflammatory conditions such as arthritis, for dermatological mycoses, and for type 2 diabetes complications. Overall, the project has provided a model for Indigenous empowerment and First Nation’s science, as well as establishing this traditional medicine as an important, unified healing practice, that can safely and effectively provide primary healthcare in its cultural context.

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Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae)

Cited by 13 publications

References 28 publications

Isolation and Identification of Pennogenin Tetraglycoside from Cestrum nocturnum (Solanaceae) and Its Antifungal Activity against Fusarium kuroshium, Causal Agent of Fusarium Dieback

Isolation and Identification of Pennogenin Tetraglycoside from Cestrum nocturnum (Solanaceae) and Its Antifungal Activity against Fusarium kuroshium, Causal Agent of Fusarium Dieback

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala

A review of ethnobotany and ethnopharmacology of traditional medicines used by Q’eqchi’ Maya Healers of Xna’ajeb’ aj Ralch’o’och’, Belize

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