Antifungal Sesquiterpenoids from Michelia formosana Leaf Essential Oil against Wood-Rotting Fungi

Abstract

Michelia formosana (Kanehira) Masamune is a broad-leaved species widespread in East Asia; the wood extract and its constituents possess antifungal activity against wood-decay fungi. Antifungal activities of leaf essential oil and its constituents from M. formosana were investigated in the present study. Bioassay-guided isolation was applied to isolate the phytochemicals from leaf essential oil. 1D and 2D NMR, FTIR, and MS spectroscopic analyses were applied to elucidate the chemical structures of isolated compounds. Leaf essential oil displayed antifungal activity against wood decay fungi and was further separated into 11 fractions by column chromatography. Four sesquiterpenoids were isolated and identified from the active fractions of leaf essential oil through bioassay-guided isolation. Among these sesquiterpenoids, guaiol, bulnesol, and β-elemol have higher antifungal activity against brown-rot fungus Laetiporus sulphureus and white-rot fungus Lenzites betulina. Leaf essential oil and active compounds showed better antifungal activity against L. sulphureus than against L. betulina. The molecular structure of active sesquiterpenoids all contain the hydroxyisopropyl group. Antifungal sesquiterpenoids from M. formosana leaf essential oil show potential as natural fungicides for decay control of lignocellulosic materials.

Xanthine Oxidase Inhibitory Activity and Chemical Composition of Pistacia chinensis Leaf Essential Oil

“…P. chinensis leaf essential oil (50 g) was further subjected to classical preparative silica gel column chromatography (CC) with a gradient elution of n -hexane and ethyl acetate of increasing polarity, and then separated into six fractions (E1–E6) using thin-layer chromatography (TLC) to analyze the elution profiles at both 254 nm and 365 nm UV light [ 41 , 42 , 43 ].…”

Simultaneous Hydrodistillation of Cedrus atlantica Manetti and Salvia rosmarinus Spenn: Optimization of anti-wood-decay fungal activity using mixture design methodology

“…Rhafouri et al (2014) found that both wooddecay fungi, G. trabeum and P. placenta, were stopped growth at a concentration of 1/250 v/v Atlas cedar seed essential oil. Another study indicated that the antifungal effect of sesquiterpenes against the brown-decay fungus L. sulphureus was high compared to that of the white-decay fungus L. betulina (Wu et al 2022). In addition, Ljunggren et al (2020) found that himachalene showed effective antifungal activity against C. puteana.…”

“…Wood extracts constitute an important class of secondary metabolites (Schultz and Nicholas 2002). Several wood species seem indebted contain chemical compounds (Bhardwaj et al 2012;Wu et al 2022). These compounds make trees resistant to insect attacks (Soidrou et al 2013).…”

Penyelidikan Aktivitas Antikanker Payudara oleh Minyak Atsiri Bunga Michelia Alba Secara In Silico

“…Selain kayu, M. alba juga menghasilkan minyak atsiri bernilai tinggi yang digunakan sebagai topnote kunci pada parfum berharga mahal seperti Joy dan J'adore [7,8]. Beberapa spesies Michelia telah digunakan sebagai obat tradisional untuk berbagai penyakit seperti bronkitis, prostatitis, dan kanker [9][10][11]. M. alba diketahui menunjukkan aktivitas antijamur [12], antibakteri [13], dan telah digunakan dalam pengobatan demam, sifilis, gonorrhoea, malaria, dan aborsi [14].…”